ID A0A087WYF1_HUMAN Unreviewed; 3118 AA. AC A0A087WYF1; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 16-JAN-2019, entry version 43. DE SubName: Full=Laminin subunit alpha-2 {ECO:0000313|Ensembl:ENSP00000481744}; GN Name=LAMA2 {ECO:0000313|Ensembl:ENSP00000481744}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000481744, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000481744, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000481744} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL356124; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL445439; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL513527; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL583853; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL589927; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL590613; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL669984; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458292; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A087WYF1; -. DR jPOST; A0A087WYF1; -. DR PeptideAtlas; A0A087WYF1; -. DR Ensembl; ENST00000617695; ENSP00000481744; ENSG00000196569. DR UCSC; uc063rgw.1; human. DR EuPathDB; HostDB:ENSG00000196569.11; -. DR HGNC; HGNC:6482; LAMA2. DR OpenTargets; ENSG00000196569; -. DR eggNOG; KOG1836; Eukaryota. DR eggNOG; ENOG410XRDC; LUCA. DR GeneTree; ENSGT00940000155362; -. DR ChiTaRS; LAMA2; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000196569; Expressed in 221 organ(s), highest expression level in esophagus. DR ExpressionAtlas; A0A087WYF1; baseline and differential. DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro. DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro. DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro. DR Gene3D; 2.60.120.1490; -; 1. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR009254; Laminin_aI. DR InterPro; IPR010307; Laminin_dom_II. DR InterPro; IPR002049; Laminin_EGF. DR InterPro; IPR001791; Laminin_G. DR InterPro; IPR000034; Laminin_IV. DR InterPro; IPR008211; Laminin_N. DR InterPro; IPR038684; Laminin_N_sf. DR Pfam; PF00052; Laminin_B; 2. DR Pfam; PF00053; Laminin_EGF; 16. DR Pfam; PF00054; Laminin_G_1; 4. DR Pfam; PF02210; Laminin_G_2; 1. DR Pfam; PF06008; Laminin_I; 1. DR Pfam; PF06009; Laminin_II; 1. DR Pfam; PF00055; Laminin_N; 1. DR SMART; SM00181; EGF; 8. DR SMART; SM00180; EGF_Lam; 16. DR SMART; SM00281; LamB; 2. DR SMART; SM00282; LamG; 5. DR SMART; SM00136; LamNT; 1. DR SUPFAM; SSF49899; SSF49899; 5. DR SUPFAM; SSF57184; SSF57184; 1. DR PROSITE; PS01248; EGF_LAM_1; 6. DR PROSITE; PS50027; EGF_LAM_2; 15. DR PROSITE; PS50025; LAM_G_DOMAIN; 5. DR PROSITE; PS51115; LAMININ_IVA; 2. DR PROSITE; PS51117; LAMININ_NTER; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00122, KW ECO:0000256|SAAS:SAAS00814887}; KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460}; KW Proteomics identification {ECO:0000213|MaxQB:A0A087WYF1, KW ECO:0000213|PeptideAtlas:A0A087WYF1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00966518}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 3118 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001832038. FT DOMAIN 35 286 Laminin N-terminal. FT {ECO:0000259|PROSITE:PS51117}. FT DOMAIN 287 343 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 344 413 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 414 468 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 