ID   A0A087WZ93_HUMAN        Unreviewed;       139 AA.
AC   A0A087WZ93;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 23.
DE   SubName: Full=Signal peptide peptidase-like 2B {ECO:0000313|Ensembl:ENSP00000482470};
GN   Name=SPPL2B {ECO:0000313|Ensembl:ENSP00000482470};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482470, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000482470, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000482470}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC004410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WZ93; -.
DR   jPOST; A0A087WZ93; -.
DR   PeptideAtlas; A0A087WZ93; -.
DR   Ensembl; ENST00000621568; ENSP00000482470; ENSG00000005206.
DR   UCSC; uc060rkj.1; human.
DR   EuPathDB; HostDB:ENSG00000005206.16; -.
DR   HGNC; HGNC:30627; SPPL2B.
DR   OpenTargets; ENSG00000005206; -.
DR   GeneTree; ENSGT00940000158753; -.
DR   ChiTaRS; SPPL2B; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000005206; Expressed in 172 organ(s), highest expression level in right uterine tube.
DR   ExpressionAtlas; A0A087WZ93; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro.
DR   GO; GO:0031293; P:membrane protein intracellular domain proteolysis; IEA:InterPro.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007369; Peptidase_A22B_SPP.
DR   InterPro; IPR033149; SPPL2B.
DR   PANTHER; PTHR12174; PTHR12174; 1.
DR   PANTHER; PTHR12174:SF39; PTHR12174:SF39; 1.
DR   Pfam; PF02225; PA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A087WZ93,
KW   ECO:0000213|PeptideAtlas:A0A087WZ93};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    139       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832110.
FT   DOMAIN       72    122       PA. {ECO:0000259|Pfam:PF02225}.
SQ   SEQUENCE   139 AA;  14862 MW;  2DF0306E1DBAF816 CRC64;
     MAAAVAAALA RLLAAFLLLA AQVACEYGMV HVVSQAGGPE GKDYCILYNP QWAHLPHDLS
     KASFLQLRNW TASLLCSAAD LPARGFSNQI PLVARGNCTF YEKVRLAQGS GARGLLIVSR
     ERLLQRHAGH LHGSVSAAR
//