ID   A0A087WVP1_HUMAN        Unreviewed;      4590 AA.
AC   A0A087WVP1;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 40.
DE   SubName: Full=Protocadherin Fat 1 {ECO:0000313|Ensembl:ENSP00000479573};
GN   Name=FAT1 {ECO:0000313|Ensembl:ENSP00000479573};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000479573, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000479573, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000213|PubMed:18220336}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18220336; DOI=10.1021/pr0705441;
RA   Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.D., Yates J.R.;
RT   "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for
RT   efficient phosphoproteomic analysis.";
RL   J. Proteome Res. 7:1346-1351(2008).
RN   [3] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [4] {ECO:0000313|Ensembl:ENSP00000479573}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC107050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC110761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WVP1; -.
DR   EPD; A0A087WVP1; -.
DR   jPOST; A0A087WVP1; -.
DR   MaxQB; A0A087WVP1; -.
DR   PeptideAtlas; A0A087WVP1; -.
DR   Ensembl; ENST00000614102; ENSP00000479573; ENSG00000083857.
DR   UCSC; uc063bou.1; human.
DR   EuPathDB; HostDB:ENSG00000083857.13; -.
DR   HGNC; HGNC:3595; FAT1.
DR   OpenTargets; ENSG00000083857; -.
DR   eggNOG; KOG1219; Eukaryota.
DR   eggNOG; ENOG410XPEI; LUCA.
DR   GeneTree; ENSGT00940000157733; -.
DR   OMA; HVFFGGH; -.
DR   PhylomeDB; A0A087WVP1; -.
DR   ChiTaRS; FAT1; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000083857; Expressed in 229 organ(s), highest expression level in epithelium of mammary gland.
DR   ExpressionAtlas; A0A087WVP1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR001791; Laminin_G.
DR   Pfam; PF00028; Cadherin; 29.
DR   Pfam; PF00008; EGF; 2.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 34.
DR   SMART; SM00181; EGF; 5.
DR   SMART; SM00179; EGF_CA; 4.
DR   SMART; SM00282; LamG; 1.
DR   SUPFAM; SSF49313; SSF49313; 33.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00232; CADHERIN_1; 13.
DR   PROSITE; PS00022; EGF_1; 4.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 5.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A087WVP1,
KW   ECO:0000213|MaxQB:A0A087WVP1, ECO:0000213|PeptideAtlas:A0A087WVP1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22   4590       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831979.
FT   TRANSMEM   4184   4204       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     3792   3829       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     3831   4011       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN     4015   4052       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     4054   4090       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     4091   4127       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     4129   