ID   A0A087WV17_HUMAN        Unreviewed;       286 AA.
AC   A0A087WV17;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 32.
DE   SubName: Full=Osteoclast-associated immunoglobulin-like receptor {ECO:0000313|Ensembl:ENSP00000479089};
GN   Name=OSCAR {ECO:0000313|Ensembl:ENSP00000479089};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000479089, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000479089, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000479089}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000352671}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
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DR   EMBL; AC245052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_996554.2; NM_206818.2.
DR   UniGene; Hs.347655; -.
DR   PRIDE; A0A087WV17; -.
DR   Ensembl; ENST00000359649; ENSP00000352671; ENSG00000170909.
DR   Ensembl; ENST00000611261; ENSP00000479089; ENSG00000170909.
DR   GeneID; 126014; -.
DR   UCSC; uc002qda.5; human.
DR   CTD; 126014; -.
DR   EuPathDB; HostDB:ENSG00000170909.13; -.
DR   HGNC; HGNC:29960; OSCAR.
DR   OpenTargets; ENSG00000170909; -.
DR   eggNOG; ENOG410IHKK; Eukaryota.
DR   eggNOG; ENOG411142H; LUCA.
DR   GeneTree; ENSGT00930000150991; -.
DR   OrthoDB; 1327293at2759; -.
DR   GenomeRNAi; 126014; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000170909; Expressed in 88 organ(s), highest expression level in blood.
DR   ExpressionAtlas; A0A087WV17; baseline and differential.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0038064; F:collagen receptor activity; IEA:Ensembl.
DR   GO; GO:0038094; P:Fc-gamma receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0032623; P:interleukin-2 production; IEA:Ensembl.
DR   GO; GO:0072674; P:multinuclear osteoclast differentiation; IEA:Ensembl.
DR   GO; GO:0045780; P:positive regulation of bone resorption; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   Pfam; PF13895; Ig_2; 1.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A087WV17,
KW   ECO:0000213|PeptideAtlas:A0A087WV17};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    286       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014013272.
FT   DOMAIN       22    104       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   286 AA;  30851 MW;  7AD1FE9C866D65CA CRC64;
     MALVLILQLL TLWPLCHTDI TPSVAIIVPP ASYHPKPWLG AQPATVVTPG VNVTLRCRAP
     QPAWRFGLFK PGEIAPLLFR DVSSELAEFF LEEVTPAQGG SYRCCYRRPD WGPGVWSQPS
     DVLELLVTEE LPRPSLVALP GPVVGPGANV SLRCAGRLRN MSFVLYREGV AAPLQYRHSA
     QPWADFTLLG ARAPGTYSCY YHTPSAPYVL SQRSEVLVIS WEGEGPEARP ASSAPGMQAP
     GPPPSDPGAQ APSLSSFRPR GLVLQPLLPQ TQDSWDPAPP PSDPGV
//