ID   A0A087WTR7_HUMAN        Unreviewed;       314 AA.
AC   A0A087WTR7;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   05-DEC-2018, entry version 31.
DE   SubName: Full=Cadherin-24 {ECO:0000313|Ensembl:ENSP00000478078};
GN   Name=CDH24 {ECO:0000313|Ensembl:ENSP00000478078};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000478078, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000478078, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000478078}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC       {ECO:0000256|RuleBase:RU004357}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|SAAS:SAAS00555546}; Single-pass type I membrane
CC       protein {ECO:0000256|SAAS:SAAS00555546}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AL132780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WTR7; -.
DR   Ensembl; ENST00000610348; ENSP00000478078; ENSG00000139880.
DR   UCSC; uc058zoh.1; human.
DR   EuPathDB; HostDB:ENSG00000139880.19; -.
DR   HGNC; HGNC:14265; CDH24.
DR   OpenTargets; ENSG00000139880; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   eggNOG; ENOG410XQHI; LUCA.
DR   GeneTree; ENSGT00940000159567; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000139880; Expressed in 132 organ(s), highest expression level in cerebellar hemisphere.
DR   ExpressionAtlas; A0A087WTR7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   Gene3D; 4.10.900.10; -; 1.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR000233; Cadherin_cytoplasmic-dom.
DR   InterPro; IPR027397; Catenin_binding_dom_sf.
DR   PANTHER; PTHR24027; PTHR24027; 2.
DR   Pfam; PF00028; Cadherin; 1.
DR   Pfam; PF01049; Cadherin_C; 1.
DR   SMART; SM00112; CA; 1.
DR   SUPFAM; SSF49313; SSF49313; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|SAAS:SAAS00983763};
KW   Cell adhesion {ECO:0000256|SAAS:SAAS00490458};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00490505};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00490505,
KW   ECO:0000256|SAAS:SAAS00983775, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01075609};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00983775,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00983775,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    314       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831877.
FT   TRANSMEM    136    157       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       67    148       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   314 AA;  33903 MW;  E5EFA5C37D7BC72B CRC64;
     MWGLVRLLLA WLGGWGCMGR LAAPARAWAG SREHPGPALL RTRRSWVWNQ FFVIEEYAGP
     EPVLIGKLHS DVDRGEGRTK YLLTGEGAGT VFVIDEATGN IHVTKSLDRE EKAQYVLLAQ
     AVDRASNRPL EPPSEFIIKI ITCVGALLAL VVLFVALRRQ KQEALMVLEE EDVRENIITY
     DDEGGGEEDT EAFDITALQN PDGAAPPAPG PPARRDVLPR ARVSRQPRPP GPADVAQLLA
     LRLREADEDP GVPPYDSVQV YGYEGRGSSC GSLSSLGSGS EAGGAPGPAE PLDDWGPLFR
     TLAELYGAKE PPAP
//