ID A0A087WWA5_HUMAN Unreviewed; 1545 AA. AC A0A087WWA5; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 16-JAN-2019, entry version 35. DE SubName: Full=Tenascin-X {ECO:0000313|Ensembl:ENSP00000480067}; GN Name=TNXB {ECO:0000313|Ensembl:ENSP00000480067}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000480067, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000480067, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [3] {ECO:0000313|Ensembl:ENSP00000480067} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL645922; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL662884; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL772248; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A087WWA5; -. DR jPOST; A0A087WWA5; -. DR PeptideAtlas; A0A087WWA5; -. DR Ensembl; ENST00000613214; ENSP00000480067; ENSG00000168477. DR UCSC; uc063nnz.1; human. DR EuPathDB; HostDB:ENSG00000168477.17; -. DR HGNC; HGNC:11976; TNXB. DR OpenTargets; ENSG00000168477; -. DR GeneTree; ENSGT00940000155565; -. DR ChiTaRS; TNXB; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000168477; Expressed in 112 organ(s), highest expression level in left adrenal gland. DR ExpressionAtlas; A0A087WWA5; baseline and differential. DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro. DR GO; GO:0030199; P:collagen fibril organization; IEA:InterPro. DR CDD; cd00063; FN3; 7. DR Gene3D; 2.60.40.10; -; 7. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR013111; EGF_extracell. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR033081; TNX. DR PANTHER; PTHR19143:SF244; PTHR19143:SF244; 11. DR Pfam; PF07974; EGF_2; 2. DR Pfam; PF00041; fn3; 6. DR SMART; SM00181; EGF; 18. DR SMART; SM00060; FN3; 7. DR SUPFAM; SSF49265; SSF49265; 7. DR PROSITE; PS00022; EGF_1; 6. DR PROSITE; PS01186; EGF_2; 6. DR PROSITE; PS50026; EGF_3; 8. DR PROSITE; PS50853; FN3; 7. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Proteomics identification {ECO:0000213|MaxQB:A0A087WWA5, KW ECO:0000213|PeptideAtlas:A0A087WWA5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 1545 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001831993. FT DOMAIN 214 245 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 276 307 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 338 369 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 400 431 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 462 493 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 524 555 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 617 648 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 715 746 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 794 881 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 940 1034 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1046 1138 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1151 1240 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1248 1336 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1350 1439 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1461 1545 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT COILED 100 120 {ECO:0000256|SAM:Coils}. FT DISULFID 218 228 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 235 244 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 280 290 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 297 306 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 342 352 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 359 368 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 404 414 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 421 430 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 466 476 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 483 492 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 528 538 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 545 554 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 621 631 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 638 647 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 719 729 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 736 745 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 1545 AA; 165542 MW; FF59CC15BFE8DB7B CRC64; MMPAQYALTS SLVLLVLLST ARAGPFSSRS NVTLPAPRPP PQPGGHTVGA GVGSPSSQLY EHTVEGGEKQ VVFTHRINLP PSTGCGCPPG TEPPVLASEV QALRVRLEIL EELVKGLKEQ CTGGCCPASA QAGTGQTDVR TLCSLHGVFD LSRCTCSCEP GWGGPTCSDP TDAEIPPSSP PSASGSCPDD CNDQGRCVRG RCVCFPGYTG PSCGWPSCPG DCQGRGRCVQ GVCVCRAGFS GPDCSQRSCP RGCSQRGRCE GGRCVCDPGY TGDDCGMRSC PRGCSQRGRC ENGRCVCNPG YTGEDCGVRS CPRGCSQRGR CKDGRCVCDP GYTGEDCGTR SCPWDCGEGG RCVDGRCVCW PGYTGEDCST RTCPRDCRGR GRCEDGECIC DTGYSGDDCG VRSCPGDCNQ RGRCEDGRCV CWPGYTGTDC GSRACPRDCR GRGRCENGVC VCNAGYSGED CGVRSCPGDC RGRGRCESGR CMCWPGYTGR DCGTRACPGD CRGRGRCVDG RCVCNPGFTG EDCGSRRCPG DCRGHGLCED GVCVCDAGYS GEDCSTRSCP GGCRGRGQCL DGRCVCEDGY SGEDCGVRQC PNDCSQHGVC QDGVCICWEG YVSEDCSIRT CPSNCHGRGR CEEGRCLCDP GYTGPTCATR MCPADCRGRG RCVQGVCLCH VGYGGEDCGQ EEPPASACPG GCGPRELCRA GQCVCVEGFR GPDCAIQTCP GDCRGRGECH DGSCVCKDGY AGEDCGEARV PSSASAYDQR GLAPGQEYQV TVRALRGTSW GLPASKTITT MIDGPQDLRV VAVTPTTLEL GWLRPQAEVD RFVVSYVSAG NQRVRLEVPP EADGTLLTDL MPGVEYVVTV TAERGRAVSY PASVRANTEE REEESPPRPS LSQPPRRPWG NLTAELSRFR GTVQDLERHL RAHGYPLRAN QTYTSVARHI HEYLQRQVLG SSADGALLVS LDGLRGQFER VVLRWRPQPP AEGPGGELTV PGTTRTVSLP DLRPGTTYHV EVHGVRAGQT SKSYAFITTT GPSTTQGAQA PLLQQRPQEL GELRVLGRDE TGRLRVVWTA QPDTFAYFQL RMRVPEGPGA HEEVLPGDVR QALVPPPPPG TPYELSLHGV PPGGKPSDPI IYQGIMDKDE EKPGKSSGPP RLGELTVTDR TSDSLLLRWT VPEGEFDSFV IQYKDRDGQP QVVPVEGPQR SAVITSLDPG RKYKFVLYGF VGKKRHGPLV AEAKILPQSD PSPGTPPHLG NLWVTDPTPD SLHLSWTVPE GQFDTFMVQY RDRDGRPQVV PVEGPERSFV VSSLDPDHKY RFTLFGIANK KRYGPLTADG TTAPERKEEP PRPEFLEQPL LGELTVTGVT PDSLRLSWTV AQGPFDSFMV QYKDAQGQPQ AVPVAGDENE VTVPGLDPDR KYKMNLYGLR GRQRVGPESV VAKTAPQEDV DETPSPTELG TEAPESPEEP LLGELTVTGS SPDSLSLFWT VPQGSFDSFT VQYKDRDGRP RAVRVGGKES EVTVGGLEPG HKYKMHLYGL HEGQRVGPVS AVGVT //