ID   A0A087WV21_HUMAN        Unreviewed;       446 AA.
AC   A0A087WV21;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 16.
DE   SubName: Full=Ameloblastin {ECO:0000313|Ensembl:ENSP00000479096};
GN   Name=AMBN {ECO:0000313|Ensembl:ENSP00000479096};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000479096, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000479096, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000479096}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC134919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WV21; -.
DR   jPOST; A0A087WV21; -.
DR   Ensembl; ENST00000613447; ENSP00000479096; ENSG00000178522.
DR   UCSC; uc062xcy.1; human.
DR   EuPathDB; HostDB:ENSG00000178522.14; -.
DR   HGNC; HGNC:452; AMBN.
DR   OpenTargets; ENSG00000178522; -.
DR   eggNOG; ENOG410IMU1; Eukaryota.
DR   eggNOG; ENOG41128SS; LUCA.
DR   GeneTree; ENSGT00390000018227; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000178522; Expressed in 20 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; A0A087WV21; baseline and differential.
DR   GO; GO:0030345; F:structural constituent of tooth enamel; IEA:InterPro.
DR   GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:InterPro.
DR   InterPro; IPR007798; Amelin.
DR   PANTHER; PTHR14115; PTHR14115; 1.
DR   Pfam; PF05111; Amelin; 1.
DR   SMART; SM00817; Amelin; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    446       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831929.
SQ   SEQUENCE   446 AA;  48285 MW;  9CD0F1C2D24A695C CRC64;
     MSASKIPLFK MKDLILILCL LEMSFAVPFF PQQSGTPGMA SLSLETMRQL GSLQRLNTLS
     QYSRYGFGKS FNSLWMHGLL PPHSSLPWMR PREHETQQYE YSLPVHPPPL PSQPSLKPQQ
     PGLKPFLQSA AATTNQATAL KEALQPPIHL GHLPLQEGEL PLVQQQVAPS DKPPKPELRV
     DFADPQGPSL PGMDFPDPQG PSLPGLDFAD PQGSTIFQIA RLISHGPMPQ NKQSPLYPGM
     LYVPFGANQL NAPARLGIMS SEEVAGGRED PMAYGAMFPG FGGMRPGFEG MPHNPAMGGD
     FTLEFDSPVA ATKGPENEEG GAQGSPMPEA NPDNLENPAF LTELEPAPHA GLLALPKDDI
     PGLPRSPSGK MKGLPSVTPA AADPLMTPEL ADVYRTYDAD MTTSVDFQEE ATMDTTMAPN
     SLQTSMPGNK AQEPEMMHDA WHFQEP
//