ID   A0A087WVC6_HUMAN        Unreviewed;      1342 AA.
AC   A0A087WVC6;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   13-FEB-2019, entry version 39.
DE   SubName: Full=Receptor-type tyrosine-protein phosphatase eta {ECO:0000313|Ensembl:ENSP00000479342};
GN   Name=PTPRJ {ECO:0000313|Ensembl:ENSP00000479342};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000479342, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000479342, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000479342}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein]
CC         + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|SAAS:SAAS01128831};
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DR   EMBL; AC026975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC103828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WVC6; -.
DR   jPOST; A0A087WVC6; -.
DR   PeptideAtlas; A0A087WVC6; -.
DR   Ensembl; ENST00000615445; ENSP00000479342; ENSG00000149177.
DR   UCSC; uc058bip.1; human.
DR   EuPathDB; HostDB:ENSG00000149177.12; -.
DR   HGNC; HGNC:9673; PTPRJ.
DR   OpenTargets; ENSG00000149177; -.
DR   eggNOG; KOG0791; Eukaryota.
DR   eggNOG; COG5599; LUCA.
DR   GeneTree; ENSGT00940000156870; -.
DR   OMA; YENLAPV; -.
DR   ChiTaRS; PTPRJ; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149177; Expressed in 195 organ(s), highest expression level in blood.
DR   ExpressionAtlas; A0A087WVC6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   CDD; cd00063; FN3; 5.
DR   Gene3D; 2.60.40.10; -; 5.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTPase_domain.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; TYR_PHOSPHATASE_dom.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00060; FN3; 8.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF49265; SSF49265; 4.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS50853; FN3; 6.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01031415};
KW   Membrane {ECO:0000256|SAAS:SAAS00897767, ECO:0000256|SAM:Phobius};
KW   Protein phosphatase {ECO:0000256|SAAS:SAAS01031415};
KW   Proteomics identification {ECO:0000213|EPD:A0A087WVC6,
KW   ECO:0000213|MaxQB:A0A087WVC6, ECO:0000213|PeptideAtlas:A0A087WVC6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     35       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        36   1342       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831952.
FT   TRANSMEM    979   1000       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      121    209       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      368    456       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      457    541       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      542    623       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      625    720       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      721    817       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1046   1303       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   DOMAIN     1221   1294       TYR_PHOSPHATASE_2.
FT                                {ECO:0000259|PROSITE:PS50056}.
FT   ACT_SITE   1244   1244       Phosphocysteine intermediate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00160}.
SQ   SEQUENCE   1342 AA;  146558 MW;  19B1C050E9048110 CRC64;
     MKPAAREARL PPRSPGLRWA LPLLLLLLRL GQILCAGGTP SPIPDPSVAT VATGENGITQ
     ISSTAESFHK QNGTGTPQVE TNTSEDGESS GANDSLRTPE QGSNGTDGAS QKTPSSTGPS
     PVFDIKAVSI SPTNVILTWK SNDTAASEYK YVVKHKMENE KTITVVHQPW CNITGLRPAT
     SYVFSITPGI GNETWGDPRV IKVITEPIPV SDLRVALTGV RKAALSWSNG NGTASCRVLL
     ESIGSHEELT QDSRLQVNIS GLKPGVQYNI NPYLLQSNKT KGDPLGTEGG LDASNTERSR
     AGSPTAPVHD ESLVGPVDPS SGQQSRDTEV LLVGLEPGTR YNATVYSQAA NGTEGQPQAI
     EFRTNAIQVF DVTAVNISAT SLTLIWKVSD NESSSNYTYK IHVAGETDSS NLNVSEPRAV
     IPGLRSSTFY NITVCPVLGD IEGTPGFLQV HTPPVPVSDF RVTVVSTTEI GLAWSSHDAE
     SFQMHITQEG AGNSRVEITT NQSIIIGGLF PGTKYCFEIV PKGPNGTEGA SRTVCNRTVP
     SAVFDIHVVY VTTTEMWLDW KSPDGASEYV YHLVIESKHG SNHTSTYDKA ITLQGLIPGT
     LYNITISPEV DHVWGDPNST AQYTRPSNVS NIDVSTNTTA ATLSWQNFDD ASPTYSYCLL
     IEKAGNSSNA TQVVTDIGIT DATVTELIPG SSYTVEIFAQ VGDGIKSLEP GRKSFCTDPA
     SMASFDCEVV PKEPALVLKW TCPPGANAGF ELEVSSGAWN NATHLESCSS ENGTEYRTEV
     TYLNFSTSYN ISITTVSCGK MAAPTRNTCT TGITDPPPPD GSPNITSVSH NSVKVKFSGF
     EASHGPIKAY AVILTTGEAG HPSADVLKYT YEDFKKGASD TYVTYLIRTE EKGRSQSLSE
     VLKYEIDVGN ESTTLGYYNG KLEPLGSYRC LLRACVAGFT NITFHPQNKG LIDGAESYVS
     FSRYSDAVSL PQDPGVICGA VFGCIFGALV IVTVGGFIFW RKKRKDAKNN EVSFSQIKSL
     KRSKLIRVEN FEAYFKKQQA DSNCGFAEEY EDLKLVGISQ PKYAAELAEN RGKNRYNNVL
     PYDISRVKLS VQTHSTDDYI NANYMPGYHS KKDFIATQGP LPNTLKDFWR MVWEKNVYAI
     IMLTKCVEQG RTKCEEYWPS KQAQDYGDIT VAMTSEIVLP EWTIRDFTVK NIQTSESHPL
     RQFHFTSWPD HGVPDTTDLL INFRYLVRDY MKQSPPESPI LVHCSAGVGR TGTFIAIDRL
     IYQIENENTV DVYGIVYDLR MHRPLMVQTE DQYVFLNQCV LDIVRSQKDS KVDLIYQNTT
     AMTIYENLAP VTTFGKTNGY IA
//