ID   A0A087WXD1_HUMAN        Unreviewed;       726 AA.
AC   A0A087WXD1;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 36.
DE   RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
GN   Name=SLC9A7 {ECO:0000313|Ensembl:ENSP00000480916};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000480916, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000480916, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA   Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA   Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA   Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA   Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA   Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA   Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA   Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA   Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA   Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA   Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA   Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA   Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA   Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA   Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA   Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA   Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA   Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA   Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA   Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA   Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA   Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA   Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA   Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA   de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA   Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA   Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA   Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA   Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA   Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA   Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA   Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA   Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA   Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA   Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA   Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA   Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA   Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA   Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA   Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA   Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA   Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA   Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA   Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000480916}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1
CC       (CPA1) transporter (TC 2.A.36) family.
CC       {ECO:0000256|RuleBase:RU003722}.
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DR   EMBL; AL022165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL050307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL162583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL512633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001244220.1; NM_001257291.1.
DR   RefSeq; XP_005272738.1; XM_005272681.4.
DR   RefSeq; XP_005272739.1; XM_005272682.4.
DR   RefSeq; XP_011542292.1; XM_011543990.2.
DR   RefSeq; XP_016885394.1; XM_017029905.1.
DR   UniGene; Hs.91389; -.
DR   ProteinModelPortal; A0A087WXD1; -.
DR   SMR; A0A087WXD1; -.
DR   EPD; A0A087WXD1; -.
DR   jPOST; A0A087WXD1; -.
DR   PeptideAtlas; A0A087WXD1; -.
DR   Ensembl; ENST00000616978; ENSP00000480916; ENSG00000065923.
DR   GeneID; 84679; -.
DR   UCSC; uc064ytj.1; human.
DR   CTD; 84679; -.
DR   EuPathDB; HostDB:ENSG00000065923.9; -.
DR   HGNC; HGNC:17123; SLC9A7.
DR   OpenTargets; ENSG00000065923; -.
DR   eggNOG; KOG1965; Eukaryota.
DR   eggNOG; COG0025; LUCA.
DR   GeneTree; ENSGT00940000153460; -.
DR   OMA; SPGHYIQ; -.
DR   OrthoDB; 559433at2759; -.
DR   ChiTaRS; SLC9A7; human.
DR   GenomeRNAi; 84679; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   Bgee; ENSG00000065923; Expressed in 192 organ(s), highest expression level in putamen.
DR   ExpressionAtlas; A0A087WXD1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR002090; Na/H_exchanger_6.
DR   InterPro; IPR004709; NaH_exchanger.
DR   PANTHER; PTHR10110; PTHR10110; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   PRINTS; PR01084; NAHEXCHNGR.
DR   PRINTS; PR01088; NAHEXCHNGR6.
DR   TIGRFAMs; TIGR00840; b_cpa1; 1.
PE   1: Evidence at protein level;
KW   Antiport {ECO:0000256|RuleBase:RU003722,
KW   ECO:0000256|SAAS:SAAS00029193};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ion transport {ECO:0000256|RuleBase:RU003722};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A087WXD1,
KW   ECO:0000213|PeptideAtlas:A0A087WXD1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sodium {ECO:0000256|RuleBase:RU003722};
KW   Sodium transport {ECO:0000256|RuleBase:RU003722};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003722,
KW   ECO:0000256|SAAS:SAAS00029193}.
FT   SIGNAL        1     38       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        39    726       Sodium/hydrogen exchanger.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832041.
FT   TRANSMEM     72     91       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    103    120       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    182    199       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    211    233       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    253    271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    283    305       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    325    351       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    363    396       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    416    436       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    443    462       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    511    536       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       78    535       Na_H_Exchanger.
FT                                {ECO:0000259|Pfam:PF00999}.
SQ   SEQUENCE   726 AA;  80216 MW;  700C1AB4989B221C CRC64;
     MEPGDAARPG SGRATGAPPP RLLLLPLLLG WGLRVAAAAS ASSSGAAAED SSAMEELATE
     KEAEESHRQD SVSLLTFILL LTLTILTIWL FKHRRVRFLH ETGLAMIYGL IVGVILRYGT
     PATSGRDKSL SCTQEDRAFS TLLVNVSGKF FEYTLKGEIS PGKINSVEQN DMLRKVTFDP
     EVFFNILLPP IIFHAGYSLK KRHFFRNLGS ILAYAFLGTA VSCFIIGNLM YGVVKLMKIM
     GQLSDKFYYT DCLFFGAIIS ATDPVTVLAI FNELHADVDL YALLFGESVL NDAVAIVLSS
     SIVAYQPAGL NTHAFDAAAF FKSVGIFLGI FSGSFTMGAV TGVVTALVTK FTKLHCFPLL
     ETALFFLMSW STFLLAEACG FTGVVAVLFC GITQAHYTYN NLSVESRSRT KQLFEVLHFL
     AENFIFSYMG LALFTFQKHV FSPIFIIGAF VAIFLGRAAH IYPLSFFLNL GRRHKIGWNF
     QHMMMFSGLR GAMAFALAIR DTASYARQMM FTTTLLIVFF TVWIIGGGTT PMLSWLNIRV
     GVEEPSEEDQ NEHHWQYFRV GVDPDQDPPP NNDSFQVLQG DGPDSARGNR TKQESAWIFR
     LWYSFDHNYL KPILTHSGPP LTTTLPAWCG LLARCLTSPQ VYDNQEPLRE EDSDFILTEG
     DLTLTYGDST VTANGSSSSH TASTSLEGSR RTKSSSEEVL ERDLGMGDQK VSSRGTRLVF
     PLEDNA
//