ID A0A087WX80_HUMAN Unreviewed; 3121 AA. AC A0A087WX80; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 16-JAN-2019, entry version 41. DE SubName: Full=Laminin subunit alpha-2 {ECO:0000313|Ensembl:ENSP00000480802}; GN Name=LAMA2 {ECO:0000313|Ensembl:ENSP00000480802}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000480802, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000480802, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000480802} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL356124; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL445439; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL513527; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL583853; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL589927; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL590613; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL669984; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458292; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A087WX80; -. DR jPOST; A0A087WX80; -. DR PeptideAtlas; A0A087WX80; -. DR Ensembl; ENST00000618192; ENSP00000480802; ENSG00000196569. DR UCSC; uc063rgx.1; human. DR EuPathDB; HostDB:ENSG00000196569.11; -. DR HGNC; HGNC:6482; LAMA2. DR OpenTargets; ENSG00000196569; -. DR eggNOG; KOG1836; Eukaryota. DR eggNOG; ENOG410XRDC; LUCA. DR GeneTree; ENSGT00940000155362; -. DR ChiTaRS; LAMA2; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000196569; Expressed in 221 organ(s), highest expression level in esophagus. DR ExpressionAtlas; A0A087WX80; baseline and differential. DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro. DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro. DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro. DR Gene3D; 2.60.120.1490; -; 1. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR009254; Laminin_aI. DR InterPro; IPR010307; Laminin_dom_II. DR InterPro; IPR002049; Laminin_EGF. DR InterPro; IPR001791; Laminin_G. DR InterPro; IPR000034; Laminin_IV. DR InterPro; IPR008211; Laminin_N. DR InterPro; IPR038684; Laminin_N_sf. DR Pfam; PF00052; Laminin_B; 2. DR Pfam; PF00053; Laminin_EGF; 16. DR Pfam; PF00054; Laminin_G_1; 4. DR Pfam; PF02210; Laminin_G_2; 1. DR Pfam; PF06008; Laminin_I; 1. DR Pfam; PF06009; Laminin_II; 1. DR Pfam; PF00055; Laminin_N; 1. DR SMART; SM00181; EGF; 8. DR SMART; SM00180; EGF_Lam; 16. DR SMART; SM00281; LamB; 2. DR SMART; SM00282; LamG; 5. DR SMART; SM00136; LamNT; 1. DR SUPFAM; SSF49899; SSF49899; 5. DR PROSITE; PS01248; EGF_LAM_1; 6. DR PROSITE; PS50027; EGF_LAM_2; 15. DR PROSITE; PS50025; LAM_G_DOMAIN; 5. DR PROSITE; PS51115; LAMININ_IVA; 2. DR PROSITE; PS51117; LAMININ_NTER; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00122, KW ECO:0000256|SAAS:SAAS00814887}; KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460, KW ECO:0000256|SAAS:SAAS00580772}; KW Proteomics identification {ECO:0000213|MaxQB:A0A087WX80, KW ECO:0000213|PeptideAtlas:A0A087WX80}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00966518}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 3121 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001832035. FT DOMAIN 35 286 Laminin N-terminal. FT {ECO:0000259|PROSITE:PS51117}. FT DOMAIN 287 343 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 344 413 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 414 468 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 