4165       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DISULFID   3801   3818       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   4042   4051       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   4080   4089       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   4117   4126       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   4155   4164       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   4590 AA;  506380 MW;  419289F2225FD5D7 CRC64;
     MGRHLALLLL LLLLFQHFGD SDGSQRLEQT PLQFTHLEYN VTVQENSAAK TYVGHPVKMG
     VYITHPAWEV RYKIVSGDSE NLFKAEEYIL GDFCFLRIRT KGGNTAILNR EVKDHYTLIV
     KALEKNTNVE ARTKVRVQVL DTNDLRPLFS PTSYSVSLPE NTAIRTSIAR VSATDADIGT
     NGEFYYSFKD RTDMFAIHPT SGVIVLTGRL DYLETKLYEM EILAADRGMK LYGSSGISSM
     AKLTVHIEQA NECAPVITAV TLSPSELDRD PAYAIVTVDD CDQGANGDIA SLSIVAGDLL
     QQFRTVRSFP GSKEYKVKAI GGIDWDSHPF GYNLTLQAKD KGTPPQFSSV KVIHVTSPQF
     KAGPVKFEKD VYRAEISEFA PPNTPVVMVK AIPAYSHLRY VFKSTPGKAK FSLNYNTGLI
     SILEPVKRQQ AAHFELEVTT SDRKASTKVL VKVLGANSNP PEFTQTAYKA AFDENVPIGT
     TVMSLSAVDP DEGENGYVTY SIANLNHVPF AIDHFTGAVS TSENLDYELM PRVYTLRIRA
     SDWGLPYRRE VEVLATITLN NLNDNTPLFE KINCEGTIPR DLGVGEQITT VSAIDADELQ
     LVQYQIEAGN ELDFFSLNPN SGVLSLKRSL MDGLGAKVSF HSLRITATDG ENFATPLYIN
     ITVAASHKLV NLQCEETGVA KMLAEKLLQA NKLHNQGEVE DIFFDSHSVN AHIPQFRSTL
     PTGIQVKENQ PVGSSVIFMN STDLDTGFNG KLVYAVSGGN EDSCFMIDME TGMLKILSPL
     DRETTDKYTL NITVYDLGIP QKAAWRLLHV VVVDANDNPP EFLQESYFVE VSEDKEVHSE
     IIQVEATDKD LGPNGHVTYS IVTDTDTFSI DSVTGVVNIA RPLDRELQHE HSLKIEARDQ
     AREEPQLFST VVVKVSLEDV NDNPPTFIPP NYRVKVREDL PEGTVIMWLE AHDPDLGQSG
     QVRYSLLDHG EGNFDVDKLS GAVRIVQQLD FEKKQVYNLT VRAKDKGKPV SLSSTCYVEV
     EVVDVNENLH PPVFSSFVEK GTVKEDAPVG SLVMTVSAHD EDARRDGEIR YSIRDGSGVG
     VFKIGEETGV IETSDRLDRE STSHYWLTVF ATDQGVVPLS SFIEIYIEVE DVNDNAPQTS
     EPVYYPEIME NSPKDVSVVQ IEAFDPDSSS NDKLMYKITS GNPQGFFSIH PKTGLITTTS
     RKLDREQQDE HILEVTVTDN GSPPKSTIAR VIVKILDEND NKPQFLQKFY KIRLPEREKP
     DRERNARREP LYHVIATDKD EGPNAEISYS IEDGNEHGKF FIEPKTGVVS SKRFSAAGEY
     DILSIKAVDN GRPQKSSTTR LHIEWISKPK PSLEPISFEE SFFTFTVMES DPVAHMIGVI
     SVEPPGIPLW FDITGGNYDS HFDVDKGTGT IIVAKPLDAE QKSNYNLTVE ATDGTTTILT
     QVFIKVIDTN DHRPQFSTSK YEVVIPEDTA PETEILQISA VDQDEKNKLI YTLQSSRDPL
     SLKKFRLDPA TGSLYTSEKL DHEAVPAHLT VMVRDQDVPV KRNFARIVVN VSDTNDHAPW
     FTASSYKGRV YESAAVGSVV LQVTALDKDK GKNAEVLYSI ESGTFGNIGN SFMIDPVLGS
     IKTAKELDRS NQAEYDLMVK ATDKGSPPMS EITSVRIFVT IADNASPKFT SKEYSVELSE
     TVSIGSFVGM VTAHSQSSVV YEIKDGNTGD AFDINPHSGT IITQKALDFE TLPIYTLIIQ
     GTNMAGLSTN TTVLVHLQDE NDNAPVFMQA EYTGLISESA SINSVVLTDR NVPLVIRAAD
     ADKDSNALLV YHIVEPSVHT YFAIDSSTGA IHTVLSLDYE ETSIFHFTVQ VHDMGTPRLF
     AEYAANVTVH VIDINDCPPV FAKPLYEASL LLPTYKGVKV ITVNATDADS SAFSQLIYSI
     TEGNIGEKFS MDYKTGALTV QNTTQLRSRY ELTVRASDGR FAGLTSVKIN VKESKESHLK
     FTQDVYSAVV KENSTEAETL AVITAIGNPI NEPLFYHILN PDRRFKISRT SGVLSTTGTP
     FDREQQEAFD VVVEVTEEHK PSAVAHVVVK VIVEDQNDNA PVFVNLPYYA VVKVDTEVGH
