ID   A0A075B7C5_HUMAN        Unreviewed;       150 AA.
AC   A0A075B7C5;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 29.
DE   SubName: Full=C-C motif chemokine 5 {ECO:0000313|Ensembl:ENSP00000474141};
DE   Flags: Fragment;
GN   Name=CCL5 {ECO:0000313|Ensembl:ENSP00000474141};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000474141, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000474141, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000474141}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2014) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000488072}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2015) to UniProtKB.
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DR   EMBL; AC015849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; A0A075B7C5; -.
DR   PeptideAtlas; A0A075B7C5; -.
DR   Ensembl; ENST00000605509; ENSP00000474141; ENSG00000271503.
DR   Ensembl; ENST00000632752; ENSP00000488072; ENSG00000274233.
DR   UCSC; uc060eei.1; human.
DR   EuPathDB; HostDB:ENSG00000271503.5; -.
DR   HGNC; HGNC:10632; CCL5.
DR   OpenTargets; ENSG00000271503; -.
DR   GeneTree; ENSGT00940000153888; -.
DR   ChiTaRS; CCL5; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000271503; Expressed in 187 organ(s), highest expression level in blood.
DR   ExpressionAtlas; A0A075B7C5; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0031726; F:CCR1 chemokine receptor binding; IEA:InterPro.
DR   GO; GO:0031729; F:CCR4 chemokine receptor binding; IEA:InterPro.
DR   GO; GO:0031730; F:CCR5 chemokine receptor binding; IEA:InterPro.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0009615; P:response to virus; IEA:InterPro.
DR   InterPro; IPR030595; CCL5.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   PANTHER; PTHR12015:SF82; PTHR12015:SF82; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A075B7C5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    150       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014011171.
FT   DOMAIN       26     76       SCY. {ECO:0000259|SMART:SM00199}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000474141}.
SQ   SEQUENCE   150 AA;  16632 MW;  633995ACEFCDA2A9 CRC64;
     XAALAVILIA TALCAPASAS PYSSDTTPCC FAYIARPLPR AHIKEYFYTS GKCSNPAVVH
     RSRMPKREGQ QVWQDFLYDS RLNKGKLCHP KEPPSVCQPR EEMGSGVHQL FGDELGWRVL
     EPELTQICLF LLALVLAWEA SPHYPTPPAP
//