ID   A0A087WXC9_HUMAN        Unreviewed;       406 AA.
AC   A0A087WXC9;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 24.
DE   SubName: Full=Mucosal addressin cell adhesion molecule 1 {ECO:0000313|Ensembl:ENSP00000480908};
GN   Name=MADCAM1 {ECO:0000313|Ensembl:ENSP00000480908};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000480908, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000480908, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000480908}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC005775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WXC9; -.
DR   PeptideAtlas; A0A087WXC9; -.
DR   Ensembl; ENST00000613880; ENSP00000480908; ENSG00000099866.
DR   UCSC; uc060qoh.1; human.
DR   EuPathDB; HostDB:ENSG00000099866.14; -.
DR   HGNC; HGNC:6765; MADCAM1.
DR   OpenTargets; ENSG00000099866; -.
DR   GeneTree; ENSGT00510000049549; -.
DR   OMA; QEVACTA; -.
DR   PhylomeDB; A0A087WXC9; -.
DR   ChiTaRS; MADCAM1; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000099866; Expressed in 131 organ(s), highest expression level in vermiform appendix.
DR   ExpressionAtlas; A0A087WXC9; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0098640; F:integrin binding involved in cell-matrix adhesion; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR   GO; GO:2000403; P:positive regulation of lymphocyte migration; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR015169; Adhes-Ig-like.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR037413; MADCAM1.
DR   PANTHER; PTHR14162; PTHR14162; 1.
DR   Pfam; PF09085; Adhes-Ig_like; 1.
DR   ProDom; PD336606; Adhes-Ig-like; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087WXC9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    406       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832028.
FT   DOMAIN       25     94       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   406 AA;  42440 MW;  33F3CD952D499F44 CRC64;
     MDFGLALLLA GLLGLLLGQS LQVKPLQVEP PEPVVAVALG ASRQLTCRLA CADRGASVQW
     RGLDTSLGAV QSDTGRSVLT VRNASLSAAG TRVCVGSCGG RTFQHTVQLL VYAFPDQLTV
     SPAALVPGDP EVACTAHKVT PVDPNALSFS LLVGGQELEG AQALGPEVQE EEEEPQGDED
     VLFRVTERWR LPPLGTPVPP ALYCQATMRL PGLELSHRQA IPALHALSNP EAPAAESPQA
     PSLSTPASSH PTSPEPPDTT SPESPDTTSP ESPDTTSQEP PDTTSPEPPD KTSPEPAPQQ
     GSTHTPRSPG STRTRRPEIS QAGPTQGEVI PTGSSKPAGD QLPAALWTSS AVLGLLLLAL
     PTYHLWKRCR HLAEDDTHPP ASLRLLPQVS AWAGLRGTGQ VGISPS
//