ID   A0A087WZU1_HUMAN        Unreviewed;      2299 AA.
AC   A0A087WZU1;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   13-FEB-2019, entry version 41.
DE   SubName: Full=Phosphatidylinositol phosphatase PTPRQ {ECO:0000313|Ensembl:ENSP00000482885};
GN   Name=PTPRQ {ECO:0000313|Ensembl:ENSP00000482885};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482885, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000482885, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RG   Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A., null.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000482885}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000495607}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein]
CC         + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|SAAS:SAAS01128831};
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; ABBA01053496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC074031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC083812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001138498.1; NM_001145026.1.
DR   UniGene; Hs.539284; -.
DR   ProteinModelPortal; A0A087WZU1; -.
DR   IntAct; A0A087WZU1; 8.
DR   PeptideAtlas; A0A087WZU1; -.
DR   Ensembl; ENST00000614701; ENSP00000482885; ENSG00000139304.
DR   Ensembl; ENST00000644991; ENSP00000495607; ENSG00000139304.
DR   GeneID; 374462; -.
DR   KEGG; hsa:374462; -.
DR   UCSC; uc031zgj.2; human.
DR   CTD; 374462; -.
DR   EuPathDB; HostDB:ENSG00000139304.12; -.
DR   HGNC; HGNC:9679; PTPRQ.
DR   OpenTargets; ENSG00000139304; -.
DR   GeneTree; ENSGT00940000159215; -.
DR   KO; K16910; -.
DR   OrthoDB; 411281at2759; -.
DR   ChiTaRS; PTPRQ; human.
DR   GenomeRNAi; 374462; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000139304; Expressed in 77 organ(s), highest expression level in kidney.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032421; C:stereocilium bundle; IEA:Ensembl.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IEA:Ensembl.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR   GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
DR   GO; GO:0060116; P:vestibular receptor cell morphogenesis; IEA:Ensembl.
DR   CDD; cd00063; FN3; 15.
DR   Gene3D; 2.60.40.10; -; 14.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTPase_domain.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; TYR_PHOSPHATASE_dom.
DR   Pfam; PF00041; fn3; 12.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00060; FN3; 16.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF49265; SSF49265; 8.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS50853; FN3; 17.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01031415};
KW   Membrane {ECO:0000256|SAAS:SAAS00897767, ECO:0000256|SAM:Phobius};
KW   Protein phosphatase {ECO:0000256|SAAS:SAAS01031415};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18   2299       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832099.
FT   TRANSMEM   1906   1928       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1     57       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN       58    153       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      157    252       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      308    396       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      399    497       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      568    663       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      668    757       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      762    852       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      857    946       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      