469 517 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 538 723 Laminin IV type A. FT {ECO:0000259|PROSITE:PS51115}. FT DOMAIN 757 806 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 807 864 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 865 917 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 918 966 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 967 1013 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1014 1059 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1060 1105 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1106 1165 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1180 1379 Laminin IV type A. FT {ECO:0000259|PROSITE:PS51115}. FT DOMAIN 1420 1468 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1469 1526 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1527 1573 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 2145 2328 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 2340 2517 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 2522 2706 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 2759 2930 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 2935 3115 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT COILED 1633 1653 {ECO:0000256|SAM:Coils}. FT COILED 1682 1702 {ECO:0000256|SAM:Coils}. FT COILED 1707 1757 {ECO:0000256|SAM:Coils}. FT COILED 1762 1785 {ECO:0000256|SAM:Coils}. FT COILED 1811 1845 {ECO:0000256|SAM:Coils}. FT COILED 1867 1887 {ECO:0000256|SAM:Coils}. FT COILED 1931 1955 {ECO:0000256|SAM:Coils}. FT COILED 1981 2008 {ECO:0000256|SAM:Coils}. FT COILED 2034 2075 {ECO:0000256|SAM:Coils}. FT COILED 2092 2140 {ECO:0000256|SAM:Coils}. FT DISULFID 309 318 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 381 390 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 414 426 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 444 453 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 488 497 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 776 785 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 835 844 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 889 898 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 901 915 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 918 930 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 920 937 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 939 948 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 967 979 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 987 996 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1032 1041 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1060 1072 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1062 1079 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1081 1090 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1106 1118 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1136 1145 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1439 1448 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1497 1506 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1527 1539 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1529 1546 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1548 1557 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 2679 2706 {ECO:0000256|PROSITE-ProRule:PRU00122}. SQ SEQUENCE 3118 AA; 343418 MW; F02D0A799681B275 CRC64; MPGAAGVLLL LLLSGGLGGV QAQRPQQQRQ SQAHQQRGLF