ID A0A087WUA8_HUMAN Unreviewed; 1681 AA. AC A0A087WUA8; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 05-DEC-2018, entry version 36. DE SubName: Full=Protocadherin-15 {ECO:0000313|Ensembl:ENSP00000478512}; GN Name=PCDH15 {ECO:0000313|Ensembl:ENSP00000478512}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000478512, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000478512, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., RA Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000478512} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC013737; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC016817; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC024073; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC027671; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL353784; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL360214; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL365496; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL391356; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF455239; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A087WUA8; -. DR PeptideAtlas; A0A087WUA8; -. DR Ensembl; ENST00000614895; ENSP00000478512; ENSG00000150275. DR UCSC; uc057thw.1; human. DR EuPathDB; HostDB:ENSG00000150275.17; -. DR HGNC; HGNC:14674; PCDH15. DR OpenTargets; ENSG00000150275; -. DR eggNOG; KOG3594; Eukaryota. DR eggNOG; ENOG410XQHI; LUCA. DR GeneTree; ENSGT00940000156675; -. DR ChiTaRS; PCDH15; human. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000150275; Expressed in 67 organ(s), highest expression level in corpus callosum. DR ExpressionAtlas; A0A087WUA8; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:InterPro. DR GO; GO:0032420; C:stereocilium; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro. DR GO; GO:0048839; P:inner ear development; IEA:InterPro. DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro. DR InterPro; IPR002126; Cadherin-like_dom. DR InterPro; IPR015919; Cadherin-like_sf. DR InterPro; IPR020894; Cadherin_CS. DR InterPro; IPR030718; Protocadherin-15. DR PANTHER; PTHR24028:SF11; PTHR24028:SF11; 4. DR Pfam; PF00028; Cadherin; 8. DR PRINTS; PR00205; CADHERIN. DR SMART; SM00112; CA; 11. DR SUPFAM; SSF49313; SSF49313; 10. DR PROSITE; PS00232; CADHERIN_1; 3. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|SAAS:SAAS00020193}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A087WUA8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00436611}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00616217, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00616217, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 1681 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001831939. FT TRANSMEM 1380 1402 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 69 150 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 179 268 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 309 398 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 431 512 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 536 618 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 643 720 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 744 822 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 846 929 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 953 1039 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 1060 1147 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 1171 1255 CA. {ECO:0000259|SMART:SM00112}. SQ SEQUENCE 1681 AA; 186742 MW; B0849E68BD3A4001 CRC64; MFRQFYLWTC LASGIILGSL FEICLGQYDD DWQYEDCKLA RGGPPATIVA IDEESRNGTI LVDNMLIKGT AGGPDPTIEL SLKDNVDYWV LMDPVKQMLF LNSTGRVLDR DPPMNIHSIV VQVQCINKKV GTIIYHEVRI VVRDRNDNSP TFKHESYYAT VNELTPVGTT IFTGFSGDNG ATDIDDGPNG QIEYVIQYNP DDPTSNDTFE IPLMLTGNIV LRKRLNYEDK TRYFVIIQAN DRAQNLNERR TTTTTLTVDV LDGDDLGPMF LPCVLVPNTR DCRPLTYQAA IPELRTPEEL NPIIVTPPIQ AIDQDRNIQP PSDRPGILYS ILVGTPEDYP RFFHMHPRTA ELSLLEPVNR DFHQKFDLVI KAEQDNGHPL PAFAGLHIEI LDENNQSPYF TMPSYQGYIL ESAPVGATIS DSLNLTSPLR IVALDKDIED TKDPELHLFL NDYTSVFTVT QTGITRYLTL LQPVDREEQQ TYTFSITAFD GVQESEPVIV NIQVMDANDN TPTFPEISYD VYVYTDMRPG DSVIQLTAVD ADEGSNGEIT YEILVGAQGD FIINKTTGLI TIAPGVEMIV GRTYALTVQA ADNAPPAERR NSICTVYIEV LPPNNQSPPR FPQLMYSLEI SEAMRVGAVL LNLQATDREG DSITYAIENG DPQRVFNLSE TTGILTLGKA LDRESTDRYI LIITASDGRP DGTSTATVNI VVTDVNDNAP VFDPYLPRNL SVVEEEANAF VGQVKATDPD AGINGQVHYS LGNFNNLFRI TSNGSIYTAV KLNREVRDYY ELVVVATDGA VHPRHSTLTL AIKVLDIDDN SPVFTNSTYT VLVEENLPAG TTILQIEAKD VDLGANVSYR IRSPEVKHFF ALHPFTGELS LLRSLDYEAF PDQEASITFL VEAFDIYGTM PPGIATVTVI VKDMNDYPPV FSKRIYKGMV APDAVKGTPI TTVYAEDADP PGLPASRVRY RVDDVQFPYP ASIFEVEEDS GRVITRVNLN EEPTTIFKLV VVAFDDGEPV MSSSATVKIL VLHPGEIPRF TQEEYRPPPV SELATKGTMV GVISAAAINQ SIVYSIVSGN EEDTFGINNI TGVIYVNGPL DYETRTSYVL RVQADSLEVV LANLRVPSKS NTAKVYIEIQ DENNHPPVFQ KKFYIGGVSE DARMFTSVLR VKATDKDTGN YSVMAYRLII PPIKEGKEGF VVETYTGLIK TAMLFHNMRR SYFKFQVIAT DDYGKGLSGK ADVLVSVVNQ LDMQVIVSNV PPTLVEKKIE DLTEILDRYV QEQIPGAKVV VESIGARRHG DAFSLEDYTK CDLTVYAIDP QTNRAIDRNE LFKFLDGKLL DINKDFQPYY GEGGRILEIR TPEAVTSIKK RGESLGYTEG ALLALAFIII LCCIPAILVV LVSYRQVFKG RQAECTKTAR IQAALPAAKP AVPAPAPVAA PPPPPPPPPG AHLYEELGDS SMYEMPQYGS RRRLLPPAGQ EEYGEVVGEA EEEYEEEEWA RKRMIKLVVD REYETSSTGE DSAPECQRNR LHHPSIHSNI NGNIYIAQNG SVVRTRRACL TDNLKVASPV RLGGPFKKLD KLAVTHEENV PLNTLSKGPF STEKMNARPT LVTFAPCPVG TDNTAVKPLR NRLKSTVEQE SMIDSKNIKE ALEFHSDHTQ SDDEELWMGP WNNLHIPMTK L //