ID   A0A087WYL3_HUMAN        Unreviewed;       719 AA.
AC   A0A087WYL3;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 34.
DE   SubName: Full=Interphotoreceptor matrix proteoglycan 1 {ECO:0000313|Ensembl:ENSP00000481913};
GN   Name=IMPG1 {ECO:0000313|Ensembl:ENSP00000481913};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000481913, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000481913, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000481913}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AL356962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL392166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001269297.1; NM_001282368.1.
DR   UniGene; Hs.590893; -.
DR   PeptideAtlas; A0A087WYL3; -.
DR   PRIDE; A0A087WYL3; -.
DR   Ensembl; ENST00000611179; ENSP00000481913; ENSG00000112706.
DR   GeneID; 3617; -.
DR   UCSC; uc032xbg.2; human.
DR   CTD; 3617; -.
DR   EuPathDB; HostDB:ENSG00000112706.11; -.
DR   HGNC; HGNC:6055; IMPG1.
DR   OpenTargets; ENSG00000112706; -.
DR   eggNOG; ENOG410IH0G; Eukaryota.
DR   eggNOG; ENOG410Y9FF; LUCA.
DR   GeneTree; ENSGT00530000063503; -.
DR   OrthoDB; 112459at2759; -.
DR   ChiTaRS; IMPG1; human.
DR   GenomeRNAi; 3617; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000112706; Expressed in 87 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; A0A087WYL3; baseline and differential.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   Gene3D; 3.30.70.960; -; 2.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR039861; IMPG.
DR   InterPro; IPR000082; SEA_dom.
DR   InterPro; IPR036364; SEA_dom_sf.
DR   PANTHER; PTHR12199; PTHR12199; 1.
DR   Pfam; PF01390; SEA; 2.
DR   SMART; SM00200; SEA; 2.
DR   SUPFAM; SSF82671; SSF82671; 2.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS50024; SEA; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087WYL3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    719       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832091.
FT   DOMAIN      154    276       SEA. {ECO:0000259|PROSITE:PS50024}.
FT   DOMAIN      493    606       SEA. {ECO:0000259|PROSITE:PS50024}.
FT   DOMAIN      606    644       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DISULFID    615    632       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   719 AA;  80147 MW;  547304511C058F3A CRC64;
     MYLETRRAIF VFWIFLQVQG TKVCQEAVWE AYRIFLDRIP DTGEYQDWVS ICQQETFCLF
     DIGKNFSNSQ EHLDLLQQRI KQRSFPDRKD EISAEKTLGE PGETIVISTD VANVSLGPFP
     LTPDDTLLNE ILDNTLNDTK MPTTERETEF AVLEEQRVEL SVSLVNQKFK AELADSQSPY
     YQELAGKSQL QMQKIFKKLP GFKKIHVLGF RPKKEKDGSS STEMQLTAIF KRHSAEAKSP
     ASDLLSFDSN KIESEEVYHG TMEEDKQPEI YLTATDLKRL ISKALEEEQS LDVGTIQFTD
     EIAGSLPAFG PDTQSELPTS FAVITEDATL SPELPPVEPQ LETVDGAEHG LPDTSWSPPA
     MASTSLSEAP PFFMASSIFS LTDQGTTDTM ATDQTMLVPG LTIPTSDYSA ISQLALGISH
     PPASSDDSRS SAGGEDMVRH LDEMDLSDTP APSEVPELSE YVSVPDHFLE DTTPVSALQY
     ITTSSMTIAP KGRELVVFFS LRVANMAFSN DLFNKSSLEY RALEQQFTQL LVPYLRSNLT
     GFKQLEILNF RNGSVIVNSK MKFAKSVPYN LTKAVHGVLE DFRSAAAQQL HLEIDSYSLN
     IEPADQADPC KFLACGEFAQ CVKNERTEEA ECRCKPGYDS QGSLDGLEPG LCGPGTKECE
     VLQGKGAPCR LPDHSENQAY KTSVKKFQNQ QNNKVISKRN SELLTVEYEE FNHQDWEGN
//