ID   A0A087WY62_HUMAN        Unreviewed;      1448 AA.
AC   A0A087WY62;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 3.
DT   16-JAN-2019, entry version 35.
DE   SubName: Full=Neuroblastoma breakpoint family member 26 {ECO:0000313|Ensembl:ENSP00000481542};
GN   Name=NBPF26 {ECO:0000313|Ensembl:ENSP00000481542};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000481542, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000481542, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000481542}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC247039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC253572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EPD; A0A087WY62; -.
DR   jPOST; A0A087WY62; -.
DR   PaxDb; A0A087WY62; -.
DR   PeptideAtlas; A0A087WY62; -.
DR   Ensembl; ENST00000620612; ENSP00000481542; ENSG00000273136.
DR   UCSC; uc057jwt.1; human.
DR   EuPathDB; HostDB:ENSG00000273136.5; -.
DR   HGNC; HGNC:49571; NBPF26.
DR   GeneTree; ENSGT00420000029746; -.
DR   ChiTaRS; NBPF26; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000273136; Expressed in 87 organ(s), highest expression level in lower esophagus.
DR   ExpressionAtlas; A0A087WY62; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR010630; Olduvai_dom.
DR   Pfam; PF00008; EGF; 2.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF06758; Olduvai; 10.
DR   SMART; SM01148; DUF1220; 10.
DR   SMART; SM00181; EGF; 6.
DR   SMART; SM00179; EGF_CA; 4.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 5.
DR   PROSITE; PS01186; EGF_2; 5.
DR   PROSITE; PS50026; EGF_3; 6.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS51316; NBPF; 10.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26   1448       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008198997.
FT   DOMAIN       24     63       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN       64    102       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      105    143       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      144    180       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      182    219       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      221    258       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      427    521       NBPF. {ECO:0000259|PROSITE:PS51316}.
FT   DOMAIN      698    790       NBPF. {ECO:0000259|PROSITE:PS51316}.
FT   DOMAIN      791    862       NBPF. {ECO:0000259|PROSITE:PS51316}.
FT   DOMAIN      863    954       NBPF. {ECO:0000259|PROSITE:PS51316}.
FT   DOMAIN      957   1012       NBPF. {ECO:0000259|PROSITE:PS51316}.
FT   DOMAIN     1013   1105       NBPF. {ECO:0000259|PROSITE:PS51316}.
FT   DOMAIN     1106   1198       NBPF. {ECO:0000259|PROSITE:PS51316}.
FT   DOMAIN     1201   1256       NBPF. {ECO:0000259|PROSITE:PS51316}.
FT   DOMAIN     1257   1349       NBPF. {ECO:0000259|PROSITE:PS51316}.
FT   DOMAIN     1350   1448       NBPF. {ECO:0000259|PROSITE:PS51316}.
FT   COILED      337    381       {ECO:0000256|SAM:Coils}.
FT   COILED      554    574       {ECO:0000256|SAM:Coils}.
FT   COILED      601    652       {ECO:0000256|SAM:Coils}.
FT   DISULFID     53     62       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID     73     90       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID     92    101       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    133    142       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    170    179       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    209    218       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   1448 AA;  164476 MW;  5C94E3B00A38EF4F CRC64;
     MPALRPALLW ALLALWLCWA APAHALQCRD GYEPCVNKGM CVTYHSGTGY CKCPEGFLGE
     YCQHRDPCEK NRCQNGGTCV AQAMLGKATC RCASGFTGED CQYSTPHPCF VSRPCLNGGT
     CHMLSRDTYE CTCQVGFTGK ECQWTDACLS HLCANGSTCT TVANQFSCKC LTGFTGQKCE
     TDVNECDIPG HCQHGGTCLN LPGSYQCQCL QGFTGQYCDR LYVPCAHSPC VNGGTCRQTG
     DFTFECNCLP VPDSTSSATN VSMVVSAGHW SSEKAEMNIL EINETLRPQL PENKQQLRNL
     KEKCFLTQLA GFLANRQKKY KYEECKDLIK FMLRNERQFK EEKLAEQLKQ AEELRQYKVL
     VHSQERELTQ LKEKLREGRD ASRSLNEHLQ ALLTPDEPDK SQGQDLQEQL AEGCRLAQHL
     VQKLSPENDE DEDEDVQVEE DEKVLESSAP REVQKTEESK VPEDSLEECA ITCSNSHGPC
     DSNQPHKNIK ITFEEDEVNS TLVVDRESSH DECQDALNIL PVPGPTSSAT NVSMVVSAGP
     LSGEKAAINI LEINEKLRPQ LAEKKQQFRN LKEKCFLTQL AGFLANQQNK YKYEECKDLI
     KSMLRNERQF KEEKLAEQLK QAEELRQYKV LVHAQERELT QLREKLREGR DASRSLNEHL
     QALLTPDEPD KSQGQDLQEQ LAEGCRLAQH LVQKLSPEND NDDDEDVQVE VAEKVQKSSA
     PREMQKAEEK EVPEDSLEEC AITCSNSHGP YDCNQPHRKT KITFEEDKVD STLIGSSSHV
     EWEDAVHIIP ENESDDEEEE EKGPVSPRNL QESEEEEVPQ ESWDEGYSTL SIPPEMLASY
     KSYSSTFHSL EEQQVCMAVD IGRHRWDQVK KEDHEATGPR LSRELLDEKG PEVLQDSLDR
     CYSTPSGCLE LTDSCQPYRS AFYVLEQQRV GLAVDMDEIE KYQEVEEDQD PSCPRLSREL
     LDEKEPEVLQ DSLGRCYSTP SGYLELPDLG QPYSSAVYSL EEQYLGLALD VDRIKKDQEE
     EEDQGPPCPR LSRELLEVVE PEVLQDSLDR CYSTPSSCLE QPDSCQPYGS SFYALEEKHV
     GFSLDVGEIE KKGKGKKRRG RRSKKERRRG RKEGEEDQNP PCPRLSRELL DEKGPEVLQD
     SLDRCYSTPS GCLELTDSCQ PYRSAFYILE QQRVGLAVDM DEIEKYQEVE EDQDPSCPRL
     SRELLDEKEP EVLQDSLGRC YSTPSGYLEL PDLGQPYSSA VYSLEEQYLG LALDVDRIKK
     DQEEEEDQGP PCPRLSRELL EVVEPEVLQD SLDRCYSTPS SCLEQPDSCQ PYGSSFYALE
     EKHVGFSLDV GEIEKKGKGK KRRGRRSKKE RRRGRKEGEE DQNPPCPRLN SMLMEVEEPE
     VLQDSLDICY STPSMYFELP DSFQHYRSVF YSFEEEHISF ALYVDNRFFT LTVTSLHLVF
     QMGVIFPQ
//