ID   A0A087WTA8_HUMAN        Unreviewed;      1364 AA.
AC   A0A087WTA8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 32.
DE   SubName: Full=Collagen alpha-2(I) chain {ECO:0000313|Ensembl:ENSP00000477719};
GN   Name=COL1A2 {ECO:0000313|Ensembl:ENSP00000477719};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000477719, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000477719, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000213|PubMed:22905912}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22905912; DOI=10.1021/pr300539b;
RA   Rosenow A., Noben J.P., Jocken J., Kallendrusch S.,
RA   Fischer-Posovszky P., Mariman E.C., Renes J.;
RT   "Resveratrol-induced changes of the human adipocyte secretion
RT   profile.";
RL   J. Proteome Res. 11:4733-4743(2012).
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [4] {ECO:0000313|Ensembl:ENSP00000477719}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC002074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC002528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WTA8; -.
DR   EPD; A0A087WTA8; -.
DR   jPOST; A0A087WTA8; -.
DR   PeptideAtlas; A0A087WTA8; -.
DR   Ensembl; ENST00000620463; ENSP00000477719; ENSG00000164692.
DR   UCSC; uc064fkx.1; human.
DR   EuPathDB; HostDB:ENSG00000164692.17; -.
DR   HGNC; HGNC:2198; COL1A2.
DR   OpenTargets; ENSG00000164692; -.
DR   eggNOG; KOG3544; Eukaryota.
DR   eggNOG; ENOG410XNMM; LUCA.
DR   GeneTree; ENSGT00940000155639; -.
DR   ChiTaRS; COL1A2; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000164692; Expressed in 238 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; A0A087WTA8; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR000885; Fib_collagen_C.
DR   Pfam; PF01410; COLFI; 1.
DR   Pfam; PF01391; Collagen; 6.
DR   ProDom; PD002078; Fib_collagen_C; 1.
DR   SMART; SM00038; COLFI; 1.
DR   PROSITE; PS51461; NC1_FIB; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A087WTA8,
KW   ECO:0000213|PeptideAtlas:A0A087WTA8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1364       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831888.
FT   DOMAIN     1131   1364       Fibrillar collagen NC1.
FT                                {ECO:0000259|PROSITE:PS51461}.
SQ   SEQUENCE   1364 AA;  129151 MW;  4DDD14FEE5C6ED82 CRC64;
     MLSFVDTRTL LLLAVTLCLA TCQFFETVRK GPAGDRGPRG ERGPPGPPGR DGEDGPTGPP
     GPPGPPGPPG LGGNFAAQYD GKGVGLGPGP MGLMGPRGPP GAAGAPGPQG FQGPAGEPGE
     PGQTGPAGAR GPAGPPGKAG EDGHPGKPGR PGERGVVGPQ GARGFPGTPG LPGFKGIRGH
     NGLDGLKGQP GAPGVKGEPG APGENGTPGQ TGARGLPGER GRVGAPGPAG ARGSDGSVGP
     VGPAGPIGSA GPPGFPGAPG PKGEIGAVGN AGPAGPAGPR GEVGLPGLSG PVGPPGNPGA
     NGLTGAKGAA GLPGVAGAPG LPGPRGIPGP VGAAGATGAR GLVGEPGPAG SKGESGNKGE
     PGSAGPQGPP GPSGEEGKRG PNGEAGSAGP PGPPGLRGSP GSRGLPGADG RAGVMGPPGS
     RGASGPAGVR GPNGDAGRPG EPGLMGPRGL PGSPGNIGPA GKEGPVGLPG IDGRPGPIGP
     AGARGEPGNI GFPGPKGPTG DPGKNGDKGH AGLAGARGAP GPDGNNGAQG PPGPQGVQGG
     KGEQGPPGPP GFQGLPGPSG PAGEVGKPGE RGLHGEFGLP GPAGPRGERG PPGESGAAGP
     TGPIGSRGPS GPPGPDGNKG EPGVVGAVGT AGPSGPSGLP GERGAAGIPG GKGEKGEPGL
     RGEIGNPGRD GARGAPGAVG APGPAGATGD RGEAGAAGPA GPAGPRGSPG ERGEVGPAGP
     NGFAGPAGAA GQPGAKGERG AKGPKGENGV VGPTGPVGAA GPAGPNGPPG PAGSRGDGGP
     PGMTGFPGAA GRTGPPGPSG ISGPPGPPGP AGKEGLRGPR GDQGPVGRTG EVGAVGPPGF
     AGEKGPSGEA GTAGPPGTPG PQGLLGAPGI LGLPGSRGER GLPGVAGAVG EPGPLGIAGP
     PGARGPPGAV GSPGVNGAPG EAGRDGNPGN DGPPGRDGQP GHKGERGYPG NIGPVGAAGA
     PGPHGPVGPA GKHGNRGETG PSGPVGPAGA VGPRGPSGPQ GIRGDKGEPG EKGPRGLPGL
     KGHNGLQGLP GIAGHHGDQG APGSVGPAGP RGPAGPSGPA GKDGRTGHPG TVGPAGIRGP
     QGHQGPAGPP GPPGPPGPPG VSGGGYDFGY DGDFYRADQP RSAPSLRPKD YEVDATLKSL
     NNQIETLLTP EGSRKNPART CRDLRLSHPE WSSGYYWIDP NQGCTMDAIK VYCDFSTGET
     CIRAQPENIP AKNWYRSSKD KKHVWLGETI NAGSQFEYNV EGVTSKEMAT QLAFMRLLAN
     YASQNITYHC KNSIAYMDEE TGNLKKAVIL QGSNDVELVA EGNSRFTYTV LVDGCSKKTN
     EWGKTIIEYK TNKPSRLPFL DIAPLDIGGA DQEFFVDIGP VCFK
//