ID   A0A087WY08_HUMAN        Unreviewed;      1657 AA.
AC   A0A087WY08;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 27.
DE   SubName: Full=Thrombospondin type-1 domain-containing protein 7A {ECO:0000313|Ensembl:ENSP00000481440};
GN   Name=THSD7A {ECO:0000313|Ensembl:ENSP00000481440};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000481440, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000481440, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000481440}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC004141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC004160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC004614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC073109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WY08; -.
DR   PeptideAtlas; A0A087WY08; -.
DR   Ensembl; ENST00000617773; ENSP00000481440; ENSG00000005108.
DR   UCSC; uc064bol.1; human.
DR   EuPathDB; HostDB:ENSG00000005108.15; -.
DR   HGNC; HGNC:22207; THSD7A.
DR   OpenTargets; ENSG00000005108; -.
DR   eggNOG; ENOG410INDB; Eukaryota.
DR   eggNOG; ENOG410XR0P; LUCA.
DR   GeneTree; ENSGT00940000155427; -.
DR   ChiTaRS; THSD7A; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000005108; Expressed in 198 organ(s), highest expression level in chorionic villus.
DR   ExpressionAtlas; A0A087WY08; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.100.10; -; 11.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF00090; TSP_1; 11.
DR   SMART; SM00209; TSP1; 16.
DR   SUPFAM; SSF82895; SSF82895; 13.
DR   PROSITE; PS50092; TSP1; 11.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A087WY08,
KW   ECO:0000213|MaxQB:A0A087WY08, ECO:0000213|PeptideAtlas:A0A087WY08};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     47       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        48   1657       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832061.
FT   TRANSMEM   1607   1630       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   1657 AA;  185440 MW;  1728DFB50204F517 CRC64;
     MGLQARRWAS GSRGAAGPRR GVLQLLPLPL PLPLLLLLLL RPGAGRAAAQ GEAEAPTLYL
     WKTGPWGRCM GDECGPGGIQ TRAVWCAHVE GWTTLHTNCK QAERPNNQQN CFKVCDWHKE
     LYDWRLGPWN QCQPVISKSL EKPLECIKGE EGIQVREIAC IQKDKDIPAE DIICEYFEPK
     PLLEQACLIP CQQDCIVSEF SAWSECSKTC GSGLQHRTRH VVAPPQFGGS GCPNLTEFQV
     CQSSPCEAEE LRYSLHVGPW STCSMPHSRQ VRQARRRGKN KEREKDRSKG VKDPEARELI
     KKKRNRNRQN RQENKYWDIQ IGYQTREVMC INKTGKAADL SFCQQEKLPM TFQSCVITKE
     CQVSEWSEWS PCSKTCHDMV SPAGTRVRTR TIRQFPIGSE KECPEFEEKE PCLSQGDGVV
     PCATYGWRTT EWTECRVDPL LSQQDKRRGN QTALCGGGIQ TREVYCVQAN ENLLSQLSTH
     KNKEASKPMD LKLCTGPIPN TTQLCHIPCP TECEVSPWSA WGPCTYENCN DQQGKKGFKL
     RKRRITNEPT GGSGVTGNCP HLLEAIPCEE PACYDWKAVR LGNCEPDNGK ECGPGTQVQE
     VVCINSDGEE VDRQLCRDAI FPIPVACDAP CPKDCVLSTW STWSSCSHTC SGKTTEGKQI
     RARSILAYAG EEGGIRCPNS SALQEVRSCN EHPCTVYHWQ TGPWGQCIED TSVSSFNTTT
     TWNGEASCSV GMQTRKVICV RVNVGQVGPK KCPESLRPET VRPCLLPCKK DCIVTPYSDW
     TSCPSSCKEG DSSIRKQSRH RVIIQLPANG GRDCTDPLYE EKACEAPQAC QSYRWKTHKW
     RRCQLVPWSV QQDSPGAQEG CGPGRQARAI TCRKQDGGQA GIHECLQYAG PVPALTQACQ
     IPCQDDCQLT SWSKFSSCNG DCGAVRTRKR TLVGKSKKKE KCKNSHLYPL IETQYCPCDK
     YNAQPVGNWS DCILPEGKVE VLLGMKVQGD IKECGQGYRY QAMACYDQNG RLVETSRCNS
     HGYIEEACII PCPSDCKLSE WSNWSRCSKS CGSGVKVRSK WLREKPYNGG RPCPKLDHVN
     QFQVYEVVPC HSDCNQYLWV TEPWSICKVT FVNMRENCGE GVQTRKVRCM QNTADGPSEH
     VEDYLCDPEE MPLGSRVCKL PCPEDCVISE WGPWTQCVLP CNQSSFRQRS ADPIRQPADE
     GRSCPNAVEK EPCNLNKNCY HYDYNVTDWS TCQLSEKAVC GNGIKTRMLD CVRSDGKSVD
     LKYCEALGLE KNWQMNTSCM VECPVNCQLS DWSPWSECSQ TCGLTGKMIR RRTVTQPFQG
     DGRPCPSLMD QSKPCPVKPC YRWQYGQWSP CQVQEAQCGE GTRTRNISCV VSDGSADDFS
     KVVDEEFCAD IELIIDGNKN MVLEESCSQP CPGDCYLKDW SSWSLCQLTC VNGEDLGFGG
     IQVRSRPVII QELENQHLCP EQMLETKSCY DGQCYEYKWM ASAWKGSSRT VWCQRSDGIN
     VTGGCLVMSQ PDADRSCNPP CSQPHSYCSE TKTCHCEEGY TEVMSSNSTL EQCTLIPVVV
     LPTMEDKRGD VKTSRAVHPT QPSSNPAGRG RTWFLQPFGP DGRLKTWVYG VAAGAFVLLI
     FIVSMIYLAC KKPKKPQRRQ NNRLKPLTLA YDGDADM
//