ID   A0A087WZP6_HUMAN        Unreviewed;       969 AA.
AC   A0A087WZP6;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   13-FEB-2019, entry version 39.
DE   SubName: Full=Nidogen-2 {ECO:0000313|Ensembl:ENSP00000482803};
GN   Name=NID2 {ECO:0000313|Ensembl:ENSP00000482803};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482803, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000482803, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [3] {ECO:0000313|Ensembl:ENSP00000482803}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AL118557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL358333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WZP6; -.
DR   jPOST; A0A087WZP6; -.
DR   PeptideAtlas; A0A087WZP6; -.
DR   Ensembl; ENST00000617139; ENSP00000482803; ENSG00000087303.
DR   UCSC; uc059bnj.1; human.
DR   EuPathDB; HostDB:ENSG00000087303.16; -.
DR   HGNC; HGNC:13389; NID2.
DR   OpenTargets; ENSG00000087303; -.
DR   eggNOG; ENOG410IMYX; Eukaryota.
DR   eggNOG; ENOG4111DVZ; LUCA.
DR   GeneTree; ENSGT00940000157901; -.
DR   ChiTaRS; NID2; human.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000087303; Expressed in 189 organ(s), highest expression level in pigmented layer of retina.
DR   ExpressionAtlas; A0A087WZP6; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00255; nidG2; 1.
DR   CDD; cd00191; TY; 2.
DR   Gene3D; 2.120.10.30; -; 1.
DR   Gene3D; 4.10.800.10; -; 2.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024731; EGF_dom.
DR   InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR   InterPro; IPR009017; GFP.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   InterPro; IPR000716; Thyroglobulin_1.
DR   InterPro; IPR036857; Thyroglobulin_1_sf.
DR   Pfam; PF12662; cEGF; 1.
DR   Pfam; PF12947; EGF_3; 1.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF07474; G2F; 1.
DR   Pfam; PF00058; Ldl_recept_b; 2.
DR   Pfam; PF00086; Thyroglobulin_1; 2.
DR   SMART; SM00181; EGF; 4.
DR   SMART; SM00179; EGF_CA; 4.
DR   SMART; SM00682; G2F; 1.
DR   SMART; SM00135; LY; 5.
DR   SMART; SM00211; TY; 2.
DR   SUPFAM; SSF54511; SSF54511; 1.
DR   SUPFAM; SSF57610; SSF57610; 2.
DR   PROSITE; PS00010; ASX_HYDROXYL; 2.
DR   PROSITE; PS01186; EGF_2; 3.
DR   PROSITE; PS50026; EGF_3; 4.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS51120; LDLRB; 4.
DR   PROSITE; PS50993; NIDOGEN_G2; 1.
DR   PROSITE; PS00484; THYROGLOBULIN_1_1; 2.
DR   PROSITE; PS51162; THYROGLOBULIN_1_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00500,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677};
KW   Proteomics identification {ECO:0000213|EPD:A0A087WZP6,
KW   ECO:0000213|MaxQB:A0A087WZP6, ECO:0000213|PeptideAtlas:A0A087WZP6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00537207};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31    969       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832135.
FT   DOMAIN      122    352       Nidogen G2 beta-barrel.
FT                                {ECO:0000259|PROSITE:PS50993}.
FT   DOMAIN      353    394       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      395    437       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      442    485       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      486    522       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      531    599       Thyroglobulin type-1.
FT                                {ECO:0000259|PROSITE:PS51162}.
FT   DOMAIN      610    678       Thyroglobulin type-1.
FT                                {ECO:0000259|PROSITE:PS51162}.
FT   REPEAT      748    791       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      792    834       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      835    879       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      880    921       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   DISULFID    568    575       {ECO:0000256|PROSITE-ProRule:PRU00500}.
FT   DISULFID    648    655       {ECO:0000256|PROSITE-ProRule:PRU00500}.
SQ   SEQUENCE   969 AA;  107043 MW;  E4D156163658152F CRC64;
     MEGDRVAGRP VLSSLPVLLL LPLLMLRAAA LHPDELFPHG ESWGDQLLQE GDDESSAVVK
     LANPLHFYEA RFSNLYVGTN GIISTQDFPR ETQYVDYDFP TDFPAIAPFL ADIDTSHGRG
     RVLYRVNGKV SGHLHVGHTP VHFTDVDLHA YIVGNDGRAY TAISHIPQPA AQALLPLTPI
     GGLFGWLFAL EKPGSENGFS LAGAAFTHDM EVTFYPGEET VRITQTAEGL DPENYLSIKT
     NIQGQVPYVS ANFTAHISPY KELYHYSDST VTSTSSRDYS LTFGAINQTW SYRIHQNITY
     QVCRHAPRHP SFPTTQQLNV DRVFALYNDE ERVLRFAVTN QIGPVKEDSD PTPGNPCYDG
     SHMCDTTARC HPGTGVDYTC ECASGYQGDG RNCVDENECA TGFHRCGPNS VCINLPGSYR
     CECRSGYEFA DDRHTCILIT PPANPCEDGS HTCAPAGQAR CVHHGGSTFS CACLPGYAGD
     GHQCTDVDEC SENRCHPAAT CYNTPGSFSC RCQPGYYGDG FQCIPDSTSS LTPCEQQQRH
     AQAQYAYPGA RFHIPQCDEQ GNFLPLQCHG STGFCWCVDP DGHEVPGTQT PPGSTPPHCG
     PSPEPTQRPP TICERWRENL LEHYGGTPRD DQYVPQCDDL GHFIPLQCHG KSDFCWCVDK
     DGREVQGTRS QPGTTPACIP TVAPPMVRPT PRPDVTPPSV GTFLLYTQGQ QIGYLPLNGT
     RLQKDAAKTL LSLHGSIIVG IDYDCRERMV YWTDVAGRTI SRAGLELGAE PETIVNSGLI
     SPEGLAIDHI RRTMYWTDSV LDKIESALLD GSERKVLFYT DLVNPRAIAV DPIRGNLYWT
     DWNREAPKIE TSSLDGENRR ILINTDIGLP NGLTFDPFSK LLCWADAGTK KLECTLPDGT
     GRRVIQNNLK YPFSIVSYAD HFYHTDWRRD GVVSVNKHSG QFTDEYLPEQ RSHLYGITAV
     YPYCPTGRK
//