ID   A0A087WSY5_HUMAN        Unreviewed;       386 AA.
AC   A0A087WSY5;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 32.
DE   SubName: Full=Carboxypeptidase B2 {ECO:0000313|Ensembl:ENSP00000400714};
GN   Name=CPB2 {ECO:0000313|Ensembl:ENSP00000400714};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000400714, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000400714, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA   Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA   Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA   Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA   Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA   Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA   Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA   Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA   Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA   Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA   Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA   Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA   King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA   Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA   Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA   Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA   Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA   Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.,
RA   Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000400714}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AL137141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL157758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001265470.1; NM_001278541.1.
DR   UniGene; Hs.512937; -.
DR   ProteinModelPortal; A0A087WSY5; -.
DR   jPOST; A0A087WSY5; -.
DR   PeptideAtlas; A0A087WSY5; -.
DR   PRIDE; A0A087WSY5; -.
DR   Ensembl; ENST00000439329; ENSP00000400714; ENSG00000080618.
DR   GeneID; 1361; -.
DR   UCSC; uc031qlk.1; human.
DR   CTD; 1361; -.
DR   EuPathDB; HostDB:ENSG00000080618.13; -.
DR   HGNC; HGNC:2300; CPB2.
DR   OpenTargets; ENSG00000080618; -.
DR   GeneTree; ENSGT00940000159160; -.
DR   OrthoDB; 524270at2759; -.
DR   ChiTaRS; CPB2; human.
DR   GenomeRNAi; 1361; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   Bgee; ENSG00000080618; Expressed in 67 organ(s), highest expression level in liver.
DR   ExpressionAtlas; A0A087WSY5; baseline and differential.
DR   GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.70.340; -; 1.
DR   InterPro; IPR036990; M14A-like_propep.
DR   InterPro; IPR003146; M14A_act_pep.
DR   InterPro; IPR000834; Peptidase_M14.
DR   Pfam; PF00246; Peptidase_M14; 2.
DR   Pfam; PF02244; Propep_M14; 1.
DR   PRINTS; PR00765; CRBOXYPTASEA.
DR   SMART; SM00631; Zn_pept; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A087WSY5,
KW   ECO:0000213|PeptideAtlas:A0A087WSY5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    386       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831887.
FT   DOMAIN      123    370       Peptidase_M14.
FT                                {ECO:0000259|SMART:SM00631}.
SQ   SEQUENCE   386 AA;  44022 MW;  76EAAED94C8E8F40 CRC64;
     MKLCSLAVLV PIVLFCEQHV FAFQSGQVLA ALPRTSRQVQ VLQNLTTTYE IVLWQPVTAD
     LIVKKKQVHF FVNASDVDNV KAHLNVSGIP CSVLLADVED LIQQQISNDT VSPRASASYY
     EQYHSLNEIY SWIEFITERH PDMLTKIHIG SSFEKYPLYV LKVSGKEQAA KNAIWIDCGI
     HAREWISPAF CLWFIGHNRM WRKNRSFYAN NHCIGTDLNR NFASKHWCEE GASSSSCSET
     YCGLYPESEP EVKAVASFLR RNINQIKAYI SMHSYSQHIV FPYSYTRSKS KDHEELSLVA
     SEAVRAIEKI SKNTRYTHGH GSETLYLAPG GGDDWIYDLG IKYSFTIELR DTGTYGFLLP
     ERYIKPTCRE AFAAVSKIAW HVIRNV
//