469 517 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 538 723 Laminin IV type A. FT {ECO:0000259|PROSITE:PS51115}. FT DOMAIN 757 806 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 807 864 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 865 917 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 918 966 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 967 1013 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1014 1059 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1060 1105 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1106 1165 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1180 1379 Laminin IV type A. FT {ECO:0000259|PROSITE:PS51115}. FT DOMAIN 1420 1468 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1469 1526 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1527 1573 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 2144 2327 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 2339 2520 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 2525 2709 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 2762 2933 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 2938 3118 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT COILED 1633 1653 {ECO:0000256|SAM:Coils}. FT COILED 1682 1702 {ECO:0000256|SAM:Coils}. FT COILED 1707 1757 {ECO:0000256|SAM:Coils}. FT COILED 1762 1785 {ECO:0000256|SAM:Coils}. FT COILED 1811 1845 {ECO:0000256|SAM:Coils}. FT COILED 1867 1887 {ECO:0000256|SAM:Coils}. FT COILED 1931 1955 {ECO:0000256|SAM:Coils}. FT COILED 1981 2008 {ECO:0000256|SAM:Coils}. FT COILED 2034 2075 {ECO:0000256|SAM:Coils}. FT COILED 2091 2139 {ECO:0000256|SAM:Coils}. FT DISULFID 309 318 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 381 390 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 414 426 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 444 453 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 488 497 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 776 785 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 835 844 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 889 898 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 901 915 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 918 930 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 920 937 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 939 948 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 967 979 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 987 996 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1032 1041 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1060 1072 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1062 1079 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1081 1090 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1106 1118 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1136 1145 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1439 1448 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1497 1506 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1527 1539 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1529 1546 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1548 1557 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 2682 2709 {ECO:0000256|PROSITE-ProRule:PRU00122}. SQ SEQUENCE 3121 AA; 343751 MW; 5CA93AA9CA241C8C CRC64; MPGAAGVLLL LLLSGGLGGV QAQRPQQQRQ SQAHQQRGLF