ID   A0A087WVT8_HUMAN        Unreviewed;      1628 AA.
AC   A0A087WVT8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 31.
DE   SubName: Full=Kielin/chordin-like protein {ECO:0000313|Ensembl:ENSP00000479679};
GN   Name=KCP {ECO:0000313|Ensembl:ENSP00000479679};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000479679, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000479679, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000479679}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC025594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF495713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016867674.1; XM_017012185.1.
DR   UniGene; Hs.371746; -.
DR   ProteinModelPortal; A0A087WVT8; -.
DR   jPOST; A0A087WVT8; -.
DR   PeptideAtlas; A0A087WVT8; -.
DR   Ensembl; ENST00000610776; ENSP00000479679; ENSG00000135253.
DR   GeneID; 375616; -.
DR   UCSC; uc064hvz.1; human.
DR   CTD; 375616; -.
DR   EuPathDB; HostDB:ENSG00000135253.13; -.
DR   HGNC; HGNC:17585; KCP.
DR   OpenTargets; ENSG00000135253; -.
DR   GeneTree; ENSGT00940000160243; -.
DR   OMA; ACDGCEY; -.
DR   OrthoDB; 1104860at2759; -.
DR   ChiTaRS; KCP; human.
DR   GenomeRNAi; 375616; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000135253; Expressed in 103 organ(s), highest expression level in cortex of kidney.
DR   ExpressionAtlas; A0A087WVT8; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR   GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR014853; Unchr_dom_Cys-rich.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   Pfam; PF00093; VWC; 10.
DR   Pfam; PF00094; VWD; 1.
DR   SMART; SM00832; C8; 1.
DR   SMART; SM00214; VWC; 20.
DR   SMART; SM00215; VWC_out; 8.
DR   SMART; SM00216; VWD; 1.
DR   SUPFAM; SSF57567; SSF57567; 1.
DR   PROSITE; PS01208; VWFC_1; 8.
DR   PROSITE; PS50184; VWFC_2; 17.
DR   PROSITE; PS51233; VWFD; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087WVT8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24   1628       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831945.
FT   DOMAIN      136    189       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      190    249       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      249    308       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      308    366       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      422    481       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      481    540       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      540    598       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      598    657       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      663    721       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      721    778       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      778    837       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      896    955       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      955   1013       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN     1013   1081       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN     1078   1141       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN     1141   1205       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN     1209   1269       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN     1274   1486       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   COILED       60     87       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1628 AA;  173616 MW;  952F08A35C2A7659 CRC64;
     MAGVGAAALS LLLHLGALAL AAGAEGGAVP REPPGQQTTA HSSVLAGNSQ EQWHPLREWL
     GRLEAAVMEL REQNKDLQTR VRQLESCECH PASPQCWGLG RAWPEGARWE PDACTACVCQ
     DGAAHCGPQA HLPHCRGCSQ NGQTYGNGET FSPDACTTCR CLEGTITCNQ KPCPRGPCPE
     PGACCPHCKP GCDYEGQLYE EGVTFLSSSN PCLQCTCLRS RVRCMALKCP PSPCPEPVLR
     PGHCCPTCQG CTEGGSHWEH GQEWTTPGDP CRICRCLEGH IQCRQRECAS LCPYPARPLP
     GTCCPVCDGC FLNGREHRSG EPVGSGDPCS HCRCANGSVQ CEPLPCPPVP CRHPGKIPGQ
     CCPVCDGCEY QGHQYQSQET FRLQERGLCV RCSCQAGEVS CEEQECPVTP CALPASGRQL
     CPACELDGEE FAEGVQWEPD GRPCTACVCQ DGVPKCGAVL CPPAPCQHPT QPPGACCPSC
     DSCTYHSQVY ANGQNFTDAD SPCHACHCQD GTVTCSLVDC PPTTCARPQS GPGQCCPRCP
     DCILEEEVFV DGESFSHPRD PCQECRCQEG HAHCQPRPCP RAPCAHPLPG TCCPNDCSGC
     AFGGKEYPSG ADFPHPSDPC RLCRCLSGNV QCLARRCVPL PCPEPVLLPG ECCPQCPAAP
     APAGCPRPGA AHARHQEYFS PPGDPCRRCL CLDGSVSCQR LPCPPAPCAH PRQGPCCPSC
     DGCLYQGKEF ASGERFPSPT AACHLCLCWE GSVSCEPKAC APALCPFPAR GDCCPDCDGC
     EYLGESYLSN QEFPDPREPC NLCTCLGGFV TCGRRPCEPP GCSHPLIPSG HCCPTCQGCR
     YHGVTTASGE TLPDPLDPTC SLCTCQEGSM RCQKKPCPPA LCPHPSPGPC FCPVCHSCLS
     QGREHQDGEE FEGPAGSCEW CRCQAGQVSC VRLQCPPLPC KLQVTERGSC CPRCRGCLAH
     GEEHPEGSRW VPPDSACSSC VCHEGVVTCA RIQCISSCAQ PRQGPHDCCP QCSDCEHEGR
     KYEPGESFQP GADPCEVCIC EPQPEGPPSL RCHRRQCPSL VGCPPSQLLP PGPQHCCPTC
     AEALSNCSEG LLGSELAPPD PCYTCQCQDL TWLCIHQACP ELSCPLSERH TPPGSCCPVC
     RECVVEAEGR RVADGESWRD PSNACIACTC HRGHVECHLE ECQALSCPHG WAKVPQADSC
     CERCQAPTQS CVHQGREVAS GERWTVDTCT SCSCMAGTVR CQSQRCSPLS CGPDKAPALS
     PGSCCPRCLP RPASCMAFGD PHYRTFDGRL LHFQGSCSYV LAKDCHSGDF SVHVTNDDRG
     RSGVAWTQEV AVLLGDMAVR LLQDGAVTVD GHPVALPFLQ EPLLYVELRG HTVILHAQPG
     LQVLWDGQSQ VEVSVPGSYQ GRTCGLCGNF NGFAQDDLQG PEGLLLPSEA AFGNSWQVSE
     GLWPGRPCSA GREVDPCRAA GYRARREANA RCGVLKSSPF SRCHAVVPPE PFFAACVYDL
     CACGPGSSAD ACLCDALEAY ASHCRQAGVT PTWRGPTLCV VGCPLERGFV FDECGPPCPR
     TCFNQHIPLG ELAAHCVRPC VPGCQCPAGL VEHEAHCIPP EACPQVLLTG DQPLGARPSP
     SREPQETP
//