ID   A0A087WWL4_HUMAN        Unreviewed;        81 AA.
AC   A0A087WWL4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 20.
DE   SubName: Full=Signal peptide peptidase-like 2B {ECO:0000313|Ensembl:ENSP00000480311};
GN   Name=SPPL2B {ECO:0000313|Ensembl:ENSP00000480311};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000480311, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000480311, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000480311}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC004410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WWL4; -.
DR   jPOST; A0A087WWL4; -.
DR   PeptideAtlas; A0A087WWL4; -.
DR   Ensembl; ENST00000586332; ENSP00000480311; ENSG00000005206.
DR   UCSC; uc060rki.1; human.
DR   EuPathDB; HostDB:ENSG00000005206.16; -.
DR   HGNC; HGNC:30627; SPPL2B.
DR   OpenTargets; ENSG00000005206; -.
DR   GeneTree; ENSGT00940000158753; -.
DR   ChiTaRS; SPPL2B; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000005206; Expressed in 172 organ(s), highest expression level in right uterine tube.
DR   ExpressionAtlas; A0A087WWL4; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro.
DR   GO; GO:0031293; P:membrane protein intracellular domain proteolysis; IEA:InterPro.
DR   InterPro; IPR007369; Peptidase_A22B_SPP.
DR   InterPro; IPR033149; SPPL2B.
DR   PANTHER; PTHR12174; PTHR12174; 1.
DR   PANTHER; PTHR12174:SF39; PTHR12174:SF39; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A087WWL4,
KW   ECO:0000213|PeptideAtlas:A0A087WWL4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26     81       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832010.
SQ   SEQUENCE   81 AA;  8354 MW;  16EF8F27B1170E4F CRC64;
     MAAAVAAALA RLLAAFLLLA AQVACEYGMV HVVSQAGGPE GKDYCILYNP QWAHLPHDLS
     KAMPGRGGAA VGTHLVLLSD L
//