ID A0A087WZB4_HUMAN Unreviewed; 751 AA. AC A0A087WZB4; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 05-DEC-2018, entry version 30. DE SubName: Full=Potassium voltage-gated channel subfamily KQT member 3 {ECO:0000313|Ensembl:ENSP00000482510}; GN Name=KCNQ3 {ECO:0000313|Ensembl:ENSP00000482510}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482510, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000482510, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16421571; DOI=10.1038/nature04406; RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., RA Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., RA Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., RA Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T., RA Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., RA DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G., RA Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., RA Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., RA O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K., RA Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., RA Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., RA Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., RA Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., RA Lander E.S.; RT "DNA sequence and analysis of human chromosome 8."; RL Nature 439:331-335(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000482510} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the potassium channel family. CC {ECO:0000256|SAAS:SAAS00692852}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC018540; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC123776; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC131042; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC136373; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A087WZB4; -. DR PeptideAtlas; A0A087WZB4; -. DR Ensembl; ENST00000621976; ENSP00000482510; ENSG00000184156. DR UCSC; uc064qhp.1; human. DR EuPathDB; HostDB:ENSG00000184156.15; -. DR HGNC; HGNC:6297; KCNQ3. DR OpenTargets; ENSG00000184156; -. DR eggNOG; KOG1419; Eukaryota. DR eggNOG; COG1226; LUCA. DR GeneTree; ENSGT00940000159760; -. DR ChiTaRS; KCNQ3; human. DR Proteomes; UP000005640; Chromosome 8. DR Bgee; ENSG00000184156; Expressed in 129 organ(s), highest expression level in caudate nucleus. DR ExpressionAtlas; A0A087WZB4; baseline and differential. DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro. DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro. DR InterPro; IPR020969; Ankyrin-G_BS. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ. DR InterPro; IPR003948; K_chnl_volt-dep_KCNQ3. DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C. DR InterPro; IPR028325; VG_K_chnl. DR PANTHER; PTHR11537; PTHR11537; 1. DR PANTHER; PTHR11537:SF5; PTHR11537:SF5; 1. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF03520; KCNQ_channel; 1. DR Pfam; PF11956; KCNQC3-Ank-G_bd; 1. DR PRINTS; PR00169; KCHANNEL. DR PRINTS; PR01462; KCNQ3CHANNEL. DR PRINTS; PR01459; KCNQCHANNEL. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Ion channel {ECO:0000256|SAAS:SAAS00417246}; KW Ion transport {ECO:0000256|SAAS:SAAS00417246}; KW Membrane {ECO:0000256|SAAS:SAAS00417245, ECO:0000256|SAM:Phobius}; KW Potassium {ECO:0000256|SAAS:SAAS00417246}; KW Potassium channel {ECO:0000256|SAAS:SAAS00417246}; KW Potassium transport {ECO:0000256|SAAS:SAAS00417246}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00417245, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00417245, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417246}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 751 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001832081. FT TRANSMEM 34 56 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 77 94 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 140 161 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 210 236 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 8 232 Ion_trans. {ECO:0000259|Pfam:PF00520}. FT DOMAIN 326 528 KCNQ_channel. {ECO:0000259|Pfam:PF03520}. SQ SEQUENCE 751 AA; 84711 MW; 6ED3FD4BF62053E1 CRC64; KPKKHGPMFL IVLGCLILAV LTTFKEYETV SGDWLLLLET FAIFIFGAEF ALRIWAAGCC CRYKGWRGRL KFARKPLCML DIFVLIASVP VVAVGNQGNV LATSLRSLRF LQILRMLRMD RRGGTWKLLG SAICAHSKEL ITAWYIGFLT LILSSFLVYL VEKDVPEVDA QGEEMKEEFE TYADALWWGL ITLATIGYGD KTPKTWEGRL IAATFSLIGV SFFALPAGIL GSGLALKVQE QHRQKHFEKR RKPAAELIQA AWRYYATNPN RIDLVATWRF YESVVSFPFF RKEQLEAASS QKLGLLDRVR LSNPRGSNTK GKLFTPLNVD AIEESPSKEP KPVGLNNKER FRTAFRMKAY AFWQSSEDAG TGDPMAEDRG YGNDFPIEDM IPTLKAAIRA VRILQFRLYK KKFKETLRPY DVKDVIEQYS AGHLDMLSRI KYLQTRIDMI FTPGPPSTPK HKKSQKGSAF TFPSQQSPRN EPYVARPSTS EIEDQSMMGK FVKVERQVQD MGKKLDFLVD MHMQHMERLQ VQVTEYYPTK GTSSPAEAEK KEDNRYSDLK TIICNYSETG PPEPPYSFHQ VTIDKVSPYG FFAHDPVNLP RGGPSSGKVQ ATPPSSATTY VERPTVLPIL TLLDSRVSCH SQADLQGPYS DRISPRQRRS ITRDSDTPLS LMSVNHEELE RSPSGFSISQ DRDDYVFGPN GGSSWMREKR YLAEGETDTD TDPFTPSGSM PLSSTGDGIS DSVWTPSNKP I //