ID A0A087WZQ8_HUMAN Unreviewed; 574 AA. AC A0A087WZQ8; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 16-JAN-2019, entry version 30. DE SubName: Full=Macrophage-stimulating protein receptor {ECO:0000313|Ensembl:ENSP00000482827}; GN Name=MST1R {ECO:0000313|Ensembl:ENSP00000482827}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482827, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000482827, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., RA Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., RA Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., RA Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000482827} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC105935; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC876868; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A087WZQ8; -. DR jPOST; A0A087WZQ8; -. DR PeptideAtlas; A0A087WZQ8; -. DR Ensembl; ENST00000613534; ENSP00000482827; ENSG00000164078. DR UCSC; uc062jyv.1; human. DR EuPathDB; HostDB:ENSG00000164078.12; -. DR HGNC; HGNC:7381; MST1R. DR OpenTargets; ENSG00000164078; -. DR eggNOG; KOG1095; Eukaryota. DR eggNOG; KOG3610; Eukaryota. DR eggNOG; ENOG410XRIK; LUCA. DR GeneTree; ENSGT00940000157842; -. DR ChiTaRS; MST1R; human. DR Proteomes; UP000005640; Chromosome 3. DR Bgee; ENSG00000164078; Expressed in 125 organ(s), highest expression level in mucosa of transverse colon. DR ExpressionAtlas; A0A087WZQ8; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. DR Gene3D; 2.130.10.10; -; 1. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR001627; Semap_dom. DR InterPro; IPR036352; Semap_dom_sf. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR Pfam; PF07714; Pkinase_Tyr; 1. DR Pfam; PF01403; Sema; 1. DR SMART; SM00630; Sema; 1. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF101912; SSF101912; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:A0A087WZQ8, KW ECO:0000213|PeptideAtlas:A0A087WZQ8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 574 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001832138. FT TRANSMEM 232 257 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 357 574 Protein kinase. FT {ECO:0000259|PROSITE:PS50011}. SQ SEQUENCE 574 AA; 62255 MW; E985B3E9A1D0B244 CRC64; MELLPPLPQS FLLLLLLPAK PAAGEDWQCP RTPYAASRDF DVKYVVPSFS AGGLVQAMVT YEGDRNESAV FVAIRNRLHV LGPDLKSVQS LATGPAGDPG CQTCAACGPG PHGPPGDTDT KVLVLDPALP ALVSCGSSLQ GRCFLHDLEP QGTAVHLAAP ACLFSAHHNR PDDCPDCVAS PLGTRVTVVE QGQASYFYVA SSLDAAVAAS FSPRSVSIRR LKADASGFAP GFVALSVLPL LLLVAALATA LVFSYWWRRK QLVLPPNLND LASLDQTAGA TPLPILYSGS DYRSGLALPA IDGLDSTTCV HGASFSDSED ESCVPLLRKE SIQLRDLDSA LLAEVKDVLI PHERVVTHSD RVIGKGHFGV VYHGEYIDQA QNRIQCAIKS LSRITEMQQV EAFLREGLLM RGLNHPNVLA LIGIMLPPEG LPHVLLPYMC HGDLLQFIRS PQRNPTVKDL ISFGLQVARG MEYLAEQKFV HRDLAARNCM YQVMQQCWEA DPAVRPTFRV LVGEVEQIVS ALLGDHYVQL PATYMNLGPS TSHEMNVRPE QPQFSPMPGN VRRPRPLSEP PRPT //