951   1051       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1056   1148       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1150   1240       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1245   1338       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1342   1428       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1432   1536       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1541   1639       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1644   1745       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     2003   2259       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   DOMAIN     2179   2250       TYR_PHOSPHATASE_2.
FT                                {ECO:0000259|PROSITE:PS50056}.
FT   ACT_SITE   2200   2200       Phosphocysteine intermediate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00160}.
SQ   SEQUENCE   2299 AA;  257263 MW;  8F4F19B947ED83F9 CRC64;
     MDFLIIFLLL FIGTSETQVD VSNVVPGTRY DITISSISTT YTSPVTRIVT TNVTKPGPPV
     FLAGERVGSA GILLSWNTPP NPNGRIISYI VKYKEVCPWM QTVYTQVRSK PDSLEVLLTN
     LNPGTTYEIK VAAENSAGIG VFSDPFLFQT AESAPGKVVN LTVEAYNASA VKLIWYLPRQ
     PNGKITSFKI SVKHARSGIV VKDVSIRVED ILTGKLPECN ENSESFLWST ASPSPTLGRV
     TPPSRTTHSS STLTQNEISS VWKEPISFVV THLRPYTTYL FEVSAATTEA GYIDSTIVRT
     PESVPEGPPQ NCVTGNITGK SFSILWDPPT IVTGKFSYRV ELYGPSGRIL DNSTKDLKFA
     FTNLTPFTMY DVYIAAETSA GTGPKSNISV FTPPDVPGAV FDLQLAEVES TQVRITWKKP
     RQPNGIINQY RVKVLVPETG IILENTLLTG NNEYINDPMA PEIVNIVEPM VGLYEGSAEM
     SSDLHSLATF IYNSHPDKNF PARNRAEDQT SPVVTTRNQY ITDIAAEQLS YVIRRLVPFT
     EHMISVSAFT IMGEGPPTVL SVRTRQQVPS SIKIINYKNI SSSSILLYWD PPEYPNGKIT
     HYTIYAMELD TNRAFQITTI DNSFLITGLK KYTKYKMRVA ASTHVGESSL SEENDIFVRT
     SEDEPESSPQ DVEVIDVTAD EIRLKWSPPE KPNGIIIAYE VLYKNIDTLY MKNTSTTDII
     LRNLRPHTLY NISVRSYTRF GHGNQVSSLL SVRTSETVPD SAPENITYKN ISSGEIELSF
     LPPSSPNGII QKYTIYLKRS NGNEERTINT TSLTQNIKVL KKYTQYIIEV SASTLKGEGV
     RSAPISILTE EDAPDSPPQD FSVKQLSGVT VKLSWQPPLE PNGIILYYTV YVWNRSSLKT
     INVTETSLEL SDLDYNVEYS AYVTASTRFG DGKTRSNIIS FQTPEGAPSD PPKDVYYANL
     SSSSIILFWT PPSKPNGIIQ YYSVYYRNTS GTFMQNFTLH EVTNDFDNMT VSTIIDKLTI
     FSYYTFWLTA STSVGNGNKS SDIIEVYTDQ DIPEGFVGNL TYESISSTAI NVSWVPPAQP
     NGLVFYYVSL ILQQTPRHVR PPLVTYERSI YFDNLEKYTD YILKITPSTE KGFSDTYTAQ
     LYIKTEEDVP ETSPIINTFK NLSSTSVLLS WDPPVKPNGA IISYDLTLQG PNENYSFITS
     DNYIILEELS PFTLYSFFAA ARTRKGLGPS SILFFYTDES VPLAPPQNLT LINCTSDFVW
     LKWSPSPLPG GIVKVYSFKI HEHETDTIYY KNISGFKTEA KLVGLEPVST YSIRVSAFTK
     VGNGNQFSNV VKFTTQESVP DVVQNMQCMA TSWQSVLVKW DPPKKANGII TQYMVTVERN
     STKVSPQDHM YTFIKLLANT SYVFKVRAST SAGEGDESTC HVSTLPETVP SVPTNIAFSD
     VQSTSATLTW IRPDTILGYF QNYKITTQLR AQKCKEWESE ECVEYQKIQY LYEAHLTEET
     VYGLKKFRWY RFQVAASTNA GYGNASNWIS TKTLPGPPDG PPENVHVVAT SPFSISISWS
     EPAVITGPTC YLIDVKSVDN DEFNISFIKS NEENKTIEIK DLEIFTRYSV VITAFTGNIS
     AAYVEGKSSA EMIVTTLESA PKDPPNNMTF QKIPDEVTKF QLTFLPPSQP NGNIQVYQAL
     VYREDDPTAV QIHNLSIIQK TNTFVIAMLE GLKGGHTYNI SVYAVNSAGA GPKVPMRITM
     DIKAPARPKT KPTPIYDATG KLLVTSTTIT IRMPICYYSD DHGPIKNVQV LVTETGAQHD
     GNVTKWYDAY FNKARPYFTN EGFPNPPCTE GKTKFSGNEE IYIIGADNAC MIPGNEDKIC
     NGPLKPKKQY LFKFRATNIM GQFTDSDYSD PVKTLGEGLS ERTVEIILSV TLCILSIILL
     GTAIFAFARI RQKQKEGGTY SPQDAEIIDT KLKLDQLITV ADLELKDERL TRLLSYRKSI
     KPISKKSFLQ HVEELCTNNN LKFQEEFSEL PKFLQDLSST DADLPWNRAK NRFPNIKPYN
     NNRVKLIADA SVPGSDYINA SYISGYLCPN EFIATQGPLP GTVGDFWRMV WETRAKTLVM
     LTQCFEKGRI RCHQYWPEDN KPVTVFGDIV ITKLMEDVQI DWTIRDLKIE RHGDCMTVRQ
     CNFTAWPEHG VPENSAPLIH FVKLVRASRA HDTTPMIVHC SAGVGRTGVF IALDHLTQHI
     NDHDFVDIYG LVAELRSERM CMVQNLAQYI FLHQCILDLL SNKGSNQPIC FVNYSALQKM
     DSLDAMEGDV ELEWEETTM
//