ID   A0A087WYX0_HUMAN        Unreviewed;       524 AA.
AC   A0A087WYX0;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 26.
DE   SubName: Full=Carcinoembryonic antigen-related cell adhesion molecule 5 {ECO:0000313|Ensembl:ENSP00000482157};
GN   Name=CEACAM5 {ECO:0000313|Ensembl:ENSP00000482157};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482157, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000482157, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000482157}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC243967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WYX0; -.
DR   jPOST; A0A087WYX0; -.
DR   PeptideAtlas; A0A087WYX0; -.
DR   Ensembl; ENST00000615021; ENSP00000482157; ENSG00000105388.
DR   UCSC; uc032hya.2; human.
DR   EuPathDB; HostDB:ENSG00000105388.15; -.
DR   HGNC; HGNC:1817; CEACAM5.
DR   OpenTargets; ENSG00000105388; -.
DR   GeneTree; ENSGT00940000153087; -.
DR   ChiTaRS; CEACAM5; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000105388; Expressed in 131 organ(s), highest expression level in colonic mucosa.
DR   ExpressionAtlas; A0A087WYX0; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   Gene3D; 2.60.40.10; -; 5.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF13895; Ig_2; 2.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 5.
DR   SMART; SM00408; IGc2; 4.
DR   SUPFAM; SSF48726; SSF48726; 5.
DR   PROSITE; PS50835; IG_LIKE; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A087WYX0,
KW   ECO:0000213|PeptideAtlas:A0A087WYX0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     34       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        35    524       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832049.
FT   DOMAIN      145    232       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      240    317       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      323    410       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      415    497       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   524 AA;  57231 MW;  B8C5200499014EA2 CRC64;
     MESPSAPPHR WCIPWQRLLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE VLLLVHNLPQ
     HLFGYSWYKG ERVDGNRQII GYVIGTQQAT PGPAYSGREI IYPNASLLIQ NIIQNDTGFY
     TLHVIKSDLV NEEATGQFRV YPEPPKPFIT SNNSNPVEDE DAVALTCEPE IQNTTYLWWV
     NNQSLPVSPR LQLSNDNRTL TLLSVTRNDV GPYECGIQNE LSVDHSDPVI LNVLYGPDDP
     TISPSYTYYR PGVNLSLSCH AASNPPAQYS WLIDGNIQQH TQELFISNIT EKNSGLYTCQ
     ANNSASGHSR TTVKTITVSA ELPKPSISSN NSKPVEDKDA VAFTCEPEAQ NTTYLWWVNG
     QSLPVSPRLQ LSNGNRTLTL FNVTRNDARA YVCGIQNSVS ANRSDPVTLD VLYGPDTPII
     SPPDSSYLSG ANLNLSCHSA SNPSPQYSWR INGIPQQHTQ VLFIAKITPN NNGTYACFVS
     NLATGRNNSI VKSITVSASG TSPGLSAGAT VGIMIGVLVG VALI
//