ID A0A087WYV8_HUMAN Unreviewed; 2911 AA. AC A0A087WYV8; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 13-FEB-2019, entry version 42. DE SubName: Full=Fibrillin-2 {ECO:0000313|Ensembl:ENSP00000482132}; GN Name=FBN2 {ECO:0000313|Ensembl:ENSP00000482132}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482132, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000482132, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000482132} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC025169; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC034235; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC113387; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC114276; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF510259; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A087WYV8; -. DR jPOST; A0A087WYV8; -. DR PeptideAtlas; A0A087WYV8; -. DR Ensembl; ENST00000619499; ENSP00000482132; ENSG00000138829. DR UCSC; uc063gqj.1; human. DR EuPathDB; HostDB:ENSG00000138829.10; -. DR HGNC; HGNC:3604; FBN2. DR OpenTargets; ENSG00000138829; -. DR eggNOG; ENOG410IR7H; Eukaryota. DR eggNOG; ENOG410XSTY; LUCA. DR GeneTree; ENSGT00940000153951; -. DR ChiTaRS; FBN2; human. DR Proteomes; UP000005640; Chromosome 5. DR Bgee; ENSG00000138829; Expressed in 146 organ(s), highest expression level in placenta. DR ExpressionAtlas; A0A087WYV8; baseline and differential. DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro. DR Gene3D; 3.90.290.10; -; 9. DR InterPro; IPR026823; cEGF. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR011398; FBN. DR InterPro; IPR040872; Fibrillin_U_N. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR017878; TB_dom. DR InterPro; IPR036773; TB_dom_sf. DR PANTHER; PTHR24039; PTHR24039; 1. DR Pfam; PF12662; cEGF; 2. DR Pfam; PF07645; EGF_CA; 39. DR Pfam; PF18193; Fibrillin_U_N; 1. DR Pfam; PF12661; hEGF; 2. DR Pfam; PF00683; TB; 9. DR SMART; SM00181; EGF; 46. DR SMART; SM00179; EGF_CA; 44. DR SUPFAM; SSF57184; SSF57184; 13. DR SUPFAM; SSF57581; SSF57581; 9. DR PROSITE; PS00010; ASX_HYDROXYL; 43. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01186; EGF_2; 27. DR PROSITE; PS50026; EGF_3; 45. DR PROSITE; PS01187; EGF_CA; 17. DR PROSITE; PS51364; TB; 9. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00032677}; KW Proteomics identification {ECO:0000213|EPD:A0A087WYV8, KW ECO:0000213|MaxQB:A0A087WYV8, ECO:0000213|PeptideAtlas:A0A087WYV8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00594563}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 2911 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001832085. FT DOMAIN 176 207 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 213 256 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 275 316 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 317 358 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 363 416 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 493 533 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 534 573 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 574 615 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 616 656 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 657 697 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 703 755 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 767 808 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 809 850 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 851 890 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 895 934 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 954 995 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1000 1051 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 1072 1113 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1114 1156 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1157 1198 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1199 1240 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1241 1281 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1282 1323 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1324 1361 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1366 1406 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1407 1447 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1448 1489 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1490 1526 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1531 1571 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1576 1632 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 1649 1690 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1691 1732 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1737 1790 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 1807 1848 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1849 1890 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1891 1928 