ID   A0A087WT59_HUMAN        Unreviewed;       185 AA.
AC   A0A087WT59;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 28.
DE   RecName: Full=Transthyretin {ECO:0000256|RuleBase:RU361269};
GN   Name=TTR {ECO:0000313|Ensembl:ENSP00000477599};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000477599, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000477599, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA   Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA   Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA   Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA   Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA   Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA   O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA   Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA   Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [3] {ECO:0000313|Ensembl:ENSP00000477599}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- FUNCTION: Thyroid hormone-binding protein. Probably transports
CC       thyroxine from the bloodstream to the brain.
CC       {ECO:0000256|RuleBase:RU361269}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU361269}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361269}.
CC   -!- SIMILARITY: Belongs to the transthyretin family.
CC       {ECO:0000256|RuleBase:RU361269}.
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DR   EMBL; AC079096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WT59; -.
DR   SMR; A0A087WT59; -.
DR   jPOST; A0A087WT59; -.
DR   PeptideAtlas; A0A087WT59; -.
DR   Ensembl; ENST00000610404; ENSP00000477599; ENSG00000118271.
DR   UCSC; uc060ofw.1; human.
DR   EuPathDB; HostDB:ENSG00000118271.9; -.
DR   HGNC; HGNC:12405; TTR.
DR   OpenTargets; ENSG00000118271; -.
DR   GeneTree; ENSGT00940000153229; -.
DR   OMA; HRHYTIA; -.
DR   ChiTaRS; TTR; human.
DR   Proteomes; UP000005640; Chromosome 18.
DR   Bgee; ENSG00000118271; Expressed in 125 organ(s), highest expression level in pigmented layer of retina.
DR   ExpressionAtlas; A0A087WT59; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0070324; F:thyroid hormone binding; IEA:InterPro.
DR   GO; GO:0042572; P:retinol metabolic process; IEA:InterPro.
DR   GO; GO:0070327; P:thyroid hormone transport; IEA:InterPro.
DR   Gene3D; 2.60.40.180; -; 2.
DR   InterPro; IPR023418; Thyroxine_BS.
DR   InterPro; IPR030178; Transthyretin.
DR   InterPro; IPR000895; Transthyretin/HIU_hydrolase.
DR   InterPro; IPR023416; Transthyretin/HIU_hydrolase_d.
DR   InterPro; IPR036817; Transthyretin/HIU_hydrolase_sf.
DR   InterPro; IPR023419; Transthyretin_CS.
DR   PANTHER; PTHR10395; PTHR10395; 2.
DR   PANTHER; PTHR10395:SF12; PTHR10395:SF12; 2.
DR   Pfam; PF00576; Transthyretin; 1.
DR   PRINTS; PR00189; TRNSTHYRETIN.
DR   SMART; SM00095; TR_THY; 1.
DR   SUPFAM; SSF49472; SSF49472; 2.
DR   PROSITE; PS00768; TRANSTHYRETIN_1; 1.
DR   PROSITE; PS00769; TRANSTHYRETIN_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hormone {ECO:0000256|RuleBase:RU361269};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A087WT59,
KW   ECO:0000213|PeptideAtlas:A0A087WT59};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|RuleBase:RU361269};
KW   Signal {ECO:0000256|RuleBase:RU361269};
KW   Thyroid hormone {ECO:0000256|RuleBase:RU361269}.
FT   SIGNAL        1     20       {ECO:0000256|RuleBase:RU361269}.
FT   CHAIN        21    185       Transthyretin.
FT                                {ECO:0000256|RuleBase:RU361269}.
FT                                /FTId=PRO_5005106655.
FT   DOMAIN       27    185       TR_THY. {ECO:0000259|SMART:SM00095}.
SQ   SEQUENCE   185 AA;  20146 MW;  2360F56E71D7814B CRC64;
     MASHRLLLLC LAGLVFVSEA GPTGTGESKC PLMVKVLDAV RGSPAINVAV HVFRKAADDT
     WEPFASGKTS ESGELHGLTT EEEFVEGIYK VEIDTKSYWK ALGISPFHEH AEVSIQTFES
     FETDGCHGNR IQTCSSWSEL QTSGFHQNVD VVFTANDSGP RRYTIAALLS PYSYSTTAVV
     TNPKE
//