ID   A0A087WW83_HUMAN        Unreviewed;      2368 AA.
AC   A0A087WW83;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 27.
DE   SubName: Full=Probable G-protein-coupled receptor 179 {ECO:0000313|Ensembl:ENSP00000480024};
GN   Name=GPR179 {ECO:0000313|Ensembl:ENSP00000480024};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000480024, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000480024, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000480024}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC244092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WW83; -.
DR   jPOST; A0A087WW83; -.
DR   PeptideAtlas; A0A087WW83; -.
DR   Ensembl; ENST00000621958; ENSP00000480024; ENSG00000277399.
DR   UCSC; uc060elt.1; human.
DR   EuPathDB; HostDB:ENSG00000277399.4; -.
DR   HGNC; HGNC:31371; GPR179.
DR   OpenTargets; ENSG00000277399; -.
DR   eggNOG; KOG4418; Eukaryota.
DR   eggNOG; ENOG410XXEC; LUCA.
DR   GeneTree; ENSGT00940000160776; -.
DR   OMA; NAHTSRM; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000277399; Expressed in 69 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; A0A087WW83; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR032964; GPR179.
DR   PANTHER; PTHR32546:SF7; PTHR32546:SF7; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00500858, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00500858,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00500858,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26   2368       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831997.
FT   TRANSMEM    379    404       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    416    439       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    451    470       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    491    514       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    545    565       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    607    629       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      381    651       G_PROTEIN_RECEP_F3_4.
FT                                {ECO:0000259|PROSITE:PS50259}.
SQ   SEQUENCE   2368 AA;  257432 MW;  3ABE9FD0CECEECC5 CRC64;
     MGTRGAVMPP PMWGLLGCCF VCAWALGGPR PIRSLPPLSS QVKPGSVPMQ VPLEGAEAAL
     AYLYSGDAQQ LSQVNCSERY EARGAGAMPG LPPSLQGAAG TLAQAANFLN MLLQANDIRE
     SSVEEDVEWY QALVRSVAEG DPRVYRALLT FNPPPGASHL QLALQATRTG EETILQDLSG
     NWVQEENPPG DLDTPALKKR VLTNDLGSLG SPKWPQADGY VGDTQQVRLS PPFLECQEGR
     LRPGWLITLS ATFYGLKPDL SPEVSRGQVQ MDVDLQSVDI NQCASGPGWY SNTHLCDLNS
     TQCVPLESQG FVLGRYLCRC RPGFYGASPS GGLEESDFQT TGQFGFPEGR SGRLLQCLPC
     PEGCTSCMDA TPCLVEEAAV LRAAVLACQA CCMLAIFLSM LVSYRCRRNK RIWASGVVLL
     ETVLFGFLLL YFPVFILYFK PSVFRCIALR WVRLLGFAIV YGTIILKLYR VLQLFLSRTA
     QRSALLSSGR LLRHLGLLLL PVLGFLAVWT VGALERGIQH APLVIRGHTP SGRHFYLCHH
     DRWDYIMVVA ELLLLCWGSF LCYATRAVLS AFHEPRYMGI ALHNELLLSA AFHTARFVLV
     PSLHPDWTLL LFFFHTHSTV TTTLALIFIP KFWKLGAPPR EEMVDEVCED ELDLQHSGSY
     LGSSIASAWS EHSLDPGDIR DELKKLYAQL EVHKTKEMAA NNPHLPKKRG SSCQGLGRSF
     MRYLAEFPEA LARQHSRDSG SPGHGSLPGS SRRRLLSSSL QEPEGTPALH KSRSTYDQRR
     EQDPPLLDSL LRRKLAKKAS RTESRESVEG PPALGFRSAS AHNLTVGERL PRARPASLQK
     SLSVASSREK ALLMASQAYL EETYRQAKER EERKKAKAAM ASLVRRPSAR RLERPRGAPL
     SAPPSPAKSS SVDSSHTSGR LHEEARRRLP HPPIRHQVST PILALSGGLG EPRMLSPTST
     LAPALLPALA PTPAPALAPV PVSPQSPNLL TYICPWENAE LPAKQENVPQ EGPSGPERGH
     HSPAPARARL WRALSVAVEK SRAGENEMDA EDAHHQREAN DVDEDRPKIF PKSHSLKAPV
     QQGSMRSLGL AIKALTRSRS TYREKESVEE SPEGQNSGTA GESMGAPSRS PRLGRPKAVS
     KQAALIPSDD KESLQNQQNA HTSRMLQVCQ REGSREQEDR GRRMTQGLGE RKAERAGKTG
     LAMLRQVSRD KNIKQSKETP VGWQELPKAG LQSLGSADHR VAEVCPWEVT ESETRQPDSG
     NKAEICPWET SEGAPESRAL RQDPGDSQKK RGEARGKSEP IDVVPMMRKK PERLVREQEA
     VCPWESADRG GLSPGSAPQD PGRIRDKSEA GDSVEARKVE KPGWEAAGPE AHTPDITKAE
     PCPWEASEGG EDGKPAQEAV KDLPQEKQKT RKATFWKEQK PGGDLESLCP WESTDFRGPS
     AVSIQAPGSS ECSGSLGSGI AEVCLWEAGD APAIQKAEIC PWELDDNVMG QEMLSLGTGR
     ESLQEKEKAS RKGSFGEMGE QTVKAVQKLS QQQESVCPRE STVPGHSSPC LDNSSSKAGS
     QFLCNGGSRA TQVCPQEDLR PEAQEATPAK TEICPWEVNE RTREEWTSAQ VPRGGESQKD
     KEKMPGKSEI EDVTAWEKPE GQIQKQEAVG PWESVDPGSF SPQPRPQDTE RPQTLLQMSG
     SVGSKAADIC PLDVEENLTA GKAEICPWEV GAGAGEERAL GAEAIRKSPN DTGKVSADLG
     PRERAVTAPE KPQKPTPEWE VACPWGSVGP GACSQHPGTL DADGPKAGFQ ELDHMGCRPG
     EVCPWEAQEA ATSEKAKICP WEVSEGTTGK GLDQKAGSES AEQREKALEK GRLTSLGEDV
     SKGMAKLCQQ QETICIWENK DLRESPAQAP KISDLPSSMS SEVAEGHSLE ATEKGDLRQD
     PKTGSFPEHI TQEKAPAADT EEFTTEDGEK TSHELQSVCP WETTAPADSV SHLDRQRPDQ
     PKASSQRLVS TGGRAADVCP WDVPDAGVYK SDSSAKAETC PWEVTERIPV KGVSRQDGKG
     DSQEEKGRAP EKSEPKGVPV QKKPEMADFR QQEAVCPWES QDGKGLSPQP APDASDRSRG
     SSEAAGSVET RVAEVCLWEV VEAPSAKKAE ICPWEAGGGA AEEGEQERES QGQGEMFLQK
     AGPGGTEEHF SKAAAKPREQ EAVCPGEGTG SGGLLPQSGA LDPELKVSPK EAGSMGSRMA
     ELCQWEITDP EGNKIKGTMA DICPGEETGV PSEESGLLAL TATRREFFPT APEKPLCLLV
     HGPLDHFFPE SKIPCPKVSR PASTFTLEGV RELQGPSGLE PRTSLAPEPS LQEAESQSSS
     LTEDSGQVAF EAQYEEFTPP TVYPWDWE
//