ID   A0A087WVT3_HUMAN        Unreviewed;       688 AA.
AC   A0A087WVT3;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 38.
DE   SubName: Full=Acyloxyacyl hydrolase {ECO:0000313|Ensembl:ENSP00000479664};
GN   Name=AOAH {ECO:0000313|Ensembl:ENSP00000479664};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000479664, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000479664, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000479664}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC083876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC087069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF454909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF511026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001170977.1; NM_001177506.1.
DR   UniGene; Hs.488007; -.
DR   UniGene; Hs.689297; -.
DR   ProteinModelPortal; A0A087WVT3; -.
DR   jPOST; A0A087WVT3; -.
DR   PeptideAtlas; A0A087WVT3; -.
DR   PRIDE; A0A087WVT3; -.
DR   Ensembl; ENST00000617267; ENSP00000479664; ENSG00000136250.
DR   GeneID; 313; -.
DR   UCSC; uc032zjv.2; human.
DR   CTD; 313; -.
DR   EuPathDB; HostDB:ENSG00000136250.11; -.
DR   HGNC; HGNC:548; AOAH.
DR   OpenTargets; ENSG00000136250; -.
DR   eggNOG; ENOG410IFCC; Eukaryota.
DR   eggNOG; ENOG410XTCS; LUCA.
DR   GeneTree; ENSGT00390000008427; -.
DR   OMA; DPKDGIP; -.
DR   OrthoDB; 692811at2759; -.
DR   ChiTaRS; AOAH; human.
DR   GenomeRNAi; 313; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000136250; Expressed in 176 organ(s), highest expression level in blood.
DR   ExpressionAtlas; A0A087WVT3; baseline and differential.
DR   GO; GO:0050528; F:acyloxyacyl hydrolase activity; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR   GO; GO:0008653; P:lipopolysaccharide metabolic process; IEA:Ensembl.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR   InterPro; IPR039676; AOAH.
DR   InterPro; IPR001087; GDSL.
DR   InterPro; IPR008138; SapB_2.
DR   InterPro; IPR011001; Saposin-like.
DR   InterPro; IPR008139; SaposinB_dom.
DR   PANTHER; PTHR15010; PTHR15010; 1.
DR   Pfam; PF00657; Lipase_GDSL; 1.
DR   Pfam; PF03489; SapB_2; 1.
DR   SMART; SM00741; SapB; 1.
DR   SUPFAM; SSF47862; SSF47862; 1.
DR   PROSITE; PS50015; SAP_B; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:A0A087WVT3,
KW   ECO:0000213|MaxQB:A0A087WVT3, ECO:0000213|PeptideAtlas:A0A087WVT3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    688       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831983.
FT   DOMAIN       37    118       Saposin B-type.
FT                                {ECO:0000259|PROSITE:PS50015}.
SQ   SEQUENCE   688 AA;  77933 MW;  B2FD4DC74D815E39 CRC64;
     MQSPWKILTV APLFLLLSLQ SSASPANDDQ SRPSLSNGHT CVGCVLVVSV IEQLAQVHNS
     TVQASMERLC SYLPEKLFLK TTCYLVIDKF GSDIIKLLSA DMNADVVCHT LEFCKQNTGQ
     PLCHLYPLPK ETWKFTLQKA RQIVKKSPIL KYSRSGSDIC SLPVLAKICQ KIKLAMEQSV
     PFKDVDSDKY SVFPTLRGYH WRGRDCNDSD ESVYPGRRPN NWDVHQDSNC NGIWGVDPKD
     GVPYEKKFCE GSQPRGIILL GDSAGAHFHI SPEWITASQM SLNSFINLPT ALTNELDWPQ
     LSGATGFLDS TVGIKEKSIY LRLWKRNHCN HRDYQNISRN GASSRNLKKF IESLSRNKVL
     DYPAIVIYAM IGNDVCSGKS DPVPAMTTPE KLYSNVMQTL KHLNSHLPNG SHVILYGLPD
     GTFLWDNLHN RYHPLGQLNK DMTYAQLYSF LNCLQVSPCH GWMSSNKTLR TLTSERAEQL
     SNTLKKIAAS EKFTNFNLFY MDFAFHEIIQ EWQKRGGQPW QLIEPVDGFH PNERKSILLK
     GILMTSQTLD NQEWTQLTSW IKGNLTCDSR TREWLCCCWR IISGKRCSSS GPKSWERRIR
     STPRLNRCLE TKAGTEPLRS MHPWGAQGGR GLGKLIPQTL WGLPRHRPKG LFFSSIFAKC
     LSLNEEHIWT TVQCCVLPGS VTLPLFLK
//