ID   A0A087WXC4_HUMAN        Unreviewed;      1122 AA.
AC   A0A087WXC4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 33.
DE   SubName: Full=Tenascin-N {ECO:0000313|Ensembl:ENSP00000480895};
GN   Name=TNN {ECO:0000313|Ensembl:ENSP00000480895};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000480895, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000480895, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000480895}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; Z99297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Z99715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WXC4; -.
DR   jPOST; A0A087WXC4; -.
DR   PeptideAtlas; A0A087WXC4; -.
DR   Ensembl; ENST00000621086; ENSP00000480895; ENSG00000120332.
DR   UCSC; uc057nmj.1; human.
DR   EuPathDB; HostDB:ENSG00000120332.15; -.
DR   HGNC; HGNC:22942; TNN.
DR   OpenTargets; ENSG00000120332; -.
DR   GeneTree; ENSGT00940000160553; -.
DR   ChiTaRS; TNN; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000120332; Expressed in 74 organ(s), highest expression level in periodontal ligament.
DR   ExpressionAtlas; A0A087WXC4; baseline and differential.
DR   CDD; cd00063; FN3; 7.
DR   CDD; cd00087; FReD; 1.
DR   Gene3D; 2.60.40.10; -; 7.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   InterPro; IPR020837; Fibrinogen_CS.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   Pfam; PF00041; fn3; 7.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00186; FBG; 1.
DR   SMART; SM00060; FN3; 7.
DR   SUPFAM; SSF49265; SSF49265; 4.
DR   SUPFAM; SSF56496; SSF56496; 1.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR   PROSITE; PS50853; FN3; 7.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00730685};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087WXC4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29   1122       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831995.
FT   DOMAIN      264    352       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      353    444       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      445    532       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      533    623       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      624    709       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      710    799       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      800    886       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      884   1101       Fibrinogen C-terminal.
FT                                {ECO:0000259|PROSITE:PS51406}.
FT   COILED      105    125       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1122 AA;  124520 MW;  CEB6311455C997A8 CRC64;
     MSLQEMFRFP MGLLLGSVLL VASAPATLEP PGCSNKEQQV TVSHTYKIDV PKSALVQVDA
     DPQPLSDDGA SLLALGEARE EQNIIFRHNI RLQTPQKDCE LAGSVQDLLA RVKKLEEEMV
     EMKEQCSAQR CCQGVTDLSR HCSGHGTFSL ETCSCHCEEG REGPACERLA CPGACSGHGR
     CVDGRCLCHE PYVGADCGYP ACPENCSGHG ECVRGVCQCH EDFMSEDCSE KRCPGDCSGH
     GFCDTGECYC EEGFTGLDCA QVVTPQGLQL LKNTEDSLLV SWEPSSQVDH YLLSYYPLGK
     ELSGKQIQVP KEQHSYEILG LLPGTKYIVT LRNVKNEVSS SPQHLLATTD LAVLGTAWVT
     DETENSLDVE WENPSTEVDY YKLRYGPMTG QEVAEVTVPK SSDPKSRYDI TGLHPGTEYK
     ITVVPMRGEL EGKPILLNGR TEIDSPTNVV TDRVTEDTAT VSWDPVQAVI DKYVVRYTSA
     DGDTKEMAVH KDESSTVLTG LKPGEAYKVY VWAERGNQGS KKADTNALTD IDSPQNLVTD
     RVTENMATVS WDPVRATIDR YVVRYTSAKD GETREVPVGK EQSSTVLTGL RPGVEYTVHV
     WAQKGAQESK KADTKAQTDI DSPQNLVTDW VTENTATVSW DPVQATIDRY VVHYTSANGE
     TREVPVGKEQ SSTVLTGLRP GMEYTVHVWA QKGNQESKKA DTKAQTEIDG PKNLVTDWVT
     ENMATVSWDP VQATIDKYMV RYTSADGETR EVPVGKEHSS TVLTGLRPGM EYMVHVWAQK
     GAQESKKADT KAQTELDPPR NLRPSAVTQS GGILTWTPPS AQIHGYILTY QFPDGTVKEM
     QLGREDQRFA LQGLEQGATY PVSLVAFKGG RRSRNVSTTL STVGARFPHP SDCSQVQQNS
     NAASGLYTIY LHGDASRPLQ VYCDMETDGG GWIVFQRRNT GQLDFFKRWR SYVEGFGDPM
     KEFWLGLDKL HNLTTGTPAR YEVRVDLQTA NESAYAIYDF FQVASSKERY KLTVGKYRGT
     AGDALTYHNG WKFTTFDRDN DIALSNCALT HHGGWWYKNC HLANPNGRYG ETKHSEGVNW
     EPWKGHEFSI PYVELKIRPH GYSREPVLGR KKRTLRGRLR TF
//