ID   A0A087WZ82_HUMAN        Unreviewed;       144 AA.
AC   A0A087WZ82;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   13-FEB-2019, entry version 34.
DE   RecName: Full=FXYD domain-containing ion transport regulator {ECO:0000256|RuleBase:RU364131};
GN   Name=FXYD6-FXYD2 {ECO:0000313|Ensembl:ENSP00000482442};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482442, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000482442, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000482442}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the FXYD family.
CC       {ECO:0000256|RuleBase:RU364131}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU364131}.
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DR   EMBL; AP000757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001191197.1; NM_001204268.1.
DR   UniGene; Hs.744850; -.
DR   ProteinModelPortal; A0A087WZ82; -.
DR   SMR; A0A087WZ82; -.
DR   BioMuta; FXYD6-FXYD2; -.
DR   PeptideAtlas; A0A087WZ82; -.
DR   PRIDE; A0A087WZ82; -.
DR   Ensembl; ENST00000614497; ENSP00000482442; ENSG00000255245.
DR   GeneID; 100533181; -.
DR   KEGG; hsa:100533181; -.
DR   UCSC; uc021qqy.1; human.
DR   CTD; 100533181; -.
DR   EuPathDB; HostDB:ENSG00000255245.4; -.
DR   GeneCards; FXYD6-FXYD2; -.
DR   HGNC; HGNC:39978; FXYD6-FXYD2.
DR   OpenTargets; ENSG00000255245; -.
DR   GeneTree; ENSGT00940000153062; -.
DR   OrthoDB; 1409318at2759; -.
DR   ChiTaRS; FXYD6-FXYD2; human.
DR   GenomeRNAi; 100533181; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000255245; Expressed in 76 organ(s), highest expression level in adult mammalian kidney.
DR   ExpressionAtlas; A0A087WZ82; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR   GO; GO:0017080; F:sodium channel regulator activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IBA:GO_Central.
DR   InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR   Pfam; PF02038; ATP1G1_PLM_MAT8; 2.
DR   ProDom; PD005989; PD005989; 2.
DR   PROSITE; PS01310; FXYD; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ion transport {ECO:0000256|RuleBase:RU364131};
KW   Membrane {ECO:0000256|RuleBase:RU364131};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU364131};
KW   Transmembrane {ECO:0000256|RuleBase:RU364131};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU364131};
KW   Transport {ECO:0000256|RuleBase:RU364131}.
FT   SIGNAL        1     18       {ECO:0000256|RuleBase:RU364131}.
FT   CHAIN        19    144       FXYD domain-containing ion transport
FT                                regulator.
FT                                {ECO:0000256|RuleBase:RU364131}.
FT                                /FTId=PRO_5011328018.
FT   TRANSMEM     36     57       Helical. {ECO:0000256|RuleBase:RU364131}.
FT   TRANSMEM    109    128       Helical. {ECO:0000256|RuleBase:RU364131}.
SQ   SEQUENCE   144 AA;  16258 MW;  9122B7D23A61495E CRC64;
     MELVLVFLCS LLAPMVLASA AEKEKEMDPF HYDYQTLRIG GLVFAVVLFS VGILLILSRR
     CKCSFNQKPR NRAPESRELK CSHQVEGGSP KGDVDPFYYD YETVRNGGLI FAGLAFIVGL
     LILLSRRFRC GGNKKRRQIN EDEP
//