ID   A0A087WSW8_HUMAN        Unreviewed;       776 AA.
AC   A0A087WSW8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   05-DEC-2018, entry version 37.
DE   SubName: Full=Protocadherin alpha-4 {ECO:0000313|Ensembl:ENSP00000367365};
GN   Name=PCDHA4 {ECO:0000313|Ensembl:ENSP00000367365};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000367365, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000367365, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000367365}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC005609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC008468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087WSW8; -.
DR   EPD; A0A087WSW8; -.
DR   PeptideAtlas; A0A087WSW8; -.
DR   Ensembl; ENST00000378125; ENSP00000367365; ENSG00000204967.
DR   UCSC; uc063hyl.1; human.
DR   EuPathDB; HostDB:ENSG00000204967.10; -.
DR   HGNC; HGNC:8670; PCDHA4.
DR   OpenTargets; ENSG00000204967; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   eggNOG; ENOG410XQHI; LUCA.
DR   GeneTree; ENSGT00940000163846; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000204967; Expressed in 64 organ(s), highest expression level in body of pancreas.
DR   ExpressionAtlas; A0A087WSW8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; SSF49313; 6.
DR   PROSITE; PS00232; CADHERIN_1; 3.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Cell adhesion {ECO:0000256|SAAS:SAAS00049551};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087WSW8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29    776       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001831872.
FT   TRANSMEM    697    717       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       44    130       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      154    239       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      263    347       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      371    452       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      476    562       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      593    675       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   776 AA;  83615 MW;  95D6C4C368969980 CRC64;
     VVYSRVGQES RRLLLLLLLL AAWEAGNGQL HYSVSEEAKH GTFVGRIAQD LGLELAELVP
     RLFRVASKGR GGLLEVNLQN GILFVNSRID REELCRRSAE CSIHLEVIVD RPLQVFHVDV
     EVRDINDNPP VFPATQKNLS IAESRPLDSR FPLEGASDAD IGENALLTYR LSPNEYFSLE
     KPPDDELVKG LGLILRKSLD REEAPEIFLV LTATDGGKPE LTGTVQLLIT VLDANDNAPA
     FDRTIYKVRL LENVPNGTLV IKLNASDLDE GLNGDIVYSF SNDISPNVKS KFHIDPITGQ
     IIVKGYIDFE ESKSYEIIVE GIDKGQLPLS GHCRVIVEVE DNNDNVPDLE FKSLSLPIRE
     DAPLGTVIAL ISVSDKDMGV NGLVTCSLTS HVPFKLVSTF KNYYSLVLDS ALDRESVSAY
     ELVVTARDGG SPSLWATASV SVEVADVNDN APAFAQPEYT VFVKENNPPG CHIFTVSAWD
     ADAQENALVS YSLVERRVGE RALSSYVSVH AESGKVYALQ PLDHEELELL QFQVTARDAG
     VPPLGSNVTL QVFVLDENDN APALLAPRAG GTGGAVSELV PWSVGVGHVV AKVRAVDADS
     GYNAWLSYEL QPGTGGARIP FRVGLYTGEI STTRALDETD APRHRLLVLV KDHGEPALTA
     TATVLVSLVE SGQAPKASSR ALVGAVGPDA ALVDVNVYLI IAICAVSSLL VLTLLLYTAL
     RCSALPTEGA CAPGKPTLVC SSAVGSWSYS QQRRPRVCSG EGPPKTDLMA FSPSLP
//