ID   A0A087WX10_HUMAN        Unreviewed;       404 AA.
AC   A0A087WX10;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   13-FEB-2019, entry version 23.
DE   SubName: Full=Galactocerebrosidase {ECO:0000313|Ensembl:ENSP00000480649};
DE   Flags: Fragment;
GN   Name=GALC {ECO:0000313|Ensembl:ENSP00000480649};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000480649, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000480649, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000480649}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AL136501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL157955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WX10; -.
DR   jPOST; A0A087WX10; -.
DR   PeptideAtlas; A0A087WX10; -.
DR   Ensembl; ENST00000622264; ENSP00000480649; ENSG00000054983.
DR   UCSC; uc059eal.1; human.
DR   EuPathDB; HostDB:ENSG00000054983.16; -.
DR   HGNC; HGNC:4115; GALC.
DR   OpenTargets; ENSG00000054983; -.
DR   eggNOG; ENOG410IITE; Eukaryota.
DR   eggNOG; ENOG410XTIS; LUCA.
DR   GeneTree; ENSGT00390000003303; -.
DR   ChiTaRS; GALC; human.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000054983; Expressed in 238 organ(s), highest expression level in adrenal tissue.
DR   ExpressionAtlas; A0A087WX10; baseline and differential.
DR   GO; GO:0004336; F:galactosylceramidase activity; IEA:InterPro.
DR   GO; GO:0006683; P:galactosylceramide catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001286; Glyco_hydro_59.
DR   InterPro; IPR035394; Glyco_hydro_59_dom.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR15172; PTHR15172; 1.
DR   Pfam; PF02057; Glyco_hydro_59; 1.
DR   Pfam; PF17387; Glyco_hydro_59M; 1.
DR   PRINTS; PR00850; GLHYDRLASE59.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:A0A087WX10,
KW   ECO:0000213|MaxQB:A0A087WX10, ECO:0000213|PeptideAtlas:A0A087WX10};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     39       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        40    404       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832016.
FT   DOMAIN      354    385       Glyco_hydro_59M.
FT                                {ECO:0000259|Pfam:PF17387}.
FT   ACT_SITE    195    195       Proton donor/acceptor.
FT                                {ECO:0000256|PIRSR:PIRSR601286-50}.
FT   ACT_SITE    271    271       Nucleophile.
FT                                {ECO:0000256|PIRSR:PIRSR601286-50}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000480649}.
SQ   SEQUENCE   404 AA;  45328 MW;  AF684E3798ECB210 CRC64;
     XLLSASWQRR AKAMTAAAGS AGRAAVPLLL CALLAPGGAY VLDDSDGLGR EFDGIGAVSG
     GGATSRLLVN YPEPYRSQIL DYLFKPNFGA SLHILKVEIG GDGQTTDGTE PSHMHYALDE
     NYFRGYEWWL MKEAKKRNPN ITLIGLPWSF PGWLGKGFDW PYVNLQLTAY YVVTWIVGAK
     RYHDLDIDYI GIWNERSYNA NYIKILRKML NYQGLQRVKI IASDNLWESI SASMLLDAEL
     FKVVDVIGAH YPGTHSAKDA KLTGKKLWSS EDFSTLNSDM GAGCWGRILN QNYINGYMTS
     TIAWNLVASY YEQLPYGRCG LMTAQEPWSG HYVVESPVWV SAHTTQFTQP GWYYLKTVGH
     LEKGGSYVAL TDGLGNLTII IETMVNFCCC YWINSLLYYW KNKI
//