ID A0A087WZW3_HUMAN Unreviewed; 1789 AA. AC A0A087WZW3; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 05-DEC-2018, entry version 37. DE SubName: Full=Protocadherin-15 {ECO:0000313|Ensembl:ENSP00000482921}; GN Name=PCDH15 {ECO:0000313|Ensembl:ENSP00000482921}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482921, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000482921, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., RA Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000482921} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC013737; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC016817; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC024073; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC027671; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL353784; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL360214; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL365496; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL391356; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF455239; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A087WZW3; -. DR EPD; A0A087WZW3; -. DR Ensembl; ENST00000612394; ENSP00000482921; ENSG00000150275. DR UCSC; uc057tik.1; human. DR EuPathDB; HostDB:ENSG00000150275.17; -. DR HGNC; HGNC:14674; PCDH15. DR OpenTargets; ENSG00000150275; -. DR eggNOG; KOG3594; Eukaryota. DR eggNOG; ENOG410XQHI; LUCA. DR GeneTree; ENSGT00940000156675; -. DR ChiTaRS; PCDH15; human. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000150275; Expressed in 67 organ(s), highest expression level in corpus callosum. DR ExpressionAtlas; A0A087WZW3; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:InterPro. DR GO; GO:0032420; C:stereocilium; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro. DR GO; GO:0048839; P:inner ear development; IEA:InterPro. DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro. DR InterPro; IPR002126; Cadherin-like_dom. DR InterPro; IPR015919; Cadherin-like_sf. DR InterPro; IPR020894; Cadherin_CS. DR InterPro; IPR030718; Protocadherin-15. DR PANTHER; PTHR24028:SF11; PTHR24028:SF11; 4. DR Pfam; PF00028; Cadherin; 8. DR PRINTS; PR00205; CADHERIN. DR SMART; SM00112; CA; 11. DR SUPFAM; SSF49313; SSF49313; 10. DR PROSITE; PS00232; CADHERIN_1; 3. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|SAAS:SAAS00020193}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A087WZW3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00436611}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00616217, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00616217, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 1789 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001832127. FT TRANSMEM 1387 1409 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 69 150 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 179 268 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 309 398 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 431 519 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 543 625 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 650 727 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 751 829 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 853 936 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 960 1046 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 1067 1154 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 1178 1262 CA. {ECO:0000259|SMART:SM00112}. FT COILED 1487 1507 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 1789 AA; 198685 MW; 1745066024D281C0 CRC64; MFRQFYLWTC LASGIILGSL FEICLGQYDD DWQYEDCKLA RGGPPATIVA IDEESRNGTI LVDNMLIKGT AGGPDPTIEL SLKDNVDYWV LMDPVKQMLF LNSTGRVLDR DPPMNIHSIV VQVQCINKKV GTIIYHEVRI VVRDRNDNSP TFKHESYYAT VNELTPVGTT IFTGFSGDNG ATDIDDGPNG QIEYVIQYNP DDPTSNDTFE IPLMLTGNIV LRKRLNYEDK TRYFVIIQAN DRAQNLNERR TTTTTLTVDV LDGDDLGPMF LPCVLVPNTR DCRPLTYQAA IPELRTPEEL NPIIVTPPIQ AIDQDRNIQP PSDRPGILYS ILVGTPEDYP RFFHMHPRTA ELSLLEPVNR DFHQKFDLVI KAEQDNGHPL PAFAGLHIEI LDENNQSPYF TMPSYQGYIL ESAPVGATIS DSLNLTSPLR IVALDKDIED VPPSGVPTKD PELHLFLNDY TSVFTVTQTG ITRYLTLLQP VDREEQQTYT FSITAFDGVQ ESEPVIVNIQ VMDANDNTPT FPEISYDVYV YTDMRPGDSV IQLTAVDADE GSNGEITYEI LVGAQGDFII NKTTGLITIA PGVEMIVGRT YALTVQAADN APPAERRNSI CTVYIEVLPP NNQSPPRFPQ LMYSLEISEA MRVGAVLLNL QATDREGDSI TYAIENGDPQ RVFNLSETTG ILTLGKALDR ESTDRYILII TASDGRPDGT STATVNIVVT DVNDNAPVFD PYLPRNLSVV EEEANAFVGQ VKATDPDAGI NGQVHYSLGN FNNLFRITSN GSIYTAVKLN REVRDYYELV VVATDGAVHP RHSTLTLAIK VLDIDDNSPV FTNSTYTVLV EENLPAGTTI LQIEAKDVDL GANVSYRIRS PEVKHFFALH PFTGELSLLR SLDYEAFPDQ EASITFLVEA FDIYGTMPPG IATVTVIVKD MNDYPPVFSK RIYKGMVAPD AVKGTPITTV YAEDADPPGL PASRVRYRVD DVQFPYPASI FEVEEDSGRV ITRVNLNEEP TTIFKLVVVA FDDGEPVMSS SATVKILVLH PGEIPRFTQE EYRPPPVSEL ATKGTMVGVI SAAAINQSIV YSIVSGNEED TFGINNITGV IYVNGPLDYE TRTSYVLRVQ ADSLEVVLAN LRVPSKSNTA KVYIEIQDEN NHPPVFQKKF YIGGVSEDAR MFTSVLRVKA TDKDTGNYSV MAYRLIIPPI KEGKEGFVVE TYTGLIKTAM LFHNMRRSYF KFQVIATDDY GKGLSGKADV LVSVVNQLDM QVIVSNVPPT LVEKKIEDLT EILDRYVQEQ IPGAKVVVES IGARRHGDAF SLEDYTKCDL TVYAIDPQTN RAIDRNELFK FLDGKLLDIN KDFQPYYGEG GRILEIRTPE AVTSIKKRGE SLGYTEGALL ALAFIIILCC IPAILVVLVS YRQVFKGRQA ECTKTARIQA ALPAAKPAVP APAPVAAPPP PPPPPPGAHL YEELGDSSMY EMPQYGSRRR LLPPAGQEEY GEVVGEAEEE YEEEEEEPKK IKKPKVEIRE PSEEEEVVVT IEKPPAAEPT YTTWKRARIF PMIFKKVRGL ADKRGIVDLE GEEWQRRLEE EDKDYLKLTL DQEEATESTV ESEEESSSDY TEYSEEESEF SESETTEEES ESETPSEEEE SSTPESEESE STESEGEKAR KNIVLARRRP MVEEVKEVKG RKEEPQEEQK EPKMEEEEHS EEEESGPAPV EESTDPEAQD IPEEGSAESA SVEGGVESEE ESESGSSSSS SESQSGGPWG YQVPAYDRSK NANQKKSPGA NSEGYNTAL //