ID   A0A087WXI5_HUMAN        Unreviewed;       903 AA.
AC   A0A087WXI5;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 37.
DE   SubName: Full=Cadherin-1 {ECO:0000313|Ensembl:ENSP00000481063};
GN   Name=CDH1 {ECO:0000313|Ensembl:ENSP00000481063};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000481063, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000481063, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [4] {ECO:0000313|Ensembl:ENSP00000481063}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC       {ECO:0000256|RuleBase:RU004357}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU003318, ECO:0000256|SAAS:SAAS00544042};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU003318, ECO:0000256|SAAS:SAAS00544042}.
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DR   EMBL; AC099314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WXI5; -.
DR   EPD; A0A087WXI5; -.
DR   jPOST; A0A087WXI5; -.
DR   PeptideAtlas; A0A087WXI5; -.
DR   Ensembl; ENST00000611625; ENSP00000481063; ENSG00000039068.
DR   UCSC; uc059whx.1; human.
DR   EuPathDB; HostDB:ENSG00000039068.18; -.
DR   HGNC; HGNC:1748; CDH1.
DR   OpenTargets; ENSG00000039068; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   eggNOG; ENOG410XQHI; LUCA.
DR   GeneTree; ENSGT00940000157175; -.
DR   OMA; WTIEYND; -.
DR   ChiTaRS; CDH1; human.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000039068; Expressed in 185 organ(s), highest expression level in jejunal mucosa.
DR   ExpressionAtlas; A0A087WXI5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   Gene3D; 4.10.900.10; -; 1.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR000233; Cadherin_cytoplasmic-dom.
DR   InterPro; IPR014868; Cadherin_pro_dom.
DR   InterPro; IPR027397; Catenin_binding_dom_sf.
DR   PANTHER; PTHR24027; PTHR24027; 1.
DR   Pfam; PF00028; Cadherin; 4.
DR   Pfam; PF01049; Cadherin_C; 1.
DR   Pfam; PF08758; Cadherin_pro; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 4.
DR   SMART; SM01055; Cadherin_pro; 1.
DR   SUPFAM; SSF49313; SSF49313; 6.
DR   PROSITE; PS00232; CADHERIN_1; 2.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|RuleBase:RU003318,
KW   ECO:0000256|SAAS:SAAS00020193};
KW   Cell adhesion {ECO:0000256|RuleBase:RU003318,
KW   ECO:0000256|SAAS:SAAS00490458};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00490505};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00490505,
KW   ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01075609};
KW   Proteomics identification {ECO:0000213|EPD:A0A087WXI5,
KW   ECO:0000213|MaxQB:A0A087WXI5, ECO:0000213|PeptideAtlas:A0A087WXI5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    903       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832048.
FT   TRANSMEM    730    752       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       27    116       Cadherin_pro.
FT                                {ECO:0000259|SMART:SM01055}.
FT   DOMAIN      177    260       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      284    373       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      396    506       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      529    614       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   903 AA;  100027 MW;  5F2A0D5359774676 CRC64;
     MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC
     TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG
     HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQIKS
     NKDKEGKVFY SITGQGADTP PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN
     AVEDPMEILI TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI
     AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL QGEGLSTTAT
     AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD ADAPNTPAWE AVYTILNDDG
     GQFVVTTNPV NNDGILKTAK VWYLARCRNW HPHSCSYPCP LGLDFEAKQQ YILHVAVTNV
     VPFEVSLTTS TATVTVDVLD VNEAPIFVPP EKRVEVSEDF GVGQEITSYT AQEPDTFMEQ
     KITYRIWRDT ANWLEINPDT GAISTRAELD REDFEHVKNS TYTALIIATD NGSPVATGTG
     TLLLILSDVN DNAPIPEPRT IFFCERNPKP QVINIIDADL PPNTSPFTAE LTHGASANWT
     IQYNDPTQES IILKPKMALE VGDYKINLKL MDNQNKDQVT TLEVSVCDCE GAAGVCRKAQ
     PVEAGLQIPA ILGILGGILA LLILILLLLL FLRRRAVVKE PLLPPEDDTR DNVYYYDEEG
     GGEEDQDFDL SQLHRGLDAR PEVTRNDVAP TLMSVPRYLP RPANPDEIGN FIDENLKAAD
     TDPTAPPYDS LLVFDYEGSG SEAASLSSLN SSESDKDQDY DYLNEWGNRF KKLADMYGGG
     EDD
//