ID   A0A087WYZ4_HUMAN        Unreviewed;       147 AA.
AC   A0A087WYZ4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 35.
DE   RecName: Full=Glycoprotein hormones alpha chain {ECO:0000256|RuleBase:RU362129};
GN   Name=CGA {ECO:0000313|Ensembl:ENSP00000482232};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482232, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000482232, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000482232}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- SUBUNIT: Heterodimer. The active hormones thyrotropin, lutropin
CC       and follitropin are heterodimers composed of CGA, a common alpha
CC       chain described here and a unique beta chain which confers their
CC       biological specificity to the hormones: TSHB for thyrotropin, LHB
CC       for lutropin and FSHB for follitropin.
CC       {ECO:0000256|RuleBase:RU362129}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362129,
CC       ECO:0000256|SAAS:SAAS00521609}.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit alpha
CC       family. {ECO:0000256|RuleBase:RU362129,
CC       ECO:0000256|SAAS:SAAS00594029}.
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DR   EMBL; AL138827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001239312.1; NM_001252383.1.
DR   UniGene; Hs.119689; -.
DR   ProteinModelPortal; A0A087WYZ4; -.
DR   SMR; A0A087WYZ4; -.
DR   PeptideAtlas; A0A087WYZ4; -.
DR   PRIDE; A0A087WYZ4; -.
DR   Ensembl; ENST00000610310; ENSP00000482232; ENSG00000135346.
DR   GeneID; 1081; -.
DR   UCSC; uc021zci.2; human.
DR   CTD; 1081; -.
DR   EuPathDB; HostDB:ENSG00000135346.8; -.
DR   HGNC; HGNC:1885; CGA.
DR   OpenTargets; ENSG00000135346; -.
DR   GeneTree; ENSGT00390000012242; -.
DR   OrthoDB; 1430707at2759; -.
DR   ChiTaRS; CGA; human.
DR   GenomeRNAi; 1081; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000135346; Expressed in 91 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; A0A087WYZ4; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0032870; P:cellular response to hormone stimulus; IEA:Ensembl.
DR   GO; GO:0048589; P:developmental growth; IEA:Ensembl.
DR   GO; GO:0046884; P:follicle-stimulating hormone secretion; IEA:Ensembl.
DR   GO; GO:0008406; P:gonad development; IEA:Ensembl.
DR   GO; GO:0032275; P:luteinizing hormone secretion; IEA:Ensembl.
DR   GO; GO:0046621; P:negative regulation of organ growth; IEA:Ensembl.
DR   GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR   GO; GO:0006590; P:thyroid hormone generation; IEA:Ensembl.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR000476; Glyco_hormone.
DR   PANTHER; PTHR11509; PTHR11509; 2.
DR   Pfam; PF00236; Hormone_6; 1.
DR   PRINTS; PR00274; GLYCOHORMONE.
DR   SMART; SM00067; GHA; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00779; GLYCO_HORMONE_ALPHA_1; 1.
DR   PROSITE; PS00780; GLYCO_HORMONE_ALPHA_2; 1.
DR   PROSITE; PS50277; GLYCO_HORMONE_ALPHA_3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00521605};
KW   Glycoprotein {ECO:0000256|RuleBase:RU362129};
KW   Hormone {ECO:0000256|RuleBase:RU362129,
KW   ECO:0000256|SAAS:SAAS00135161};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A087WYZ4,
KW   ECO:0000213|PeptideAtlas:A0A087WYZ4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|RuleBase:RU362129,
KW   ECO:0000256|SAAS:SAAS00521604};
KW   Signal {ECO:0000256|RuleBase:RU362129}.
FT   SIGNAL        1     24       {ECO:0000256|RuleBase:RU362129}.
FT   CHAIN        25    147       Glycoprotein hormones alpha chain.
FT                                {ECO:0000256|RuleBase:RU362129}.
FT                                /FTId=PRO_5005391042.
SQ   SEQUENCE   147 AA;  16306 MW;  AEE3CD031FEF95AE CRC64;
     MDYYRKYAAI FLVTLSVFLH VLHSAPDVQE TGFHHVAQAA LKLLSSSNPP TKASQSARIT
     DCPECTLQEN PFFSQPGAPI LQCMGCCFSR AYPTPLRSKK TMLVQKNVTS ESTCCVAKSY
     NRVTVMGGFK VENHTACHCS TCYYHKS
//