ID   A0A087WTR6_HUMAN        Unreviewed;      1539 AA.
AC   A0A087WTR6;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 38.
DE   SubName: Full=Protocadherin-15 {ECO:0000313|Ensembl:ENSP00000478076};
GN   Name=PCDH15 {ECO:0000313|Ensembl:ENSP00000478076};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000478076, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000478076, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000478076}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC013737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC024073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC027671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL360214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL365496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL391356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001136242.1; NM_001142770.1.
DR   UniGene; Hs.280209; -.
DR   ProteinModelPortal; A0A087WTR6; -.
DR   SMR; A0A087WTR6; -.
DR   MaxQB; A0A087WTR6; -.
DR   PeptideAtlas; A0A087WTR6; -.
DR   PRIDE; A0A087WTR6; -.
DR   Ensembl; ENST00000617271; ENSP00000478076; ENSG00000150275.
DR   GeneID; 65217; -.
DR   UCSC; uc057tid.1; human.
DR   CTD; 65217; -.
DR   EuPathDB; HostDB:ENSG00000150275.17; -.
DR   HGNC; HGNC:14674; PCDH15.
DR   OpenTargets; ENSG00000150275; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   eggNOG; ENOG410XQHI; LUCA.
DR   GeneTree; ENSGT00940000156675; -.
DR   OrthoDB; 21247at2759; -.
DR   ChiTaRS; PCDH15; human.
DR   GenomeRNAi; 65217; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000150275; Expressed in 67 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; A0A087WTR6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0032420; C:stereocilium; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0048839; P:inner ear development; IEA:InterPro.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR030718; Protocadherin-15.
DR   PANTHER; PTHR24028:SF11; PTHR24028:SF11; 2.
DR   Pfam; PF00028; Cadherin; 8.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 11.
DR   SUPFAM; SSF49313; SSF49313; 10.
DR   PROSITE; PS00232; CADHERIN_1; 3.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087WTR6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27   1539       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831906.
FT   TRANSMEM   1375   1397       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       64    145       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      174    263       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      304    393       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      426    507       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      531    613       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      638    715       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      739    817       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      841    924       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      948   1034       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1055   1142       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1166   1250       CA. {ECO:0000259|SMART:SM00112}.
FT   COILED     1507   1537       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1539 AA;  171260 MW;  5C60650A65443CB8 CRC64;
     MFRQFYLWTC LASGIILGSL FEICLGQYDD DCKLARGGPP ATIVAIDEES RNGTILVDNM
     LIKGTAGGPD PTIELSLKDN VDYWVLMDPV KQMLFLNSTG RVLDRDPPMN IHSIVVQVQC
     INKKVGTIIY HEVRIVVRDR NDNSPTFKHE SYYATVNELT PVGTTIFTGF SGDNGATDID
     DGPNGQIEYV IQYNPDDPTS NDTFEIPLML TGNIVLRKRL NYEDKTRYFV IIQANDRAQN
     LNERRTTTTT LTVDVLDGDD LGPMFLPCVL VPNTRDCRPL TYQAAIPELR TPEELNPIIV
     TPPIQAIDQD RNIQPPSDRP GILYSILVGT PEDYPRFFHM HPRTAELSLL EPVNRDFHQK
     FDLVIKAEQD NGHPLPAFAG LHIEILDENN QSPYFTMPSY QGYILESAPV GATISDSLNL
     TSPLRIVALD KDIEDTKDPE LHLFLNDYTS VFTVTQTGIT RYLTLLQPVD REEQQTYTFS
     ITAFDGVQES EPVIVNIQVM DANDNTPTFP EISYDVYVYT DMRPGDSVIQ LTAVDADEGS
     NGEITYEILV GAQGDFIINK TTGLITIAPG VEMIVGRTYA LTVQAADNAP PAERRNSICT
     VYIEVLPPNN QSPPRFPQLM YSLEISEAMR VGAVLLNLQA TDREGDSITY AIENGDPQRV
     FNLSETTGIL TLGKALDRES TDRYILIITA SDGRPDGTST ATVNIVVTDV NDNAPVFDPY
     LPRNLSVVEE EANAFVGQVK ATDPDAGING QVHYSLGNFN NLFRITSNGS IYTAVKLNRE
     VRDYYELVVV ATDGAVHPRH STLTLAIKVL DIDDNSPVFT NSTYTVLVEE NLPAGTTILQ
     IEAKDVDLGA NVSYRIRSPE VKHFFALHPF TGELSLLRSL DYEAFPDQEA SITFLVEAFD
     IYGTMPPGIA TVTVIVKDMN DYPPVFSKRI YKGMVAPDAV KGTPITTVYA EDADPPGLPA
     SRVRYRVDDV QFPYPASIFE VEEDSGRVIT RVNLNEEPTT IFKLVVVAFD DGEPVMSSSA
     TVKILVLHPG EIPRFTQEEY RPPPVSELAT KGTMVGVISA AAINQSIVYS IVSGNEEDTF
     GINNITGVIY VNGPLDYETR TSYVLRVQAD SLEVVLANLR VPSKSNTAKV YIEIQDENNH
     PPVFQKKFYI GGVSEDARMF TSVLRVKATD KDTGNYSVMA YRLIIPPIKE GKEGFVVETY
     TGLIKTAMLF HNMRRSYFKF QVIATDDYGK GLSGKADVLV SVVNQLDMQV IVSNVPPTLV
     EKKIEDLTEI LDRYVQEQIP GAKVVVESIG ARRHGDAFSL EDYTKCDLTV YAIDPQTNRA
     IDRNELFKFL DGKLLDINKD FQPYYGEGGR ILEIRTPEAV TSIKKRGESL GYTEGALLAL
     AFIIILCCIP AILVVLVSYR QFKVRQAECT KTARIQAALP AAKPAVPAPA PVAAPPPPPP
     PPPGAHLYEE LGDSSMHKNY PWSLELILAR NMDKIITVMS MGMKCLNMGV AVDCYHQLDR
     RNMVRWLVKL RKNMRRKRKS QRKLKNQRLK LESLVRRKK
//