ID   A0A087WZN9_HUMAN        Unreviewed;      1790 AA.
AC   A0A087WZN9;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 40.
DE   SubName: Full=Protocadherin-15 {ECO:0000313|Ensembl:ENSP00000482794};
GN   Name=PCDH15 {ECO:0000313|Ensembl:ENSP00000482794};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482794, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000482794, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000482794}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC013737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC024073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC027671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL360214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL365496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL391356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001136241.1; NM_001142769.1.
DR   UniGene; Hs.280209; -.
DR   ProteinModelPortal; A0A087WZN9; -.
DR   SMR; A0A087WZN9; -.
DR   iPTMnet; A0A087WZN9; -.
DR   MaxQB; A0A087WZN9; -.
DR   PRIDE; A0A087WZN9; -.
DR   Ensembl; ENST00000613657; ENSP00000482794; ENSG00000150275.
DR   GeneID; 65217; -.
DR   UCSC; uc057tih.1; human.
DR   CTD; 65217; -.
DR   EuPathDB; HostDB:ENSG00000150275.17; -.
DR   HGNC; HGNC:14674; PCDH15.
DR   OpenTargets; ENSG00000150275; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   eggNOG; ENOG410XQHI; LUCA.
DR   GeneTree; ENSGT00940000156675; -.
DR   OrthoDB; 21247at2759; -.
DR   ChiTaRS; PCDH15; human.
DR   GenomeRNAi; 65217; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000150275; Expressed in 67 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; A0A087WZN9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0032420; C:stereocilium; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0048839; P:inner ear development; IEA:InterPro.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR030718; Protocadherin-15.
DR   PANTHER; PTHR24028:SF11; PTHR24028:SF11; 4.
DR   Pfam; PF00028; Cadherin; 8.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 11.
DR   SUPFAM; SSF49313; SSF49313; 10.
DR   PROSITE; PS00232; CADHERIN_1; 3.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087WZN9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27   1790       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832093.
FT   TRANSMEM   1387   1409       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       69    150       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      179    268       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      309    398       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      431    519       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      543    625       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      650    727       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      751    829       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      853    936       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      960   1046       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1067   1154       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1178   1262       CA. {ECO:0000259|SMART:SM00112}.
FT   COILED     1488   1508       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1790 AA;  198893 MW;  D194F8A97638D91B CRC64;
     MFRQFYLWTC LASGIILGSL FEICLGQYDD DWQYEDCKLA RGGPPATIVA IDEESRNGTI
     LVDNMLIKGT AGGPDPTIEL SLKDNVDYWV LMDPVKQMLF LNSTGRVLDR DPPMNIHSIV
     VQVQCINKKV GTIIYHEVRI VVRDRNDNSP TFKHESYYAT VNELTPVGTT IFTGFSGDNG
     ATDIDDGPNG QIEYVIQYNP DDPTSNDTFE IPLMLTGNIV LRKRLNYEDK TRYFVIIQAN
     DRAQNLNERR TTTTTLTVDV LDGDDLGPMF LPCVLVPNTR DCRPLTYQAA IPELRTPEEL
     NPIIVTPPIQ AIDQDRNIQP PSDRPGILYS ILVGTPEDYP RFFHMHPRTA ELSLLEPVNR
     DFHQKFDLVI KAEQDNGHPL PAFAGLHIEI LDENNQSPYF TMPSYQGYIL ESAPVGATIS
     DSLNLTSPLR IVALDKDIED VPPSGVPTKD PELHLFLNDY TSVFTVTQTG ITRYLTLLQP
     VDREEQQTYT FSITAFDGVQ ESEPVIVNIQ VMDANDNTPT FPEISYDVYV YTDMRPGDSV
     IQLTAVDADE GSNGEITYEI LVGAQGDFII NKTTGLITIA PGVEMIVGRT YALTVQAADN
     APPAERRNSI CTVYIEVLPP NNQSPPRFPQ LMYSLEISEA MRVGAVLLNL QATDREGDSI
     TYAIENGDPQ RVFNLSETTG ILTLGKALDR ESTDRYILII TASDGRPDGT STATVNIVVT
     DVNDNAPVFD PYLPRNLSVV EEEANAFVGQ VKATDPDAGI NGQVHYSLGN FNNLFRITSN
     GSIYTAVKLN REVRDYYELV VVATDGAVHP RHSTLTLAIK VLDIDDNSPV FTNSTYTVLV
     EENLPAGTTI LQIEAKDVDL GANVSYRIRS PEVKHFFALH PFTGELSLLR SLDYEAFPDQ
     EASITFLVEA FDIYGTMPPG IATVTVIVKD MNDYPPVFSK RIYKGMVAPD AVKGTPITTV
     YAEDADPPGL PASRVRYRVD DVQFPYPASI FEVEEDSGRV ITRVNLNEEP TTIFKLVVVA
     FDDGEPVMSS SATVKILVLH PGEIPRFTQE EYRPPPVSEL ATKGTMVGVI SAAAINQSIV
     YSIVSGNEED TFGINNITGV IYVNGPLDYE TRTSYVLRVQ ADSLEVVLAN LRVPSKSNTA
     KVYIEIQDEN NHPPVFQKKF YIGGVSEDAR MFTSVLRVKA TDKDTGNYSV MAYRLIIPPI
     KEGKEGFVVE TYTGLIKTAM LFHNMRRSYF KFQVIATDDY GKGLSGKADV LVSVVNQLDM
     QVIVSNVPPT LVEKKIEDLT EILDRYVQEQ IPGAKVVVES IGARRHGDAF SLEDYTKCDL
     TVYAIDPQTN RAIDRNELFK FLDGKLLDIN KDFQPYYGEG GRILEIRTPE AVTSIKKRGE
     SLGYTEGALL ALAFIIILCC IPAILVVLVS YRQFKVRQAE CTKTARIQAA LPAAKPAVPA
     PAPVAAPPPP PPPPPGAHLY EELGDSSMHK YEMPQYGSRR RLLPPAGQEE YGEVVGEAEE
     EYEEEEEEPK KIKKPKVEIR EPSEEEEVVV TIEKPPAAEP TYTTWKRARI FPMIFKKVRG
     LADKRGIVDL EGEEWQRRLE EEDKDYLKLT LDQEEATEST VESEEESSSD YTEYSEEESE
     FSESETTEEE SESETPSEEE ESSTPESEES ESTESEGEKA RKNIVLARRR PMVEEVKEVK
     GRKEEPQEEQ KEPKMEEEEH SEEEESGPAP VEESTDPEAQ DIPEEGSAES ASVEGGVESE
     EESESGSSSS SSESQSGGPW GYQVPAYDRS KNANQKKSPG ANSEGYNTAL
//