ID   A0A087WUC9_HUMAN        Unreviewed;       211 AA.
AC   A0A087WUC9;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   05-DEC-2018, entry version 19.
DE   SubName: Full=Cytochrome P450 4F8 {ECO:0000313|Ensembl:ENSP00000478555};
DE   Flags: Fragment;
GN   Name=CYP4F8 {ECO:0000313|Ensembl:ENSP00000478555};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000478555, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000478555, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000478555}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC093072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AD000685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WUC9; -.
DR   PeptideAtlas; A0A087WUC9; -.
DR   Ensembl; ENST00000617645; ENSP00000478555; ENSG00000186526.
DR   UCSC; uc060uuj.1; human.
DR   EuPathDB; HostDB:ENSG00000186526.12; -.
DR   HGNC; HGNC:2648; CYP4F8.
DR   OpenTargets; ENSG00000186526; -.
DR   GeneTree; ENSGT00940000155021; -.
DR   ChiTaRS; CYP4F8; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000186526; Expressed in 63 organ(s), highest expression level in seminal vesicle.
DR   ExpressionAtlas; A0A087WUC9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   SUPFAM; SSF48264; SSF48264; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A087WUC9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    211       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831912.
FT   TRANSMEM     31     47       Helical. {ECO:0000256|SAM:Phobius}.
FT   NON_TER     211    211       {ECO:0000313|Ensembl:ENSP00000478555}.
SQ   SEQUENCE   211 AA;  24147 MW;  C7D85AD7545D337D CRC64;
     MGACRMSLLS LSWLGLRPVA ASPWLLLLVV GASWLLARIL AWTYAFYHNG RRLRCFPQPR
     KQNWFLGHLG LVTPTEEGLR VLTQLVATYP QGFVRWLGPI TPIINLCHPD IVRSVINTSD
     AITDKDIVFY KTLKPWLGDG LLLSVGDKWR HHRRLLTPAF HFNILKPYIK IFSKSANIMH
     AKWQRLAMEG STCLDVFEHI SLMTLDSLQK C
//