PAVLNLASNA LITTNATCGE KGPEMYCKLV EHVPGQPVRN PQCRICNQNS SNPNQRHPIT NAIDGKNTWW QSPSIKNGIE YHYVTITLDL QQVFQIAYVI VKAANSPRPG NWILERSLDD VEYKPWQYHA VTDTECLTLY NIYPRTGPPS YAKDDEVICT SFYSKIHPLE NGEIHISLIN GRPSADDPSP ELLEFTSARY IRLRFQRIRT LNADLMMFAH KDPREIDPIV TRRYYYSVKD ISVGGMCICY GHARACPLDP ATNKSRCECE HNTCGDSCDQ CCPGFHQKPW RAGTFLTKTE CEACNCHGKA EECYYDENVA RRNLSLNIRG KYIGGGVCIN CTQNTAGINC ETCTDGFFRP KGVSPNYPRP CQPCHCDPIG SLNEVCVKDE KHARRGLAPG SCHCKTGFGG VSCDRCARGY TGYPDCKACN CSGLGSKNED PCFGPCICKE NVEGGDCSRC KSGFFNLQED NWKGCDECFC SGVSNRCQSS YWTYGKIQDM SGWYLTDLPG RIRVAPQQDD LDSPQQISIS NAEARQALPH SYYWSAPAPY LGNKLPAVGG QLTFTISYDL EEEEEDTERV LQLMIILEGN DLSISTAQDE VYLHPSEEHT NVLLLKEESF TIHGTHFPVR RKEFMTVLAN LKRVLLQITY SFGMDAIFRL SSVNLESAVS YPTDGSIAAA VEVCQCPPGY TGSSCESCWP RHRRVNGTIF GGICEPCQCF GHAESCDDVT GECLNCKDHT GGPYCDKCLP GFYGEPTKGT SEDCQPCACP LNIPSNNFSP TCHLDRSLGL ICDGCPVGYT GPRCERCAEG YFGQPSVPGG SCQPCQCNDN LDFSIPGSCD SLSGSCLICK PGTTGRYCEL CADGYFGDAV DAKNCQPCRC NAGGSFSEVC HSQTGQCECR ANVQGQRCDK CKAGTFGLQS ARGCVPCNCN SFGSKSFDCE ESGQCWCQPG VTGKKCDRCA HGYFNFQEGG CTACECSHLG NNCDPKTGRC ICPPNTIGEK CSKCAPNTWG HSITTGCKAC NCSTVGSLDF QCNVNTGQCN CHPKFSGAKC TECSRGHWNY PRCNLCDCFL PGTDATTCDS ETKKCSCSDQ TGQCTCKVNV EGIHCDRCRP GKFGLDAKNP LGCSSCYCFG TTTQCSEAKG LIRTWVTLKA EQTILPLVDE ALQHTTTKGI VFQHPEIVAH MDLMREDLHL EPFYWKLPEQ FEGKKLMAYG GKLKYAIYFE AREETGFSTY NPQVIIRGGT PTHARIIVRH MAAPLIGQLT RHEIEMTEKE WKYYGDDPRV HRTVTREDFL DILYDIHYIL IKATYGNFMR QSRISEISME VAEQGRGTTM TPPADLIEKC DCPLGYSGLS CEACLPGFYR LRSQPGGRTP GPTLGTCVPC QCNGHSSLCD PETSICQNCQ HHTAGDFCER CALGYYGIVK GLPNDCQQCA CPLISSSNNF SPSCVAEGLD DYRCTACPRG YEGQYCERCA PGYTGSPGNP GGSCQECECD PYGSLPVPCD PVTGFCTCRP GATGRKCDGC KHWHAREGWE CVFCGDECTG LLLGDLARLE QMVMSINLTG PLPAPYKMLY GLENMTQELK HLLSPQRAPE RLIQLAEGNL NTLVTEMNEL LTRATKVTAD GEQTGQDAER TNTRAKSLGE FIKELARDAE AVNEKAIKLN ETLGTRDEAF ERNLEGLQKE IDQMIKELRR KNLETQKEIA EDELVAAEAL LKKVKKLFGE SRGENEEMEK DLREKLADYK NKVDDAWDLL REATDKIREA NRLFAVNQKN MTALEKKKEA VESGKRQIEN TLKEGNDILD EANRLADEIN SIIDYVEDIQ TKLPPMSEEL NDKIDDLSQE IKDRKLAEKV SQAESHAAQL NDSSAVLDGI LDEAKNISFN ATAAFKAYSN IKDYIDEAEK VAKEAKDLAH EATKLATGPR GLLKEDAKGC LQKSFRILNE AKKLANDVKE NEDHLNGLKT RIENADARNG DLLRTLNDTL GKLSAIPNDT AAKLQAVKDK ARQANDTAKD VLAQITELHQ NLDGLKKNYN KLADSVAKTN AVVKDPSKNT VADADATVKN LEQEADRLID KLKPIKELED NLKKNISEIK ELINQARKQA NSIKVSVSSG GDCIRTYKPE IKKGSYNNIV VNVKTAVADN LLFYLGSAKF IDFLAIEMRK GKVSFLWDVG SGVGRVEYPD LTIDDSYWYR IVASRTGRNG TISVRALDGP KASIVPSTHH STSPPGYTIL DVDANAMLFV GGLTGKLKKA DAVRVITFTG CMGETYFDNK PIGLWNFREK EGDCKGCTVS PQVEDSEGTI QFDGEGYALV SRPIRWYPNI STVMFKFRTF SSSALLMYLA TRDLRDFMSV ELTDGHIKVS YDLGSGMASV VSNQNHNDGK WKSFTLSRIQ KQANISIVDI DTNQEENIAT SSSGNNFGLD LKADDKIYFG GLPTLRNLSM KARPEVNLKK YSGCLKDIEI SRTPYNILSS PDYVGVTKGC SLENVYTVSF PKPGFVELSP VPIDVGTEIN LSFSTKNESG IILLGSGGTP APPRRKRRQT GQAYYAILLN RGRLEVHLST GARTMRKIVI RPEPNLFHDG REHSVHVERT RGIFTVQVDE NRRYMQNLTV EQPIEVKKLF VGGAPPEFQP SPLRNIPPFE GCIWNLVINS VPMDFARPVS FKNADIGRCA HQKLREDEDG AAPAEIVIQP EPVPTPAFPT PTPVLTHGPC AAESEPALLI GSKQFGLSRN SHIAIAFDDT KVKNRLTIEL EVRTEAESGL LFYMARINHA DFATVQLRNG LPYFSYDLGS GDTHTMIPTK INDGQWHKIK IMRSKQEGIL YVDGASNRTI SPKKADILDV VGMLYVGGLP INYTTRRIGP VTYSIDGCVR NLHMAEAPAD LEQPTSSFHV GTCFANAQRG TYFDGTGFAK AVGGFKVGLD LLVEFEFRTT TTTGVLLGIS SQKMDGMGIE MIDEKLMFHV DNGAGRFTAV YDAGVPGHLC DGQWHKVTAN KIKHRIELTV DGNQVEAQSP NPASTSADTN DPVFVGGFPD DLKQFGLTTS IPFRGCIRSL KLTKGTGKPL EVNFAKALEL RGVQPVSCPA N //