ID   A0A087WTY2_HUMAN        Unreviewed;       119 AA.
AC   A0A087WTY2;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 21.
DE   SubName: Full=Beta-hexosaminidase subunit alpha {ECO:0000313|Ensembl:ENSP00000478217};
GN   Name=HEXA {ECO:0000313|Ensembl:ENSP00000478217};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000478217, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000478217, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000478217}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC009690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WTY2; -.
DR   jPOST; A0A087WTY2; -.
DR   PeptideAtlas; A0A087WTY2; -.
DR   Ensembl; ENST00000567213; ENSP00000478217; ENSG00000213614.
DR   UCSC; uc059lbr.1; human.
DR   EuPathDB; HostDB:ENSG00000213614.9; -.
DR   HGNC; HGNC:4878; HEXA.
DR   OpenTargets; ENSG00000213614; -.
DR   eggNOG; KOG2499; Eukaryota.
DR   eggNOG; COG3525; LUCA.
DR   GeneTree; ENSGT00390000008107; -.
DR   ChiTaRS; HEXA; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000213614; Expressed in 225 organ(s), highest expression level in tendon of biceps brachii.
DR   ExpressionAtlas; A0A087WTY2; baseline and differential.
DR   Gene3D; 3.30.379.10; -; 1.
DR   InterPro; IPR029018; Hex-like_dom2.
DR   InterPro; IPR029019; HEX_eukaryotic_N.
DR   Pfam; PF14845; Glycohydro_20b2; 1.
DR   SUPFAM; SSF55545; SSF55545; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    119       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831921.
FT   DOMAIN       23     81       Glycohydro_20b2.
FT                                {ECO:0000259|Pfam:PF14845}.
SQ   SEQUENCE   119 AA;  13323 MW;  8FDB43A5B21BEFA7 CRC64;
     MTSSRLWFSL LLAAAFAGRA TALWPWPQNF QTSDQRYVLY PNNFQFQYDV SSAAQPGCSV
     LDEAFQRYRD LLFGSGSWPR PYLTGLSLSF RLECSGVITA YSNLELQDSS SLPASLMSS
//