     VIRYVTAVDR DSGRNGEVHY YLKEHHEHFQ IGPLGEISLK KQFELDTLNK EYLVTVVAKD
     GGNPAFSAEV IVPITVMNKA MPVFEKPFYS AEIAESIQVH SPVVHVQANS PEGLKVFYSI
     TDGDPFSQFT INFNTGVINV IAPLDFEAHP AYKLSIRATD SLTGAHAEVF VDIIVDDIND
     NPPVFAQQSY AVTLSEASVI GTSVVQVRAT DSDSEPNRGI SYQMFGNHSK SHDHFHVDSS
     TGLISLLRTL DYEQSRQHTI FVRAVDGGMP TLSSDVIVTV DVTDLNDNPP LFEQQIYEAR
     ISEHAPHGHF VTCVKAYDAD SSDIDKLQYS ILSGNDHKHF VIDSATGIIT LSNLHRHALK
     PFYSLNLSVS DGVFRSSTQV HVTVIGGNLH SPAFLQNEYE VELAENAPLH TLVMEVKTTD
     GDSGIYGHVT YHIVNDFAKD RFYINERGQI FTLEKLDRET PAEKVISVRL MAKDAGGKVA
     FCTVNVILTD DNDNAPQFRA TKYEVNIGSS AAKGTSVVKV LASDADEGSN ADITYAIEAD
     SESVKENLEI NKLSGVITTK ESLIGLENEF FTFFVRAVDN GSPSKESVVL VYVKILPPEM
     QLPKFSEPFY TFTVSEDVPI GTEIDLIRAE HSGTVLYSLV KGNTPESNRD ESFVIDRQSG
     RLKLEKSLDH ETTKWYQFSI LARCTQDDHE MVASVDVSIQ VKDANDNSPV FESSPYEAFI
     VENLPGGSRV IQIRASDADS GTNGQVMYSL DQSQSVEVIE SFAINMETGW ITTLKELDHE
     KRDNYQIKVV ASDHGEKIQL SSTAIVDVTV TDVNDSPPRF TAEIYKGTVS EDDPQGGVIA
     ILSTTDADSE EINRQVTYFI TGGDPLGQFA VETIQNEWKV YVKKPLDREK RDNYLLTITA
     TDGTFSSKAI VEVKVLDAND NSPVCEKTLY SDTIPEDVLP GKLIMQISAT DADIRSNAEI
     TYTLLGSGAE KFKLNPDTGE LKTSTPLDRE EQAVYHLLVR ATDGGGRFCQ ASIVLTLEDV
     NDNAPEFSAD PYAITVFENT EPGTLLTRVQ ATDADAGLNR KILYSLIDSA DGQFSINELS
     GIIQLEKPLD RELQAVYTLS LKAVDQGLPR RLTATGTVIV SVLDINDNPP VFEYREYGAT
     VSEDILVGTE VLQVYAASRD IEANAEITYS IISGNEHGKF SIDSKTGAVF IIENLDYESS
     HEYYLTVEAT DGGTPSLSDV ATVNVNVTDI NDNTPVFSQD TYTTVISEDA VLEQSVITVM
     ADDADGPSNS HIHYSIIDGN QGSSFTIDPV RGEVKVTKLL DRETISGYTL TVQASDNGSP
     PRVNTTTVNI DVSDVNDNAP VFSRGNYSVI IQENKPVGFS VLQLVVTDED SSHNGPPFFF
     TIVTGNDEKA FEVNPQGVLL TSSAIKRKEK DHYLLQVKVA DNGKPQLSSL TYIDIRVIEE
     SIYPPAILPL EIFITSSGEE YSGGVIGKIH ATDQDVYDTL TYSLDPQMDN LFSVSSTGGK
     LIAHKKLDIG QYLLNVSVTD GKFTTVADIT VHIRQVTQEM LNHTIAIRFA NLTPEEFVGD
     YWRNFQRALR NILGVRRNDI QIVSLQSSEP HPHLDVLLFV EKPGSAQIST KQLLHKINSS
     VTDIEEIIGV RILNVFQKLC AGLDCPWKFC DEKVSVDESV MSTHSTARLS FVTPRHHRAA
     VCLCKEGRCP PVHHGCEDDP CPEGSECVSD PWEEKHTCVC PSGRFGQCPG SSSMTLTGNS
     YVKYRLTENE NKLEMKLTMR LRTYSTHAVV MYARGTDYSI LEIHHGRLQY KFDCGSGPGI
     VSVQSIQVND GQWHAVALEV NGNYARLVLD QVHTASGTAP GTLKTLNLDN YVFFGGHIRQ
     QGTRHGRSPQ VGNGFRGCMD SIYLNGQELP LNSKPRSYAH IEESVDVSPG CFLTATEDCA
     SNPCQNGGVC NPSPAGGYYC KCSALYIGTH CEISVNPCSS KPCLYGGTCV VDNGGFVCQC
     RGLYTGQRCQ LSPYCKDEPC KNGGTCFDSL DGAVCQCDSG FRGERCQSDI DECSGNPCLH
     GALCENTHGS YHCNCSHEYR GRHCEDAAPN QYVSTPWNIG LAEGIGIVVF VAGIFLLVVV
     FVLCRKMISR KKKHQAEPKD KHLGPATAFL QRPYFDSKLN KNIYSDIPPQ VPVRPISYTP
     SIPSDSRNNL DRNSFEGSAI PEHPEFSTFN PESVHGHRKA VAVCSVAPNL PPPPPSNSPS
     DSDSIQKPSW DFDYDTKVVD LDPCLSKKPL EEKPSQPYSA RESLSEVQSL SSFQSESCDD
     NGYHWDTSDW MPSVPLPDIQ EFPNYEVIDE QTPLYSADPN AIDTDYYPGG YDIESDFPPP
     PEDFPAADEL PPLPPEFSNQ FESIHPPRDM PAAGSLGSSS RNRQRFNLNQ YLPNFYPLDM
     SEPQTKGTGE NSTCREPHAP YPPGYQRHFE APAVESMPMS VYASTASCSD VSACCEVESE
     VMMSDYESGD DGHFEEVTIP PLDSQQHTEV
//