ID   A0A087WXP3_HUMAN        Unreviewed;       693 AA.
AC   A0A087WXP3;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   13-FEB-2019, entry version 40.
DE   RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN   Name=ITGB6 {ECO:0000313|Ensembl:ENSP00000481183};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000481183, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000481183, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000481183}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000633};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU000633}.
CC   -!- SIMILARITY: Belongs to the integrin beta chain family.
CC       {ECO:0000256|RuleBase:RU000633}.
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DR   EMBL; AC080166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092153; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001269283.1; NM_001282354.1.
DR   UniGene; Hs.470399; -.
DR   ProteinModelPortal; A0A087WXP3; -.
DR   jPOST; A0A087WXP3; -.
DR   PeptideAtlas; A0A087WXP3; -.
DR   PRIDE; A0A087WXP3; -.
DR   Ensembl; ENST00000620391; ENSP00000481183; ENSG00000115221.
DR   GeneID; 3694; -.
DR   UCSC; uc032ohe.2; human.
DR   CTD; 3694; -.
DR   EuPathDB; HostDB:ENSG00000115221.10; -.
DR   HGNC; HGNC:6161; ITGB6.
DR   OpenTargets; ENSG00000115221; -.
DR   eggNOG; KOG1226; Eukaryota.
DR   eggNOG; ENOG410XP60; LUCA.
DR   GeneTree; ENSGT00940000153782; -.
DR   OrthoDB; 473040at2759; -.
DR   ChiTaRS; ITGB6; human.
DR   GenomeRNAi; 3694; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000115221; Expressed in 152 organ(s), highest expression level in visceral pleura.
DR   ExpressionAtlas; A0A087WXP3; baseline and differential.
DR   GO; GO:0030054; C:cell junction; IDA:HPA.
DR   GO; GO:0005813; C:centrosome; IDA:HPA.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005178; F:integrin binding; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR013111; EGF_extracell.
DR   InterPro; IPR040622; I-EGF_1.
DR   InterPro; IPR015812; Integrin_bsu.
DR   InterPro; IPR015436; Integrin_bsu-6.
DR   InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR   InterPro; IPR012896; Integrin_bsu_tail.
DR   InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR   InterPro; IPR002369; Integrin_bsu_VWA.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10082; PTHR10082; 1.
DR   PANTHER; PTHR10082:SF11; PTHR10082:SF11; 1.
DR   Pfam; PF07974; EGF_2; 2.
DR   Pfam; PF18372; I-EGF_1; 1.
DR   Pfam; PF08725; Integrin_b_cyt; 1.
DR   Pfam; PF07965; Integrin_B_tail; 1.
DR   Pfam; PF00362; Integrin_beta; 1.
DR   PRINTS; PR01186; INTEGRINB.
DR   SMART; SM00187; INB; 1.
DR   SMART; SM01241; Integrin_b_cyt; 1.
DR   SMART; SM01242; Integrin_B_tail; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   SUPFAM; SSF69179; SSF69179; 1.
DR   SUPFAM; SSF69687; SSF69687; 1.
DR   PROSITE; PS00243; INTEGRIN_BETA; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion {ECO:0000256|RuleBase:RU000633};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Integrin {ECO:0000256|RuleBase:RU000633,
KW   ECO:0000256|SAAS:SAAS00895071};
KW   Membrane {ECO:0000256|SAAS:SAAS00895947, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A087WXP3,
KW   ECO:0000213|MaxQB:A0A087WXP3, ECO:0000213|PeptideAtlas:A0A087WXP3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00895947,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00895947,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    693       Integrin beta. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832044.
FT   TRANSMEM    615    639       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        7    359       INB. {ECO:0000259|SMART:SM00187}.
FT   DOMAIN      529    612       Integrin_B_tail.
FT                                {ECO:0000259|SMART:SM01242}.
FT   DOMAIN      636    682       Integrin_b_cyt.
FT                                {ECO:0000259|SMART:SM01241}.
SQ   SEQUENCE   693 AA;  75849 MW;  F04FC7553E9228C7 CRC64;
     MGIELLCLFF LFLGRNDHVQ GGAQTLQVHV RQTEDYPVDL YYLMDLSASM DDDLNTIKEL
     GSRLSKEMSK LTSNFRLGFG SFVEKPVSPF VKTTPEEIAN PCSSIPYFCL PTFGFKHILP
     LTNDAERFNE IVKNQKISAN IDTPEGGFDA IMQAAVCKEK IGWRNDSLHL LVFVSDADSH
     FGMDSKLAGI VIPNDGLCHL DSKNEYSMST VLEYPTIGQL IDKLVQNNVL LIFAVTQEQV
     HLYENYAKLI PGATVGLLQK DSGNILQLII SAYEELRSEV ELEVLGDTEG LNLSFTAICN
     NGTLFQHQKK CSHMKVGDTA SFSVTVNIPH CERRSRHIII KPVGLGDALE LLVSPECNCD
     CQKEVEVNSS KCHHGNGSFQ CGVCACHPGH MGPRCECGED MLSTDSCKEA PDHPSCSGRG
     DCYCGQCICH LSPYGNIYGP YCQCDNFSCV RHKGLLCGGN GDCDCGECVC RSGWTGEYCN
     CTTSTDSCVS EDGVLCSGRG DCVCGKCVCT NPGASGPTCE RCPTCGDPCN SKRSCIECHL
     SAAGQAREEC VDKCKLAGAT ISEEEDFSKD GSVSCSLQGE NECLITFLIT TDNEGKTIIH
     SINEKDCPKP PNIPMIMLGV SLAILLIGVV LLCIWKLLVS FHDRKEVAKF EAERSKAKWQ
     TGTNPLYRGS TSTFKNVTYK HREKQKVDLS TDC
//