ID   A0A087WWM1_HUMAN        Unreviewed;      1262 AA.
AC   A0A087WWM1;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 27.
DE   SubName: Full=Mucin-1 {ECO:0000313|Ensembl:ENSP00000480333};
GN   Name=MUC1 {ECO:0000313|Ensembl:ENSP00000480333};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000480333, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000480333, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [3] {ECO:0000313|Ensembl:ENSP00000480333}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC234582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WWM1; -.
DR   SMR; A0A087WWM1; -.
DR   jPOST; A0A087WWM1; -.
DR   PeptideAtlas; A0A087WWM1; -.
DR   Ensembl; ENST00000611571; ENSP00000480333; ENSG00000185499.
DR   UCSC; uc031vap.2; human.
DR   EuPathDB; HostDB:ENSG00000185499.16; -.
DR   HGNC; HGNC:7508; MUC1.
DR   OpenTargets; ENSG00000185499; -.
DR   eggNOG; ENOG410IX6R; Eukaryota.
DR   eggNOG; ENOG410ZQ7Z; LUCA.
DR   GeneTree; ENSGT00710000106874; -.
DR   OMA; EATITMM; -.
DR   ChiTaRS; MUC1; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000185499; Expressed in 199 organ(s), highest expression level in body of stomach.
DR   ExpressionAtlas; A0A087WWM1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.960; -; 1.
DR   InterPro; IPR000082; SEA_dom.
DR   InterPro; IPR036364; SEA_dom_sf.
DR   Pfam; PF01390; SEA; 1.
DR   SMART; SM00200; SEA; 1.
DR   SUPFAM; SSF82671; SSF82671; 1.
DR   PROSITE; PS50024; SEA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A087WWM1,
KW   ECO:0000213|MaxQB:A0A087WWM1, ECO:0000213|PeptideAtlas:A0A087WWM1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24   1262       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831967.
FT   TRANSMEM   1166   1191       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1046   1155       SEA. {ECO:0000259|PROSITE:PS50024}.
SQ   SEQUENCE   1262 AA;  123015 MW;  208A31563A529C3E CRC64;
     MTPGTQSPFF LLLLLTVLTV VTGSGHASST PGGEKETSAT QRSSVPSSTE KNAVSMTSSV
     LSSHSPGSGS STTQGQDVTL APATEPASGS AATWGQDVTS VPVTRPALGS TTPPAHDVTS
     APDNKPAPGS TAPPAHGVTS APDTRPAPGS TAPQAHGVTS APDTRPAPGS TAPPAHGVTS
     APDTRPAPGS TAPPAHGVTS APDTRSAPGS TAPAAHGVTS APDTRSVPGS TAPQAHGVTS
     APDTRPAPGS TAPPAHGVTS APDTRPVPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS
     APDTRPAPGS TAPQAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS
     APDTRPAPGS TAPAAHGVTS APDTRPAPGS TAPQAHGVTS APDTRPAPGS TAPPAHGVTS
     APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPAAHGVTS
     APDTRPAPGS TAPQAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS
     APDTRPAPGS TAPPTHGVTS APDTSPAPGS TAPPAHGVTS APDTRPAPGY TAPAAHGVTS
     APDTRPAPGS TAPQAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS
     APDTRPAPGS TAPPAHGVTS APESRPAPGS TARAAHGVTS APESRPAPGS TAPPAHGVTS
     APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS
     APDTRPAPGS TAPPAHGVTS APDTRPSPPG STAPPAHGVT SAPDTRPAPG STAPPVHGVT
     SAPDTRPAPG STAPPAHGVT SAPDTRPAPG STAPPAHGVT SAPDTRPAPG STAPPAHGVT
     SAPDTRRAPG STPAPGSTAP PAHGVTSAPD TRPAPGSTAP PAHGVTSAPD NRPALGSTAP
     PVHNVTSASG SASGSASTLV HNGTSARATT TPASKSTPFS IPSHHSDTPT TLASHSTKTD
     ASSTHHSTVP PLTSSNHSTS PQLSTGVSFF FLSFHISNLQ FNSSLEDPST DYYQELQRDI
     SEMFLQIYKQ GGFLGLSNIK FRPGSVVVQL TLAFREGTIN VHDVETQFNQ YKTEAASRYN
     LTISDVSVSD VPFPFSAQSG AGVPGWGIAL LVLVCVLVAL AIVYLIALAV CQCRRKNYGQ
     LDIFPARDTY HPMSEYPTYH THGRYVPPSS TDRSPYEKVS AGNGGSSLSY TNPAVAATSA
     NL
//