ID   A0A087WYR8_HUMAN        Unreviewed;      1381 AA.
AC   A0A087WYR8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 2.
DT   16-JAN-2019, entry version 33.
DE   SubName: Full=Cadherin-23 {ECO:0000313|Ensembl:ENSP00000482036};
GN   Name=CDH23 {ECO:0000313|Ensembl:ENSP00000482036};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482036, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000482036, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000482036}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC012469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL359183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL731541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL772287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001165401.1; NM_001171930.1.
DR   UniGene; Hs.656032; -.
DR   SMR; A0A087WYR8; -.
DR   PeptideAtlas; A0A087WYR8; -.
DR   PRIDE; A0A087WYR8; -.
DR   Ensembl; ENST00000616684; ENSP00000482036; ENSG00000107736.
DR   GeneID; 64072; -.
DR   UCSC; uc057twl.1; human.
DR   CTD; 64072; -.
DR   EuPathDB; HostDB:ENSG00000107736.19; -.
DR   HGNC; HGNC:13733; CDH23.
DR   OpenTargets; ENSG00000107736; -.
DR   GeneTree; ENSGT00940000155245; -.
DR   OrthoDB; 17702at2759; -.
DR   ChiTaRS; CDH23; human.
DR   GenomeRNAi; 64072; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000107736; Expressed in 110 organ(s), highest expression level in right hemisphere of cerebellum.
DR   ExpressionAtlas; A0A087WYR8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0032420; C:stereocilium; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0060122; P:inner ear receptor cell stereocilium organization; IEA:InterPro.
DR   GO; GO:0007626; P:locomotory behavior; IEA:InterPro.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR033030; CDH23.
DR   PANTHER; PTHR43956:SF3; PTHR43956:SF3; 1.
DR   Pfam; PF00028; Cadherin; 12.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 12.
DR   SUPFAM; SSF49313; SSF49313; 12.
DR   PROSITE; PS00232; CADHERIN_1; 4.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087WYR8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24   1381       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5006541695.
FT   DOMAIN       55    130       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      154    234       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      258    346       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      371    458       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      482    559       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      583    669       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      693    776       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      800    888       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      912    993       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1017   1100       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1124   1206       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1231   1311       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   1381 AA;  152248 MW;  F19DF9E5A9301A18 CRC64;
     MGRHVATSCH VAWLLVLISG CWGQVNRLPF FTNHFFDTYL LISEDTPVGS SVTQLLAQDM
     DNDPLVFGVS GEEASRFFAV EPDTGVVWLR QPLDRETKSE FTVEFSVSDH QGVITRKVNI
     QVGDVNDNAP TFHNQPYSVR IPENTPVGTP IFIVNATDPD LGAGGSVLYS FQPPSQFFAI
     DSARGIVTVI RELDYETTQA YQLTVNATDQ DKTRPLSTLA NLAIIITDVQ DMDPIFINLP
     YSTNIYEHSP PGTTVRIITA IDQDKGRPRG IGYTIVSGNT NSIFALDYIS GVLTLNGLLD
     RENPLYSHGF ILTVKGTELN DDRTPSDATV TTTFNILVID INDNAPEFNS SEYSVAITEL
     AQVGFALPLF IQVVDKDENL GLNSMFEVYL VGNNSHHFII SPTSVQGKAD IRIRVAIPLD
     YETVDRYDFD LFANESVPDH VGYAKVKITL INENDNRPIF SQPLYNISLY ENVTVGTSVL
     TVLATDNDAG TFGEVSYFFS DDPDRFSLDK DTGLIMLIAR LDYELIQRFT LTIIARDGGG
     EETTGRVRIN VLDVNDNVPT FQKDAYVGAL RENEPSVTQL VRLRATDEDS PPNNQITYSI
     VSASAFGSYF DISLYEGYGV ISVSRPLDYE QISNGLIYLT VMAMDAGNPP LNSTVPVTIE
     VFDENDNPPT FSKPAYFVSV VENIMAGATV LFLNATDLDR SREYGQESII YSLEGSTQFR
     INARSGEITT TSLLDRETKS EYILIVRAVD GGVGHNQKTG IATVNITLLD INDNHPTWKD
     APYYINLVEM TPPDSDVTTV VAVDPDLGEN GTLVYSIQPP NKFYSLNSTT GKIRTTHAML
     DRENPDPHEA ELMRKIVVSV TDCGRPPLKA TSSATVFVNL LDLNDNDPTF QNLPFVAEVL
     EGIPAGVSIY QVVAIDLDEG LNGLVSYRMP VGMPRMDFLI NSSSGVVVTT TELDRERIAE
     YQLRVVASDA GTPTKSSTST LTIHVLDVND ETPTFFPAVY NVSVSEDVPR EFRVVWLNCT
     DNDVGLNAEL SYFITGGNVD GKFSVGYRDA VVRTVVGLDR ETTAAYMLIL EAIDNGPVGK
     RHTGTATVFV TVLDVNDNRP IFLQSSYEAS VPEDIPEGHS ILQLKATDAD EGEFGRVWYR
     ILHGNHGNNF RIHVSNGLLM RGPRPLDRER NSSHVLIVEA YNHDLGPMRS SVRVIVYVED
     INDEAPVFTQ QQYSRLGLRE TAGIGTSVIV VQATDRDSGD GGLVNYRILS GAEGKFEIDE
     STGLIITVNY LDYETKTSYM MNVSATDQAP PFNQGFCSVY ITLLNELDEA VQFSNASYEA
     AILENLALGT EIVRVQAYSI DNLNQITYRF NAYTSTQAKA LFKIDAITVR GWGQGAPFLP
     I
//