ID   A0A087WYL5_HUMAN        Unreviewed;       923 AA.
AC   A0A087WYL5;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 39.
DE   SubName: Full=Seizure 6-like protein 2 {ECO:0000313|Ensembl:ENSP00000481917};
GN   Name=SEZ6L2 {ECO:0000313|Ensembl:ENSP00000481917};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000481917, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000481917, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000481917}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; AC120114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001230261.1; NM_001243332.1.
DR   UniGene; Hs.6314; -.
DR   ProteinModelPortal; A0A087WYL5; -.
DR   EPD; A0A087WYL5; -.
DR   jPOST; A0A087WYL5; -.
DR   PRIDE; A0A087WYL5; -.
DR   Ensembl; ENST00000617533; ENSP00000481917; ENSG00000174938.
DR   GeneID; 26470; -.
DR   UCSC; uc010vec.3; human.
DR   CTD; 26470; -.
DR   EuPathDB; HostDB:ENSG00000174938.14; -.
DR   HGNC; HGNC:30844; SEZ6L2.
DR   OpenTargets; ENSG00000174938; -.
DR   eggNOG; ENOG410IJTP; Eukaryota.
DR   eggNOG; ENOG410ZD9C; LUCA.
DR   GeneTree; ENSGT00940000160492; -.
DR   OMA; WQIHGNE; -.
DR   OrthoDB; 126806at2759; -.
DR   ChiTaRS; SEZ6L2; human.
DR   GenomeRNAi; 26470; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000174938; Expressed in 192 organ(s), highest expression level in cerebellum.
DR   ExpressionAtlas; A0A087WYL5; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR   GO; GO:0021680; P:cerebellar Purkinje cell layer development; IEA:Ensembl.
DR   GO; GO:0090036; P:regulation of protein kinase C signaling; IEA:Ensembl.
DR   GO; GO:0060074; P:synapse maturation; IEA:Ensembl.
DR   CDD; cd00033; CCP; 5.
DR   CDD; cd00041; CUB; 3.
DR   Gene3D; 2.60.120.290; -; 3.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   Pfam; PF00431; CUB; 1.
DR   Pfam; PF00084; Sushi; 5.
DR   SMART; SM00032; CCP; 5.
DR   SMART; SM00042; CUB; 3.
DR   SUPFAM; SSF49854; SSF49854; 3.
DR   SUPFAM; SSF57535; SSF57535; 5.
DR   PROSITE; PS01180; CUB; 3.
DR   PROSITE; PS50923; SUSHI; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00059,
KW   ECO:0000256|SAAS:SAAS00887447}; Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A087WYL5,
KW   ECO:0000213|MaxQB:A0A087WYL5, ECO:0000213|PeptideAtlas:A0A087WYL5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    923       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832088.
FT   TRANSMEM    858    880       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      173    286       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      288    347       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      349    459       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      462    525       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      527    638       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      642    701       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      703    766       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      769    830       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DISULFID    349    376       {ECO:0000256|PROSITE-ProRule:PRU00059}.
FT   DISULFID    672    699       {ECO:0000256|PROSITE-ProRule:PRU00302}.
SQ   SEQUENCE   923 AA;  99134 MW;  999CF237DA7E6744 CRC64;
     MGTPRAQHPP PPQLLFLILL SCPWIQGLPL KEEEILPEPG SETPTVASEA LAELLHGALL
     RRGPEMGYLP GSDRDPTLAT PPAGQTLAVP SLPRATEPGT GPLTTAVTPN GVRGAGPTAP
     ELLTPPPGTT APPPPSPASP GPPLGPEGGE EETTTTIITT TTVTTTVTSP VLCNNNISEG
     EGYVESPDLG SPVSRTLGLL DCTYSIHVYP GYGIEIQVQT LNLSQEEELL VLAGGGSPGL
     APRLLANSSM LGEGQVLRSP TNRLLLHFQS PRVPRGGGFR IHYQAYLLSC GFPPRPAHGD
     VSVTDLHPGG TATFHCDSGY QLQGEETLIC LNGTRPSWNG ETPSCMASCG GTIHNATLGR
     IVSPEPGGAV GPNLTCRWVI EAAEGRRLHL HFERVSLDED NDRLMVRSGG SPLSPVIYDS
     DMDDVPERGL ISDAQSLYVE LLSETPANPL LLSLRFEAFE EDRCFAPFLA HGNVTTTDPE
     YRPGALATFS CLPGYALEPP GPPNAIECVD PTEPHWNDTE PACKAMCGGE LSEPAGVVLS
     PDWPQSYSPG QDCVWGVHVQ EEKRILLQVE ILNVREGDML TLFDGDGPSA RVLAQLRGPQ
     PRRRLLSSGP DLTLQFQAPP GPPNPGLGQG FVLHFKEVPR NDTCPELPPP EWGWRTASHG
     DLIRGTVLTY QCEPGYELLG SDILTCQWDL SWSAAPPACQ KIMTCADPGE IANGHRTASD
     AGFPVGSHVQ YRCLPGYSLE GAAMLTCYSR DTGTPKWSDR VPKCALKYEP CLNPGVPENG
     YQTLYKHHYQ AGESLRFFCY EGFELIGEVT ITCVPGHPSQ WTSQPPLCKV AYEELLDNRK
     LEVTQTTDPS RQLEGGNLAL AILLPLGLVI VLGSGVYIYY TKLQGKSLFG FSGSHSYSPI
     TVESDFSNPL YEAGDTREYE VSI
//