ID   A0A087WTM9_HUMAN        Unreviewed;       244 AA.
AC   A0A087WTM9;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 2.
DT   16-JAN-2019, entry version 25.
DE   SubName: Full=Tumor necrosis factor receptor superfamily member 6 {ECO:0000313|Ensembl:ENSP00000477997};
GN   Name=FAS {ECO:0000313|Ensembl:ENSP00000477997};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000477997, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000477997, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000477997}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR   EMBL; AL157394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; A0A087WTM9; -.
DR   PeptideAtlas; A0A087WTM9; -.
DR   Ensembl; ENST00000612663; ENSP00000477997; ENSG00000026103.
DR   EuPathDB; HostDB:ENSG00000026103.19; -.
DR   HGNC; HGNC:11920; FAS.
DR   OpenTargets; ENSG00000026103; -.
DR   GeneTree; ENSGT00730000111280; -.
DR   ChiTaRS; FAS; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000026103; Expressed in 216 organ(s), highest expression level in right ovary.
DR   ExpressionAtlas; A0A087WTM9; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd10579; TNFRSF6; 1.
DR   InterPro; IPR008063; Fas_rcpt.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR033999; TNFRSF6_N.
DR   PANTHER; PTHR23097:SF114; PTHR23097:SF114; 1.
DR   Pfam; PF00020; TNFR_c6; 2.
DR   PRINTS; PR01680; TNFACTORR6.
DR   SMART; SM00208; TNFR; 3.
DR   PROSITE; PS50050; TNFR_NGFR_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A087WTM9,
KW   ECO:0000213|PeptideAtlas:A0A087WTM9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    244       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008198998.
FT   REPEAT       84    127       TNFR-Cys. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00206}.
FT   DOMAIN       84    127       TNFR-Cys. {ECO:0000259|PROSITE:PS50050}.
FT   REPEAT      128    165       TNFR-Cys. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00206}.
FT   DOMAIN      128    165       TNFR-Cys. {ECO:0000259|PROSITE:PS50050}.
SQ   SEQUENCE   244 AA;  27145 MW;  E55E04625EEBF97B CRC64;
     MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE GLHHDGQFCH
     KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK CRRCRLCDEG HGLEVEINCT
     RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE HGIIKECTLT SNTKCKEEGS RSNLGWLCLL
     LLPIPLIVWV KRKEVQKTCR KHRKENQGSH ESPTLNPMES CSIAQAGVQG CNHGSLQPQS
     PGLK
//