PAVLNLASNA LITTNATCGE KGPEMYCKLV EHVPGQPVRN PQCRICNQNS SNPNQRHPIT NAIDGKNTWW QSPSIKNGIE YHYVTITLDL QQVFQIAYVI VKAANSPRPG NWILERSLDD VEYKPWQYHA VTDTECLTLY NIYPRTGPPS YAKDDEVICT SFYSKIHPLE NGEIHISLIN GRPSADDPSP ELLEFTSARY IRLRFQRIRT LNADLMMFAH KDPREIDPIV TRRYYYSVKD ISVGGMCICY GHARACPLDP ATNKSRCECE HNTCGDSCDQ CCPGFHQKPW RAGTFLTKTE CEACNCHGKA EECYYDENVA RRNLSLNIRG KYIGGGVCIN CTQNTAGINC ETCTDGFFRP KGVSPNYPRP CQPCHCDPIG SLNEVCVKDE KHARRGLAPG SCHCKTGFGG VSCDRCARGY TGYPDCKACN CSGLGSKNED PCFGPCICKE NVEGGDCSRC KSGFFNLQED NWKGCDECFC SGVSNRCQSS YWTYGKIQDM SGWYLTDLPG RIRVAPQQDD LDSPQQISIS NAEARQALPH SYYWSAPAPY LGNKLPAVGG QLTFTISYDL EEEEEDTERV LQLMIILEGN DLSISTAQDE VYLHPSEEHT NVLLLKEESF TIHGTHFPVR RKEFMTVLAN LKRVLLQITY SFGMDAIFRL SSVNLESAVS YPTDGSIAAA VEVCQCPPGY TGSSCESCWP RHRRVNGTIF GGICEPCQCF GHAESCDDVT GECLNCKDHT GGPYCDKCLP GFYGEPTKGT SEDCQPCACP LNIPSNNFSP TCHLDRSLGL ICDGCPVGYT GPRCERCAEG YFGQPSVPGG SCQPCQCNDN LDFSIPGSCD SLSGSCLICK PGTTGRYCEL CADGYFGDAV DAKNCQPCRC NAGGSFSEVC HSQTGQCECR ANVQGQRCDK CKAGTFGLQS ARGCVPCNCN SFGSKSFDCE ESGQCWCQPG VTGKKCDRCA HGYFNFQEGG CTACECSHLG NNCDPKTGRC ICPPNTIGEK CSKCAPNTWG HSITTGCKAC NCSTVGSLDF QCNVNTGQCN CHPKFSGAKC TECSRGHWNY PRCNLCDCFL PGTDATTCDS ETKKCSCSDQ TGQCTCKVNV EGIHCDRCRP GKFGLDAKNP LGCSSCYCFG TTTQCSEAKG LIRTWVTLKA EQTILPLVDE ALQHTTTKGI VFQHPEIVAH MDLMREDLHL EPFYWKLPEQ FEGKKLMAYG GKLKYAIYFE AREETGFSTY NPQVIIRGGT PTHARIIVRH MAAPLIGQLT RHEIEMTEKE WKYYGDDPRV HRTVTREDFL DILYDIHYIL IKATYGNFMR QSRISEISME VAEQGRGTTM TPPADLIEKC DCPLGYSGLS CEACLPGFYR LRSQPGGRTP GPTLGTCVPC QCNGHSSLCD PETSICQNCQ HHTAGDFCER CALGYYGIVK GLPNDCQQCA CPLISSSNNF SPSCVAEGLD DYRCTACPRG YEGQYCERCA PGYTGSPGNP GGSCQECECD PYGSLPVPCD PVTGFCTCRP GATGRKCDGC KHWHAREGWE CVFCGDECTG LLLGDLARLE QMVMSINLTG PLPAPYKMLY GLENMTQELK HLLSPQRAPE RLIQLAEGNL NTLVTEMNEL LTRATKVTAD GEQTGQDAER TNTRAKSLGE FIKELARDAE AVNEKAIKLN ETLGTRDEAF ERNLEGLQKE IDQMIKELRR KNLETQKEIA EDELVAAEAL LKKVKKLFGE SRGENEEMEK DLREKLADYK NKVDDAWDLL REATDKIREA NRLFAVNQKN MTALEKKKEA VESGKRQIEN TLKEGNDILD EANRLADEIN SIIDYVEDIQ TKLPPMSEEL NDKIDDLSQE IKDRKLAEKV SQAESHAAQL NDSSAVLDGI LDEAKNISFN ATAAFKAYSN IKDYIDEAEK VAKEAKDLAH EATKLATGPR GLLKEDAKGC LQKSFRILNE AKKLANDVKE NEDHLNGLKT RIENADARNG DLLRTLNDTL GKLSAIPNDT AAKLQAVKDK ARQANDTAKD VLAQITELHQ NLDGLKKNYN KLADSVAKTN AVVKDPSKNN AVADADATVK NLEQEADRLI DKLKPIKELE DNLKKNISEI KELINQARKQ ANSIKVSVSS GGDCIRTYKP EIKKGSYNNI VVNVKTAVAD NLLFYLGSAK FIDFLAIEMR KGKVSFLWDV GSGVGRVEYP DLTIDDSYWY RIVASRTGRN GTISVRALDG PKASIVPSTH HSTSPPGYTI LDVDANAMLF VGGLTGKLKK ADAVRVITFT GCMGETYFDN KPIGLWNFRE KEGDCKGCTV SPQVEDSEGT IQFDGEGYAL VSRPIRWYPN ISTVMFKFRT FSSSALLMYL ATRDLRDFMS VELTDGHIKV SYDLGSGMAS VVSNQNHNDG KWKSFTLSRI QKQANISIVD IDTNQEENIA TSSSGNNFGL DLKADDKIYF GGLPTLRNLR PEVNLKKYSG CLKDIEISRT PYNILSSPDY VGVTKGCSLE NVYTVSFPKP GFVELSPVPI DVGTEINLSF STKNESGIIL LGSGGTPAPP RRKRRQTGQA YYAILLNRGR LEVHLSTGAR TMRKIVIRPE PNLFHDGREH SVHVERTRGI FTVQVDENRR YMQNLTVEQP IEVKKLFVGG APPEFQPSPL RNIPPFEGCI WNLVINSVPM DFARPVSFKN ADIGRCAHQK LREDEDGAAP AEIVIQPEPV PTPAFPTPTP VLTHGPCAAE SEPALLIGSK QFGLSRNSHI AIAFDDTKVK NRLTIELEVR TEAESGLLFY MARINHADFA TVQLRNGLPY FSYDLGSGDT HTMIPTKIND GQWHKIKIMR SKQEGILYVD GASNRTISPK KADILDVVGM LYVGGLPINY TTRRIGPVTY SIDGCVRNLH MAEAPADLEQ PTSSFHVGTC FANAQRGTYF DGTGFAKAVG GFKVGLDLLV EFEFRTTTTT GVLLGISSQK MDGMGIEMID EKLMFHVDNG AGRFTAVYDA GVPGHLCDGQ WHKVTANKIK HRIELTVDGN QVEAQSPNPA STSADTNDPV FVGGFPDDLK QFGLTTSIPF RGCIRSLKLT KGTGKPLEVN FAKALELRGV QPVSCPAN //