ID   A0A087WWD4_HUMAN        Unreviewed;       884 AA.
AC   A0A087WWD4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 35.
DE   SubName: Full=Neural cell adhesion molecule 1 {ECO:0000313|Ensembl:ENSP00000480132};
GN   Name=NCAM1 {ECO:0000313|Ensembl:ENSP00000480132};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000480132, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000480132, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [3] {ECO:0000313|Ensembl:ENSP00000480132}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AP000802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP002853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FP884230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF511120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001229536.1; NM_001242607.1.
DR   UniGene; Hs.503878; -.
DR   UniGene; Hs.711235; -.
DR   UniGene; Hs.733031; -.
DR   ProteinModelPortal; A0A087WWD4; -.
DR   SMR; A0A087WWD4; -.
DR   jPOST; A0A087WWD4; -.
DR   PeptideAtlas; A0A087WWD4; -.
DR   PRIDE; A0A087WWD4; -.
DR   Ensembl; ENST00000619839; ENSP00000480132; ENSG00000149294.
DR   GeneID; 4684; -.
DR   UCSC; uc058hjr.1; human.
DR   CTD; 4684; -.
DR   EuPathDB; HostDB:ENSG00000149294.16; -.
DR   HGNC; HGNC:7656; NCAM1.
DR   OpenTargets; ENSG00000149294; -.
DR   eggNOG; ENOG410IQJI; Eukaryota.
DR   eggNOG; ENOG410XTGB; LUCA.
DR   GeneTree; ENSGT00940000155743; -.
DR   OrthoDB; 129648at2759; -.
DR   ChiTaRS; NCAM1; human.
DR   GenomeRNAi; 4684; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149294; Expressed in 220 organ(s), highest expression level in neocortex.
DR   ExpressionAtlas; A0A087WWD4; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 2.60.40.10; -; 6.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR033019; Ncam1.
DR   InterPro; IPR009138; Neural_cell_adh.
DR   PANTHER; PTHR44059:SF2; PTHR44059:SF2; 2.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF07679; I-set; 3.
DR   PRINTS; PR01838; NCAMFAMILY.
DR   SMART; SM00060; FN3; 2.
DR   SMART; SM00409; IG; 5.
DR   SMART; SM00408; IGc2; 5.
DR   SUPFAM; SSF48726; SSF48726; 5.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   PROSITE; PS50853; FN3; 2.
DR   PROSITE; PS50835; IG_LIKE; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A087WWD4,
KW   ECO:0000213|MaxQB:A0A087WWD4, ECO:0000213|PeptideAtlas:A0A087WWD4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00923712};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    884       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831984.
FT   TRANSMEM    749    772       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       20    111       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      116    189       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      212    301       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      308    439       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      442    527       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      535    634       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      637    732       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
SQ   SEQUENCE   884 AA;  97345 MW;  2CED586CAA41E9F4 CRC64;
     MLQTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK DISWFSPNGE
     KLTPNQQRIS VVWNDDSSST LTIYNANIDD AGIYKCVVTG EDGSESEATV NVKIFQKLMF
     KNAPTPQEFR EGEDAVIVCD VVSSLPPTII WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK
     KTDEGTYRCE GRILARGEIN FKDIQVIVNV PPTIQARQNI VNATANLGQS VTLVCDAEGF
     PEPTMSWTKD GEQIEQEEDD EKYIFSDDSS QLTIKKVDKN DEAEYICIAE NKAGEQDATI
     HLKVFAKPKI TYVENQTAME LEEQVTLTCE ASGDPIPSIT WRTSTRNISS EEKASWTRPE
     KQEVHAPWNW QVGRQKGQAG SAGFPGSHET LDGHMVVRSH ARVSSLTLKS IQYTDAGEYI
     CTASNTIGQD SQSMYLEVQY APKLQGPVAV YTWEGNQVNI TCEVFAYPSA TISWFRDGQL
     LPSSNYSNIK IYNTPSASYL EVTPDSENDF GNYNCTAVNR IGQESLEFIL VQADTPSSPS
     IDQVEPYSST AQVQFDEPEA TGGVPILKYK AEWRAVGEEV WHSKWYDAKE ASMEGIVTIV
     GLKPETTYAV RLAALNGKGL GEISAASEFK TQPVQGEPSA PKLEGQMGED GNSIKVNLIK
     QDDGGSPIRH YLVRYRALSS EWKPEIRLPS GSDHVMLKSL DWNAEYEVYV VAENQQGKSK
     AAHFVFRTSA QPTAIPANGS PTSGLSTGAI VGILIVIFVL LLVVVDITCY FLNKCGLFMC
     IAVNLCGKAG PGAKGKDMEE GKAAFSKDES KEPIVEVRTE EERTPNHDGG KHTEPNETTP
     LTEPEKGPVE AKPECQETET KPAPAEVKTV PNDATQTKEN ESKA
//