ID   A0A087WYZ7_HUMAN        Unreviewed;       737 AA.
AC   A0A087WYZ7;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 38.
DE   SubName: Full=Semaphorin-4F {ECO:0000313|Ensembl:ENSP00000482238};
GN   Name=SEMA4F {ECO:0000313|Ensembl:ENSP00000482238};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482238, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000482238, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000482238}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the semaphorin family.
CC       {ECO:0000256|SAAS:SAAS00692871}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   EMBL; AC007387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001258591.1; NM_001271662.1.
DR   UniGene; Hs.25887; -.
DR   ProteinModelPortal; A0A087WYZ7; -.
DR   jPOST; A0A087WYZ7; -.
DR   PeptideAtlas; A0A087WYZ7; -.
DR   PRIDE; A0A087WYZ7; -.
DR   Ensembl; ENST00000611975; ENSP00000482238; ENSG00000135622.
DR   GeneID; 10505; -.
DR   UCSC; uc010ffq.3; human.
DR   CTD; 10505; -.
DR   EuPathDB; HostDB:ENSG00000135622.12; -.
DR   HGNC; HGNC:10734; SEMA4F.
DR   OpenTargets; ENSG00000135622; -.
DR   eggNOG; KOG3611; Eukaryota.
DR   eggNOG; ENOG410XQZC; LUCA.
DR   GeneTree; ENSGT00940000159592; -.
DR   OrthoDB; 64683at2759; -.
DR   GenomeRNAi; 10505; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000135622; Expressed in 159 organ(s), highest expression level in frontal cortex.
DR   ExpressionAtlas; A0A087WYZ7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015512; Semaphorin_4F.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; PTHR11036; 2.
DR   PANTHER; PTHR11036:SF72; PTHR11036:SF72; 2.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 2.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF101912; SSF101912; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00656526};
KW   Membrane {ECO:0000256|SAAS:SAAS00106123, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A087WYZ7,
KW   ECO:0000213|PeptideAtlas:A0A087WYZ7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00106123,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00106123,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     34       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        35    737       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832090.
FT   TRANSMEM    626    647       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    477       Sema. {ECO:0000259|PROSITE:PS51004}.
SQ   SEQUENCE   737 AA;  79980 MW;  A069B3C7DA64EE2E CRC64;
     MPASAARPRP GPGQPTASPF PLLLLAVLSG PVSGRVPRSV PRTSLPISEA DSCLTRFAVP
     HTYNYSVLLV DPASHTLYVG ARDTIFALSL PFSGERPRRI DWMVPEAHRQ NCRKKGKKED
     VSRFQQVERL ESGRGKCPFE PAQRSAAVMA GGVLYAATVK NYLGTEPIIT RAVGRAEDWI
     RTDTLPSWLN APAFVAAVAL SPAEWGDEDG DDEIYFFFTE TSRAFDSYER IKVPRVARVC
     AGDLGGRKTL QQRWTTFLKA DLLCPGPEHG RASSVLQDVA VLRPELGAGT PIFYGIFSSQ
     WEGATISAVC AFRPQDIRTV LNGPFRELKH DCNRGLPVVD NDVPQPRPGE CITNNMKLRH
     FGSSLSLPDR VLTFIRDHPL MDRPVFPADG HPLLVTTDTA YLRVVAHRVT SLSGKEYDVL
     YLGTEDGHLH RAVRIGAQLS VLEDLALFPE PQPVENMKLY HSWLLVGSRT EVTQVNTTNC
     GRLQSCSECI LAQDPVCAWS FRLDECVAHA GEHRGLVQDI ESADVSSLCP KEPGERPVVF
     EVPVATAAHV VLPCSPSSAW ASCVWHQPSG VTALTPRRDG LEVVVTPGAM GAYACECQEG
     GAAHVVAAYS LVWGSQRDAP SRAHTVGAGL AGFFLGILAA SLTLILIGRR QQRRRQRELL
     ARDKVGLDLG APPSGTTSYS QDPPSPSPED ERLPLALAKR GSGFGGFSPP FLLDPCPSPA
     HIRLTGAPLA TCDETSI
//