ID   A0A087WTF6_HUMAN        Unreviewed;       848 AA.
AC   A0A087WTF6;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 32.
DE   SubName: Full=Neural cell adhesion molecule 1 {ECO:0000313|Ensembl:ENSP00000477835};
GN   Name=NCAM1 {ECO:0000313|Ensembl:ENSP00000477835};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000477835, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000477835, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [3] {ECO:0000313|Ensembl:ENSP00000477835}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AP000802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP002853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FP884230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF511120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WTF6; -.
DR   EPD; A0A087WTF6; -.
DR   jPOST; A0A087WTF6; -.
DR   PeptideAtlas; A0A087WTF6; -.
DR   Ensembl; ENST00000618266; ENSP00000477835; ENSG00000149294.
DR   UCSC; uc058hjq.1; human.
DR   EuPathDB; HostDB:ENSG00000149294.16; -.
DR   HGNC; HGNC:7656; NCAM1.
DR   OpenTargets; ENSG00000149294; -.
DR   eggNOG; ENOG410IQJI; Eukaryota.
DR   eggNOG; ENOG410XTGB; LUCA.
DR   GeneTree; ENSGT00940000155743; -.
DR   ChiTaRS; NCAM1; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149294; Expressed in 220 organ(s), highest expression level in neocortex.
DR   ExpressionAtlas; A0A087WTF6; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 2.60.40.10; -; 7.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR033019; Ncam1.
DR   InterPro; IPR009138; Neural_cell_adh.
DR   PANTHER; PTHR44059:SF2; PTHR44059:SF2; 2.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF07679; I-set; 3.
DR   PRINTS; PR01838; NCAMFAMILY.
DR   SMART; SM00060; FN3; 2.
DR   SMART; SM00409; IG; 5.
DR   SMART; SM00408; IGc2; 5.
DR   SUPFAM; SSF48726; SSF48726; 5.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   PROSITE; PS50853; FN3; 2.
DR   PROSITE; PS50835; IG_LIKE; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A087WTF6,
KW   ECO:0000213|MaxQB:A0A087WTF6, ECO:0000213|PeptideAtlas:A0A087WTF6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00923712};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    848       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831903.
FT   TRANSMEM    713    736       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       20    111       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      116    189       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      212    301       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      308    403       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      406    491       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      499    598       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      601    696       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
SQ   SEQUENCE   848 AA;  93330 MW;  68D2B5C0E6C172AD CRC64;
     MLQTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK DISWFSPNGE
     KLTPNQQRIS VVWNDDSSST LTIYNANIDD AGIYKCVVTG EDGSESEATV NVKIFQKLMF
     KNAPTPQEFR EGEDAVIVCD VVSSLPPTII WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK
     KTDEGTYRCE GRILARGEIN FKDIQVIVNV PPTIQARQNI VNATANLGQS VTLVCDAEGF
     PEPTMSWTKD GEQIEQEEDD EKYIFSDDSS QLTIKKVDKN DEAEYICIAE NKAGEQDATI
     HLKVFAKPKI TYVENQTAME LEEQVTLTCE ASGDPIPSIT WRTSTRNISS EEKTLDGHMV
     VRSHARVSSL TLKSIQYTDA GEYICTASNT IGQDSQSMYL EVQYAPKLQG PVAVYTWEGN
     QVNITCEVFA YPSATISWFR DGQLLPSSNY SNIKIYNTPS ASYLEVTPDS ENDFGNYNCT
     AVNRIGQESL EFILVQADTP SSPSIDQVEP YSSTAQVQFD EPEATGGVPI LKYKAEWRAV
     GEEVWHSKWY DAKEASMEGI VTIVGLKPET TYAVRLAALN GKGLGEISAA SEFKTQPVPG
     EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVRYR ALSSEWKPEI RLPSGSDHVM
     LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF RTSAQPTAIP ANGSPTSGLS TGAIVGILIV
     IFVLLLVVVD ITCYFLNKCG LFMCIAVNLC GKAGPGAKGK DMEEGKAAFS KDESKEPIVE
     VRTEEERTPN HDGGKHTEPN ETTPLTEPEK GPVEAKPECQ ETETKPAPAE VKTVPNDATQ
     TKENESKA
//