ID   A0A087WXJ5_HUMAN        Unreviewed;       177 AA.
AC   A0A087WXJ5;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   12-SEP-2018, entry version 24.
DE   SubName: Full=Growth hormone variant {ECO:0000313|Ensembl:ENSP00000481086};
GN   Name=GH2 {ECO:0000313|Ensembl:ENSP00000481086};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000481086, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000481086, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000481086}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU003618,
CC       ECO:0000256|SAAS:SAAS00687159}.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000256|RuleBase:RU003618, ECO:0000256|SAAS:SAAS00680088}.
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DR   EMBL; AC040958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WXJ5; -.
DR   PeptideAtlas; A0A087WXJ5; -.
DR   Ensembl; ENST00000622506; ENSP00000481086; ENSG00000136487.
DR   UCSC; uc060iss.1; human.
DR   EuPathDB; HostDB:ENSG00000136487.17; -.
DR   HGNC; HGNC:4262; GH2.
DR   OpenTargets; ENSG00000136487; -.
DR   GeneTree; ENSGT00730000111012; -.
DR   ChiTaRS; GH2; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000136487; Expressed in 38 organ(s), highest expression level in chorionic villus.
DR   ExpressionAtlas; A0A087WXJ5; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 2.
DR   Pfam; PF00103; Hormone_1; 2.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00835087};
KW   Hormone {ECO:0000256|RuleBase:RU003618};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087WXJ5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00119356};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    177       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832003.
SQ   SEQUENCE   177 AA;  20368 MW;  73079E48DCD4CB41 CRC64;
     MAAGSRTSLL LAFGLLCLSW LQEGSAFPTI PLSRLFDNAM LRARRLYQLA YDTYQEFNLE
     LLRISLLLIQ SWLEPVQLLR SVFANSLVYG ASDSNVYRHL KDLEEGIQTL MWRLEDGSPR
     TGQIFNQSYS KFDTKSHNDD ALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF
//