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1933 1968 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1972 2014 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 2015 2054 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 2055 2096 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 2101 2154 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 2170 2211 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 2212 2251 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 2252 2288 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 2293 2336 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 2337 2374 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 2383 2436 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 2448 2485 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 2490 2530 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 2531 2567 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 2570 2612 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 2613 2652 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 2653 2689 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 2694 2733 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DISULFID 180 190 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 197 206 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 538 548 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 855 865 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1937 1947 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 2617 2627 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 2911 AA; 314677 MW; A73F26561F1C909E CRC64; MGRRRRLCLQ LYFLWLGCVV LWAQGTAGQP QPPPPKPPRP QPPPQQVRSA TAGSEGGFLA PEYREEGAAV ASRVRRRGQQ DVLRGPNVCG SRFHSYCCPG WKTLPGGNQC IVPICRNSCG DGFCSRPNMC TCSSGQISST CGSKSIQQCS VRCMNGGTCA DDHCQCQKGY IGTYCGQPVC ENGCQNGGRC ITQPCACVYG FTGPQCERDY RTGPCFTQVN NQMCQGQLTG IVCTKTLCCA TIGRAWGHPC EMCPAQPQPC RRGFIPNIRT GACQDVDECQ AIPGICQGGN CINTVGSFEC RCPAGHKQSE TTQKCEDIDE CSIIPGICET GECSNTVGSY FCVCPRGYVT STDGSRCIDQ RTGMCFSGLV NGRCAQELPG RMTKMQCCCE PGRCWGIGTI PEACPVRGSE EYRRLCMDGL PMGGIPGSAG SRPGGTGGNG FAPSGNGNGY GPGGTGFIPI PGGNGFSPGV GGAGVGAGGQ GPIITGLTIL NQTIDICKHH ANLCLNGRCI PTVSSYRCEC NMGYKQDANG DCIDVDECTS NPCTNGDCVN TPGSYYCKCH AGFQRTPTKQ ACIDIDECIQ NGVLCKNGRC VNTDGSFQCI CNAGFELTTD GKNCVDHDEC TTTNMCLNGM CINEDGSFKC ICKPGFVLAP NGRYCTDVDE CQTPGICMNG HCINSEGSFR CDCPPGLAVG MDGRVCVDTH MRSTCYGGIK KGVCVRPFPG AVTKSECCCA NPDYGFGEPC QPCPAKNSAE FHGLCSSGVG ITVDGRDINE CALDPDICAN GICENLRGSY RCNCNSGYEP DASGRNCIDI DECLVNRLLC DNGLCRNTPG SYSCTCPPGY VFRTETETCE DINECESNPC VNGACRNNLG SFNCECSPGS KLSSTGLICI DSLKGTCWLN IQDSRCEVNI NGATLKSECC ATLGAAWGSP CERCELDTAC PRGLARIKGV TCEDVNECEV FPGVCPNGRC VNSKGSFHCE CPEGLTLDGT GRVCLDIRME QCYLKWDEDE CIHPVPGKFR MDACCCAVGA AWGTECEECP KPGTKEYETL CPRGAGFANR GDVLTGRPFY KDINECKAFP GMCTYGKCRN TIGSFKCRCN SGFALDMEER NCTDIDECRI SPDLCGSGIC VNTPGSFECE CFEGYESGFM MMKNCMDIDE CERNPLLCRG GTCVNTEGSF QCDCPLGHEL SPSREDCVDI NECSLSDNLC RNGKCVNMIG TYQCSCNPGY QATPDRQGCT DIDECMIMNG GCDTQCTNSE GSYECSCSEG YALMPDGRSC ADIDECENNP DICDGGQCTN IPGEYRCLCY DGFMASMDMK TCIDVNECDL NSNICMFGEC ENTKGSFICH CQLGYSVKKG TTGCTDVDEC EIGAHNCDMH ASCLNIPGSF KCSCREGWIG NGIKCIDLDE CSNGTHQCSI NAQCVNTPGS YRCACSEGFT GDGFTCSDVD ECAENINLCE NGQCLNVPGA YRCECEMGFT PASDSRSCQD IDECSFQNIC VFGTCNNLPG MFHCICDDGY ELDRTGGNCT DIDECADPIN CVNGLCVNTP GRYECNCPPD FQLNPTGVGC VDNRVGNCYL KFGPRGDGSL SCNTEIGVGV SRSSCCCSLG KAWGNPCETC PPVNSTEYYT LCPGGEGFRP NPITIILEDI DECQELPGLC QGGNCINTFG SFQCECPQGY YLSEDTRICE DIDECFAHPG VCGPGTCYNT LGNYTCICPP EYMQVNGGHN CMDMRKSFCY RSYNGTTCEN ELPFNVTKRM CCCTYNVGKA WNKPCEPCPT PGTADFKTIC GNIPGFTFDI HTGKAVDIDE CKEIPGICAN GVCINQIGSF RCECPTGFSY NDLLLVCEDI DECSNGDNLC QRNADCINSP GSYRCECAAG FKLSPNGACV DRNECLEIPN VCSHGLCVDL QGSYQCICHN GFKASQDQTM CMDVDECERH PCGNGTCKNT VGSYNCLCYP GFELTHNNDC LDIDECSSFF GQVCRNGRCF NEIGSFKCLC NEGYELTPDG KNCIDTNECV ALPGSCSPGT CQNLEGSFRC ICPPGYEVKS ENCIDINECD EDPNICLFGS CTNTPGGFQC LCPPGFVLSD NGRRCFDTRQ SFCFTNFENG KCSVPKAFNT TKAKCCCSKM PGEGWGDPCE LCPKDDEVAF QDLCPYGHGT VPSLHDTRED VNECLESPGI CSNGQCINTD GSFRCECPMG YNLDYTGVRC VDTDECSIGN PCGNGTCTNV IGSFECNCNE GFEPGPMMNC EDINECAQNP LLCAFRCMNT FGSYECTCPI GYALREDQKM CKDLDECAEG LHDCESRGMM CKNLIGTFMC ICPPGMARRP DGEGCVDENE CRTKPGICEN GRCVNIIGSY RCECNEGFQS SSSGTECLDN RQGLCFAEVL QTICQMASSS RNLVTKSECC CDGGRGWGHQ CELCPLPGTA QYKKICPHGP GYTTDGRDID ECKVMPNLCT NGQCINTMGS FRCFCKVGYT TDISGTSCID LDECSQSPKP CNYICKNTEG SYQCSCPRGY VLQEDGKTCK DLDECQTKQH NCQFLCVNTL GGFTCKCPPG FTQHHTACID NNECGSQPSL CGAKGICQNT PGSFSCECQR GFSLDATGLN CEDVDECDGN HRCQHGCQNI LGGYRCGCPQ GYIQHYQWNQ CVDENECSNP NACGSASCYN TLGSYKCACP SGFSFDQFSS ACHDVNECSS SKNPCNYGCS NTEGGYLCGC PPGYYRVGQG HCVSGMGFNK GQYLSLDTEV DEENALSPEA CYECKINGYS KKDSRQKRSI HEPDPTAVEQ ISLESVDMDS PVNMKFNLSH LGSKEHILEL RPAIQPLNNH IRYVISQGND DSVFRIHQRN GLSYLHTAKK KLMPGTYTLE ITSIPLYKKK ELKKLEESNE DDYLLGELGE ALRMRLQIQL Y //