ID   A0A087WVA1_HUMAN        Unreviewed;       195 AA.
AC   A0A087WVA1;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 32.
DE   RecName: Full=Selenoprotein T {ECO:0000256|RuleBase:RU362086};
GN   Name=SELENOT {ECO:0000313|Ensembl:ENSP00000479292};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000479292, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000479292, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [3] {ECO:0000313|Ensembl:ENSP00000479292}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the SelWTH family. Selenoprotein T
CC       subfamily. {ECO:0000256|RuleBase:RU362086}.
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DR   EMBL; AC069236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WVA1; -.
DR   EPD; A0A087WVA1; -.
DR   jPOST; A0A087WVA1; -.
DR   Ensembl; ENST00000615547; ENSP00000479292; ENSG00000198843.
DR   UCSC; uc062pap.1; human.
DR   EuPathDB; HostDB:ENSG00000198843.12; -.
DR   HGNC; HGNC:18136; SELENOT.
DR   OpenTargets; ENSG00000198843; -.
DR   eggNOG; KOG3286; Eukaryota.
DR   eggNOG; ENOG4111J49; LUCA.
DR   GeneTree; ENSGT00390000011725; -.
DR   OMA; PEVLFQI; -.
DR   ChiTaRS; SELENOT; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000198843; Expressed in 228 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; A0A087WVA1; baseline and differential.
DR   InterPro; IPR011893; Selenoprotein_Rdx-typ.
DR   InterPro; IPR019389; Selenoprotein_T.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR13544; PTHR13544; 1.
DR   Pfam; PF10262; Rdx; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR02174; CXXU_selWTH; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:A0A087WVA1,
KW   ECO:0000213|MaxQB:A0A087WVA1, ECO:0000213|PeptideAtlas:A0A087WVA1};
KW   Redox-active center {ECO:0000256|RuleBase:RU362086};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Selenocysteine {ECO:0000256|RuleBase:RU362086};
KW   Signal {ECO:0000256|RuleBase:RU362086}.
FT   SIGNAL        1     19       {ECO:0000256|RuleBase:RU362086}.
FT   CHAIN        20    195       Selenoprotein T.
FT                                {ECO:0000256|RuleBase:RU362086}.
FT                                /FTId=PRO_5005106492.
SQ   SEQUENCE   195 AA;  22344 MW;  FC4D2D5474911513 CRC64;
     MRLLLLLLVA ASAMVRSEAS ANLGGVPSKR LKMQYATGPL LKFQIWVSSG YRRVFEEYMR
     VISQRYPDIR IEGENYLPQP IYRHIASFLS VFKLVLIGLI IVGKDPFAFF GMQAPSIWQW
     GQENKVYACM MVFFLSNMIE NQCMSTGAFE ITLNDVPVWS KLESGHLPSM QQLVQILDNE
     MKLNVHMDSI PHHRS
//